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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTROS309801:G1GU8-2594-MONOMER
UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:trd_A0802
Encoded oniPlasmid Tros0 Publication
OrganismiThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Taxonomic identifieri309801 [NCBI]
Taxonomic lineageiBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium
Proteomesi
  • UP000000447 Componenti: Plasmid Tros

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003987201 – 2002-phospho-L-lactate guanylyltransferaseAdd BLAST200

Structurei

3D structure databases

SMRiB9L4T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223639
KOiK14941
OMAiAMLVDTI
OrthoDBiPOG091H0B3J

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

B9L4T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVLAVVPVQ RLEQAKSRLA PALEPAARQA LVRELAERTI RILRSVPAVA
60 70 80 90 100
VIGLLTPDPS LASLASRWGV RTLRDAAHGL NDAVRLAQAE ACRLHLPALL
110 120 130 140 150
IVLGDLPLLD PHAIRHALAL LESPGVVLAP DRHGTGTNLL ALAPPDVIAP
160 170 180 190 200
AFGPFSRWRH RRAAAGARCT IRELWSRALV LDLDTPEDLA LVHRVREGER
Length:200
Mass (Da):21,668
Last modified:March 24, 2009 - v1
Checksum:i87ACD2DADA5E3637
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001276 Genomic DNA Translation: ACM06659.1
RefSeqiWP_012642646.1, NC_011961.1

Genome annotation databases

EnsemblBacteriaiACM06659; ACM06659; trd_A0802
KEGGitro:trd_A0802

Entry informationi

Entry nameiCOFC_THERP
AccessioniPrimary (citable) accession number: B9L4T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 24, 2009
Last modified: February 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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