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Protein

Acetaldehyde dehydrogenase

Gene

trd_1393

Organism
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129Acyl-thioester intermediateUniRule annotation1
Binding sitei280NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 17NADUniRule annotation4
Nucleotide bindingi160 – 168NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Enzyme and pathway databases

BioCyciTROS309801:G1GU8-1310-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:trd_1393
OrganismiThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Taxonomic identifieri309801 [NCBI]
Taxonomic lineageiBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium
Proteomesi
  • UP000000447 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003877481 – 308Acetaldehyde dehydrogenaseAdd BLAST308

Proteomic databases

PRIDEiB9L2J1

Interactioni

Protein-protein interaction databases

STRINGi309801.trd_1393

Structurei

3D structure databases

ProteinModelPortaliB9L2J1
SMRiB9L2J1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DIV Bacteria
COG4569 LUCA
HOGENOMiHOG000052149
KOiK04073
OrthoDBiPOG091H09NP

Family and domain databases

HAMAPiMF_01657 Ac_ald_DH_ac, 1 hit
InterProiView protein in InterPro
IPR003361 Acetaldehyde_dehydrogenase
IPR015426 Acetylaldehyde_DH_C
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
PfamiView protein in Pfam
PF09290 AcetDehyd-dimer, 1 hit
PF01118 Semialdhyde_dh, 1 hit
PIRSFiPIRSF015689 Actaldh_dh_actl, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03215 ac_ald_DH_ac, 1 hit

Sequencei

Sequence statusi: Complete.

B9L2J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGERQAVKVA ILGTGNIGTD LMYKLLRNPG HMELAMFAGI DPQSEGIARA
60 70 80 90 100
KKLGIPTSYE GIKAVLDDPE IRIVFDATSA KAHVRHAKML REAGKIAIDL
110 120 130 140 150
TPAARGPYVV PPVNLGAHLD KDNVNLITCG GQATIPLVFA VSRVVPVRYA
160 170 180 190 200
EIVSTVASKS AGPGTRQNID EFTFTTAHGL EAIGGAEQGK AIIILNPAEP
210 220 230 240 250
PIIMRNTVYV IPANEEFDQA AIVASVDQMV AEVQQYVPGY RLKDAPVFDR
260 270 280 290 300
RRTPWGERTI IAMLLEVEGA GDFLPPYSGN LDIMTAAAWR VGELFAQHLL

GIRQEVAA
Length:308
Mass (Da):33,155
Last modified:November 3, 2009 - v2
Checksum:i640FEDC11586B542
GO

Sequence cautioni

The sequence ACM04754 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001275 Genomic DNA Translation: ACM04754.1 Different initiation.
RefSeqiWP_041436016.1, NC_011959.1

Genome annotation databases

EnsemblBacteriaiACM04754; ACM04754; trd_1393
KEGGitro:trd_1393

Similar proteinsi

Entry informationi

Entry nameiACDH_THERP
AccessioniPrimary (citable) accession number: B9L2J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: May 23, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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