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B9L2J1 (ACDH_THERP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase

EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Ordered Locus Names:trd_1393
OrganismThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) [Complete proteome] [HAMAP]
Taxonomic identifier309801 [NCBI]
Taxonomic lineageBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP-Rule MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP-Rule MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Sequence caution

The sequence ACM04754.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionNAD binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Acetaldehyde dehydrogenase HAMAP-Rule MF_01657
PRO_0000387748

Regions

Nucleotide binding14 – 174NAD By similarity
Nucleotide binding160 – 1689NAD By similarity

Sites

Active site1291Acyl-thioester intermediate By similarity
Binding site2801NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B9L2J1 [UniParc].

Last modified November 3, 2009. Version 2.
Checksum: 640FEDC11586B542

FASTA30833,155
        10         20         30         40         50         60 
MGERQAVKVA ILGTGNIGTD LMYKLLRNPG HMELAMFAGI DPQSEGIARA KKLGIPTSYE 

        70         80         90        100        110        120 
GIKAVLDDPE IRIVFDATSA KAHVRHAKML REAGKIAIDL TPAARGPYVV PPVNLGAHLD 

       130        140        150        160        170        180 
KDNVNLITCG GQATIPLVFA VSRVVPVRYA EIVSTVASKS AGPGTRQNID EFTFTTAHGL 

       190        200        210        220        230        240 
EAIGGAEQGK AIIILNPAEP PIIMRNTVYV IPANEEFDQA AIVASVDQMV AEVQQYVPGY 

       250        260        270        280        290        300 
RLKDAPVFDR RRTPWGERTI IAMLLEVEGA GDFLPPYSGN LDIMTAAAWR VGELFAQHLL 


GIRQEVAA 

« Hide

References

[1]"Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum."
Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A.
PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27502 / DSM 5159 / P-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001275 Genomic DNA. Translation: ACM04754.1. Different initiation.
RefSeqYP_002522598.1. NC_011959.1.

3D structure databases

ProteinModelPortalB9L2J1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309801.trd_1393.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM04754; ACM04754; trd_1393.
GeneID7354783.
KEGGtro:trd_1393.
PATRIC23913958. VBITheRos91376_1325.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHOG000052149.
KOK04073.
OrthoDBEOG6H1PXH.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycTROS309801:GI0S-1381-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_01657. Ac_ald_DH_ac.
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_THERP
AccessionPrimary (citable) accession number: B9L2J1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 3, 2009
Last modified: February 19, 2014
This is version 38 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families