B9KZH9 (B9KZH9_THERP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543 EMBL ACM04799.1
Ordered Locus Names:	trd_0900

Organism

Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) [Complete proteome] [HAMAP]

Taxonomic identifier

309801 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Thermomicrobiales › Thermomicrobiaceae › Thermomicrobium

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS000559
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS000559
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS000559
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS000559 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS000559 EMBL ACM04799.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	60 – 67	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B9KZH9 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 85ACE16E8AC62DED	FASTA	551	58,681
	10 20 30 40 50 60 MSGTQLIKLR PISEIANELG LLPEEVEHYG PYKAKITLDV LARLDTPRAR YILVTGINPT 70 80 90 100 110 120 PFGEGKTTVS VGLGQAFGRL GLRSIVTVRQ SSMGPVFGTK GAGAGGGAAQ LHPFPDLALH 130 140 150 160 170 180 FTGDLHAVTT AHNLLAALID NALYHDTLPL DPRTITWPRV IDLNDRALRQ LIVGLGETTR 190 200 210 220 230 240 TVRATRFDIT PASEVMAILA LARDYRDLRQ RLGQIVVGRT WQGQVVTAED LGGAGAMAAL 250 260 270 280 290 300 LVDALKPNLV QTSEGTAAFV HTGPFGNIAT GASSVVADLV AVRLADVVVT EAGFGTDLGA 310 320 330 340 350 360 EKFFHLKCRA SGLAPHAAVL VASVRALKVQ GGKSVRDIET GGEDLAALEA GLPNLFKHLE 370 380 390 400 410 420 NLRTFGVPAV VAINQFPTDT PREIERLAQA AREAGACDVA VVEVFTCGGE GGLELARAVL 430 440 450 460 470 480 RAAQEPPAFR PVYELDWPLE RKVEAVARTL YGAGAVRFSP AAKRQLDDLV RLGYDRLPIC 490 500 510 520 530 540 MAKTAQSLSA DPNLLGRPED FTVEVRELRL FAGAGYIVVL LGDIQTMPGL GRHPRAAHID 550 IDEHGRILGV S

References

[1]

"Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum." Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A. PLoS ONE 4:E4207-E4207(2009) [PubMed: 19148287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001275 Genomic DNA. Translation: ACM04799.1.
RefSeq	YP_002522121.1. NC_011959.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B9KZH9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7355064.
GenomeReviews	Gene locus trd_0900 in contig CP001275_GR.
KEGG	tro:trd_0900.
PATRIC	23912978. VBITheRos91376_0851.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EIMAVLC.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B9KZH9_THERP

Accession

Primary (citable) accession number: B9KZH9

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	December 14, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)