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B9KZS7

- MDH_THERP

UniProt

B9KZS7 - MDH_THERP

Protein

Malate dehydrogenase

Gene

mdh

Organism
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331NADUniRule annotation
    Binding sitei82 – 821SubstrateUniRule annotation
    Binding sitei88 – 881SubstrateUniRule annotation
    Binding sitei95 – 951NADUniRule annotation
    Binding sitei120 – 1201SubstrateUniRule annotation
    Binding sitei151 – 1511SubstrateUniRule annotation
    Active sitei175 – 1751Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 146NADUniRule annotation
    Nucleotide bindingi118 – 1203NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciTROS309801:GI0S-913-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:trd_0921
    OrganismiThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
    Taxonomic identifieri309801 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium
    ProteomesiUP000000447: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Malate dehydrogenasePRO_1000206447Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi309801.trd_0921.

    Structurei

    3D structure databases

    ProteinModelPortaliB9KZS7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiLDLMEAQ.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9KZS7-1 [UniParc]FASTAAdd to Basket

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    MRRKVSIIGA GAVGATTAQY LAARNIADLV LVDIVENLPQ GKALDLLEAG    50
    PVLGYDCQIV GSNSYDATAG SDVIVITSGS PRKPGMSRDD LLRVNMNIVR 100
    SVTEQAAPLS PDAVIIVVTN PLDAMCHVAL EASGFPPARV VGQAGVLDAA 150
    RFRAFVALEL GVSPRDVHAM VLGGHGDTMV PLPRYTTVSG IPITQLIPAD 200
    RIQAIVERTR DGGGEIVRLL GTSAFYAPAA SVAEMVEAVL LDANRVLAAS 250
    TYLTGQYGIH DLYVGVPIRL GAGGVKEIIE VELTDEERAA LHRSANAVRE 300
    LVQAMKQLT 309
    Length:309
    Mass (Da):32,492
    Last modified:March 24, 2009 - v1
    Checksum:i0A78AEFCF128D9C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001275 Genomic DNA. Translation: ACM05183.1.
    RefSeqiWP_012642298.1. NC_011959.1.
    YP_002522141.1. NC_011959.1.

    Genome annotation databases

    EnsemblBacteriaiACM05183; ACM05183; trd_0921.
    GeneIDi7355233.
    KEGGitro:trd_0921.
    PATRICi23913020. VBITheRos91376_0871.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001275 Genomic DNA. Translation: ACM05183.1 .
    RefSeqi WP_012642298.1. NC_011959.1.
    YP_002522141.1. NC_011959.1.

    3D structure databases

    ProteinModelPortali B9KZS7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309801.trd_0921.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM05183 ; ACM05183 ; trd_0921 .
    GeneIDi 7355233.
    KEGGi tro:trd_0921.
    PATRICi 23913020. VBITheRos91376_0871.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi LDLMEAQ.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci TROS309801:GI0S-913-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum."
      Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A.
      PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27502 / DSM 5159 / P-2.

    Entry informationi

    Entry nameiMDH_THERP
    AccessioniPrimary (citable) accession number: B9KZS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3