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B9KZ42 (GCSPA_THERP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:trd_0753
OrganismThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) [Complete proteome] [HAMAP]
Taxonomic identifier309801 [NCBI]
Taxonomic lineageBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000147992

Sequences

Sequence LengthMass (Da)Tools
B9KZ42 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: E0D942FA925E5AD3

FASTA44849,229
        10         20         30         40         50         60 
MVFSPHTADD RARMLQEIGV ERLEELFAAI PASYRFPQLD LPPAISEAEI YRELLEWSMQ 

        70         80         90        100        110        120 
NFSTATTASF LGAGSYNHYV PAVVQQILWR GEFYTAYTPY QPEVSQGTLQ AIYEFQSLIC 

       130        140        150        160        170        180 
LLTGMEVSNA SMYDGATALA EGALLCVSPP RGRNKIVVAG TVHPHYRSVL RTYTRGLPVS 

       190        200        210        220        230        240 
IVEVPIPETL RLQPNDVAQY LDDATACLVV QYPNFYGRIE DLAGFAERAH AVGARLVVSV 

       250        260        270        280        290        300 
YPIALGLLRP PGELGADVVT GEGQCLGIPQ SFGGPALGIL ATRMELVRHL PGRLIGATVD 

       310        320        330        340        350        360 
REGKRGFVMV LQTREQHIRR EKATSNICTN QGLMALAATV YLSTLGKQGL RKVAELCYHK 

       370        380        390        400        410        420 
AHYLAERIAD LPAWNVIGDG PFFNEFAVRC PRDPREINAF LLERGIIGGL ALGDLVPGQQ 

       430        440 
DLMLLCATEL TTREQIDRLV EALREATA 

« Hide

References

[1]"Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum."
Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A.
PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27502 / DSM 5159 / P-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001275 Genomic DNA. Translation: ACM06083.1.
RefSeqYP_002521984.1. NC_011959.1.

3D structure databases

ProteinModelPortalB9KZ42.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309801.trd_0753.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM06083; ACM06083; trd_0753.
GeneID7356199.
KEGGtro:trd_0753.
PATRIC23912696. VBITheRos91376_0719.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMAGLEVANC.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycTROS309801:GI0S-746-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_THERP
AccessionPrimary (citable) accession number: B9KZ42
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families