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B9KZ66 (PGK_THERP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:trd_0779
OrganismThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) [Complete proteome] [HAMAP]
Taxonomic identifier309801 [NCBI]
Taxonomic lineageBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000192857

Regions

Nucleotide binding347 – 3504ATP By similarity
Region19 – 213Substrate binding By similarity
Region57 – 604Substrate binding By similarity

Sites

Binding site341Substrate By similarity
Binding site1161Substrate By similarity
Binding site1491Substrate By similarity
Binding site1991ATP By similarity
Binding site3211ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B9KZ66 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 2B57CDC42C4DE225

FASTA39242,158
        10         20         30         40         50         60 
MRTVRDLEVE ERRVLVRVDY NVPLEGGRVV DDTRIRATLP TLQWLLERRA RIILCSHLGR 

        70         80         90        100        110        120 
PKGQVREELR LAPVAATLSG LLGQPVRSVR DIVGPEAQEM ARRLQPGEVG MLENLRFDPR 

       130        140        150        160        170        180 
EEQNDAEFAA ALAALADCYV NDAFGAAHRA HASVVAVARL LPSAAGFLME REVQALERVL 

       190        200        210        220        230        240 
RSDERPFVLV LGGAKVSDKI GVIENLLPRA DALLLGGGMA NTFLRARGLE TGRSLVEEEK 

       250        260        270        280        290        300 
VPEAQRILDL AAARGVRVEL PRDVVVAPTM SAVSQRRIVP VTAIPPDQAV YDIGPETVRA 

       310        320        330        340        350        360 
YSAVIAGARL LVWNGPMGVY EVPEFREGTK GIAEAVAGCS GFTLVGGGDS AAALQELGLA 

       370        380        390 
ERVGHLSTGG GATLEYLEGR ELPGVAVLME EA 

« Hide

References

[1]"Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum."
Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A.
PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27502 / DSM 5159 / P-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001275 Genomic DNA. Translation: ACM06324.1.
RefSeqYP_002522008.1. NC_011959.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309801.trd_0779.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM06324; ACM06324; trd_0779.
GeneID7354701.
KEGGtro:trd_0779.
PATRIC23912748. VBITheRos91376_0743.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227108.
KOK00927.
OMADMIFDIG.
OrthoDBEOG64N9Z0.
ProtClustDBCLSK2807689.

Enzyme and pathway databases

BioCycTROS309801:GI0S-772-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_THERP
AccessionPrimary (citable) accession number: B9KZ66
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways