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B9L1A9

- PYRF_THERP

UniProt

B9L1A9 - PYRF_THERP

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, trd_0010
Organism
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei94 – 941Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciTROS309801:GI0S-9-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:trd_0010
OrganismiThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Taxonomic identifieri309801 [NCBI]
Taxonomic lineageiBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium
ProteomesiUP000000447: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000164751Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi309801.trd_0010.

Structurei

3D structure databases

ProteinModelPortaliB9L1A9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiDATHHLC.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

B9L1A9-1 [UniParc]FASTAAdd to Basket

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MSFRERLEQT IAQNHSLLCI GLDPDLERFP TGIPRDPEGI VVFNRAIIEA    50
TADLVCAYKP NLAFYLQYGA AGIAALATTR QLIPPHIPVI LDAKLGDIAS 100
TSAAYARAVF ETLGFDALTV HPYLGSEALE PFLSTSDRGV FVLVRTSNPG 150
ASEIQDLPVG EAGEPLYLWL AERARAWNQR SGNVGLVVGA TYPVDLALVR 200
QRCPDLPILA PGIGAQGGDL ERAVCAGLTE ATAPLLVTVS RSILYADASA 250
RFAESARAAA RRVRDTIERI RKEVAGQAGH R 281
Length:281
Mass (Da):30,141
Last modified:March 24, 2009 - v1
Checksum:i43AF2CCF5D00E5F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001275 Genomic DNA. Translation: ACM05119.1.
RefSeqiYP_002521267.1. NC_011959.1.

Genome annotation databases

EnsemblBacteriaiACM05119; ACM05119; trd_0010.
GeneIDi7355184.
KEGGitro:trd_0010.
PATRICi23911236. VBITheRos91376_0008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001275 Genomic DNA. Translation: ACM05119.1 .
RefSeqi YP_002521267.1. NC_011959.1.

3D structure databases

ProteinModelPortali B9L1A9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309801.trd_0010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM05119 ; ACM05119 ; trd_0010 .
GeneIDi 7355184.
KEGGi tro:trd_0010.
PATRICi 23911236. VBITheRos91376_0008.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi DATHHLC.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci TROS309801:GI0S-9-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum."
    Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A.
    PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27502 / DSM 5159 / P-2.

Entry informationi

Entry nameiPYRF_THERP
AccessioniPrimary (citable) accession number: B9L1A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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