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B9L0C1

- DEF_THERP

UniProt

B9L0C1 - DEF_THERP

Protein

Peptide deformylase

Gene

def

Organism
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi97 – 971IronUniRule annotation
    Metal bindingi139 – 1391IronUniRule annotation
    Active sitei140 – 1401UniRule annotation
    Metal bindingi143 – 1431IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciTROS309801:GI0S-1600-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:trd_1614
    OrganismiThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
    Taxonomic identifieri309801 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium
    ProteomesiUP000000447: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 176176Peptide deformylasePRO_1000200753Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi309801.trd_1614.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243508.
    KOiK01462.
    OMAiMEMVFYP.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9L0C1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVRTIITEG DPRLRQKAIR IRVVDEEVRQ LARDLWDTVR AARGLGLAAP    50
    QIGVLRRIIV VAIPPDYVEE GDPGVELTLI NPEIVRASGR QVGLEGCLSI 100
    PGWYGEVPRS MHVTVKALDL DGREVRVKGS GLLARVLQHE IDHLEGILFV 150
    DRIEDRSTLR YIPDEEEETA EAATGT 176
    Length:176
    Mass (Da):19,517
    Last modified:March 24, 2009 - v1
    Checksum:i8CCE7ABADCD44A49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001275 Genomic DNA. Translation: ACM05222.1.
    RefSeqiWP_015922559.1. NC_011959.1.
    YP_002522816.1. NC_011959.1.

    Genome annotation databases

    EnsemblBacteriaiACM05222; ACM05222; trd_1614.
    GeneIDi7356195.
    KEGGitro:trd_1614.
    PATRICi23914392. VBITheRos91376_1540.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001275 Genomic DNA. Translation: ACM05222.1 .
    RefSeqi WP_015922559.1. NC_011959.1.
    YP_002522816.1. NC_011959.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309801.trd_1614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM05222 ; ACM05222 ; trd_1614 .
    GeneIDi 7356195.
    KEGGi tro:trd_1614.
    PATRICi 23914392. VBITheRos91376_1540.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243508.
    KOi K01462.
    OMAi MEMVFYP.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci TROS309801:GI0S-1600-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum."
      Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A.
      PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27502 / DSM 5159 / P-2.

    Entry informationi

    Entry nameiDEF_THERP
    AccessioniPrimary (citable) accession number: B9L0C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3