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B9L2J1

- ACDH_THERP

UniProt

B9L2J1 - ACDH_THERP

Protein

Acetaldehyde dehydrogenase

Gene

trd_1393

Organism
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 2 (03 Nov 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Acyl-thioester intermediateUniRule annotation
    Binding sitei280 – 2801NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 174NADUniRule annotation
    Nucleotide bindingi160 – 1689NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciTROS309801:GI0S-1381-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Ordered Locus Names:trd_1393
    OrganismiThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
    Taxonomic identifieri309801 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium
    ProteomesiUP000000447: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Acetaldehyde dehydrogenasePRO_0000387748Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi309801.trd_1393.

    Structurei

    3D structure databases

    ProteinModelPortaliB9L2J1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9L2J1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGERQAVKVA ILGTGNIGTD LMYKLLRNPG HMELAMFAGI DPQSEGIARA    50
    KKLGIPTSYE GIKAVLDDPE IRIVFDATSA KAHVRHAKML REAGKIAIDL 100
    TPAARGPYVV PPVNLGAHLD KDNVNLITCG GQATIPLVFA VSRVVPVRYA 150
    EIVSTVASKS AGPGTRQNID EFTFTTAHGL EAIGGAEQGK AIIILNPAEP 200
    PIIMRNTVYV IPANEEFDQA AIVASVDQMV AEVQQYVPGY RLKDAPVFDR 250
    RRTPWGERTI IAMLLEVEGA GDFLPPYSGN LDIMTAAAWR VGELFAQHLL 300
    GIRQEVAA 308
    Length:308
    Mass (Da):33,155
    Last modified:November 3, 2009 - v2
    Checksum:i640FEDC11586B542
    GO

    Sequence cautioni

    The sequence ACM04754.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001275 Genomic DNA. Translation: ACM04754.1. Different initiation.
    RefSeqiYP_002522598.1. NC_011959.1.

    Genome annotation databases

    EnsemblBacteriaiACM04754; ACM04754; trd_1393.
    GeneIDi7354783.
    KEGGitro:trd_1393.
    PATRICi23913958. VBITheRos91376_1325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001275 Genomic DNA. Translation: ACM04754.1 . Different initiation.
    RefSeqi YP_002522598.1. NC_011959.1.

    3D structure databases

    ProteinModelPortali B9L2J1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309801.trd_1393.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM04754 ; ACM04754 ; trd_1393 .
    GeneIDi 7354783.
    KEGGi tro:trd_1393.
    PATRICi 23913958. VBITheRos91376_1325.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci TROS309801:GI0S-1381-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum."
      Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A.
      PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27502 / DSM 5159 / P-2.

    Entry informationi

    Entry nameiACDH_THERP
    AccessioniPrimary (citable) accession number: B9L2J1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 3, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3