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B9L1A9 (PYRF_THERP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:trd_0010
OrganismThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) [Complete proteome] [HAMAP]
Taxonomic identifier309801 [NCBI]
Taxonomic lineageBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium

Protein attributes

Sequence length281 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 281281Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_1000164751

Sites

Active site941Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
B9L1A9 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 43AF2CCF5D00E5F5

FASTA28130,141
        10         20         30         40         50         60 
MSFRERLEQT IAQNHSLLCI GLDPDLERFP TGIPRDPEGI VVFNRAIIEA TADLVCAYKP 

        70         80         90        100        110        120 
NLAFYLQYGA AGIAALATTR QLIPPHIPVI LDAKLGDIAS TSAAYARAVF ETLGFDALTV 

       130        140        150        160        170        180 
HPYLGSEALE PFLSTSDRGV FVLVRTSNPG ASEIQDLPVG EAGEPLYLWL AERARAWNQR 

       190        200        210        220        230        240 
SGNVGLVVGA TYPVDLALVR QRCPDLPILA PGIGAQGGDL ERAVCAGLTE ATAPLLVTVS 

       250        260        270        280 
RSILYADASA RFAESARAAA RRVRDTIERI RKEVAGQAGH R 

« Hide

References

[1]"Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum."
Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A.
PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27502 / DSM 5159 / P-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001275 Genomic DNA. Translation: ACM05119.1.
RefSeqYP_002521267.1. NC_011959.1.

3D structure databases

ProteinModelPortalB9L1A9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309801.trd_0010.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM05119; ACM05119; trd_0010.
GeneID7355184.
KEGGtro:trd_0010.
PATRIC23911236. VBITheRos91376_0008.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245747.
KOK01591.
OMADATHHLC.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycTROS309801:GI0S-9-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRF_THERP
AccessionPrimary (citable) accession number: B9L1A9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways