B9L0C1DEF_THERPPeptide deformylasePDF3.5.1.88Polypeptide deformylasedeftrd_1614Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)BacteriaThermomicrobiotaThermomicrobiaThermomicrobialesThermomicrobiaceaeThermomicrobiumComplete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]Fe(2+)Binds 1 Fe(2+) ion.Belongs to the polypeptide deformylase family.HydrolaseIronMetal-bindingProtein biosynthesisFe cationFe cationFe cationMAVRTIITEGDPRLRQKAIRIRVVDEEVRQLARDLWDTVRAARGLGLAAPQIGVLRRIIVVAIPPDYVEEGDPGVELTLINPEIVRASGRQVGLEGCLSIPGWYGEVPRSMHVTVKALDLDGREVRVKGSGLLARVLQHEIDHLEGILFVDRIEDRSTLRYIPDEEEETAEAATGT
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