B9KZ02 (B9KZ02_THERP) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123 EMBL ACM06038.1
Ordered Locus Names:	trd_0711

Organism

Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) [Complete proteome] [HAMAP]

Taxonomic identifier

309801 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Thermomicrobiales › Thermomicrobiaceae › Thermomicrobium

Protein attributes

Sequence length	662 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL ACM06038.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	528	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	620	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	B9KZ02 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: BC69B0C2A57E7274	FASTA	662	74,082
	10 20 30 40 50 60 MPDEIGTGAV GTIEGLLVET RRFPPPPEFA AQANINDPSV YERARQDPEG FWASIARELE 70 80 90 100 110 120 WDQPWQTVME WNPPWVKWFV GGKLNASVNC VDRHLKAGRR TKAAIIWEGE PGDERVLTYQ 130 140 150 160 170 180 DLYREVNRVA LALRRLGIEK GDRVAIYLPM IPELPIAMLA CARIGAPHSV VFGGFSADAL 190 200 210 220 230 240 ADRINDCQAK LLITADGGYR RGRVVPLKET ADRALDRCPS VEKVLVVRRI GESHQVTMQA 250 260 270 280 290 300 GRDLWWHEVL AGIREQYCPP ESLDSEHPLY ILYTSGTTGK PKGQLHTTGG YLTGVYITSK 310 320 330 340 350 360 WVFDLKPDDI YWCTADIGWV TGHSYIVYGP LANGATVVMY EGSPDWPDKD RFWDIVERRH 370 380 390 400 410 420 VTILYTSPTA IRQFMRWGPE YPARHDLSSL RLLGTVGEPI NPEAWMWYHE HIGRGRCPIV 430 440 450 460 470 480 DTWWQTETGM ILITPLPGLT TTKPGSATLP FPGIEPDILD EAGNSVPTGQ GGYLVIRRPW 490 500 510 520 530 540 PSISRTLWGD PDRYVKTYFS KYGPSIYVTG DGAKRDEDGY YWILGRVDDV LNVAGHRLGT 550 560 570 580 590 600 MELESALVGH PVVAEAAVIG VSHEIKGQVP VAFVSLRAGY TPSDSLAEEL RRHVAEVIGP 610 620 630 640 650 660 IARPERVIFV ADLPKTRSAK IMRRLLRDIA EGRVLGDTTT LTDPTVVEEI KRTWIAEHGE QE

References

[1]

"Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum." Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A. PLoS ONE 4:E4207-E4207(2009) [PubMed: 19148287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001275 Genomic DNA. Translation: ACM06038.1.
RefSeq	YP_002521944.1. NC_011959.1.
3D structure databases
ProteinModelPortal	B9KZ02.
ModBase	Search...
Protein-protein interaction databases
STRING	B9KZ02.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7355458.
GenomeReviews	Gene locus trd_0711 in contig CP001275_GR.
KEGG	tro:trd_0711.
PATRIC	23912622. VBITheRos91376_0684.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VISVSGH.
ProtClustDB	CLSK2482429.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B9KZ02_THERP

Accession

Primary (citable) accession number: B9KZ02

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)