B9KYX4 (RL1_THERP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L1

Gene names

Name:	rplA
Ordered Locus Names:	trd_0682

Organism

Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) [Complete proteome] [HAMAP]

Taxonomic identifier

309801 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chloroflexi › Thermomicrobia › Thermomicrobiales › Thermomicrobiaceae › Thermomicrobium › Thermomicrobium roseum

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release By similarity. HAMAP-Rule MF_01318 Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA By similarity. HAMAP-Rule MF_01318
Subunit structure	Part of the 50S ribosomal subunit By similarity.
Sequence similarities	Belongs to the ribosomal protein L1P family.

Ontologies

Keywords
Biological process	Translation regulation
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Repressor Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	regulation of translation Inferred from electronic annotation. Source: UniProtKB-KW translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	large ribosomal subunit Inferred from electronic annotation. Source: InterPro
Molecular_function	rRNA binding Inferred from electronic annotation. Source: HAMAP structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	50S ribosomal protein L1 HAMAP-Rule MF_01318		PRO_1000165708

Sequences

	Sequence		Length	Mass (Da)
	B9KYX4 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: FB10D1B7D5EA5DCA	FASTA	241	26,520
	10 20 30 40 50 60 MPKHGKKYLE ALKLVDVTRR YSPKEAVELV KKVAHADFDE SIDLHIKLNI DPRHADQNVR 70 80 90 100 110 120 GTVTLPHGTG RTPRVLVFAV GEAARIAEEA GADYVGSDDL IRQIEGGWLE FDAAIAMADQ 130 140 150 160 170 180 MGKVGPLGRI LGRRGLMPNP RTGTVVRNPE DLPAVIREIK GGRVEFRNDR TGNIHLQIGR 190 200 210 220 230 240 KSFTDQQLLE NLYVAVDAIA RARPQAVKGQ FFQSMTIAPT MGPGIPLDVA TTVEEARQFV T

References

[1]

"Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum." Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A. PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27502 / DSM 5159 / P-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001275 Genomic DNA. Translation: ACM06046.1.
RefSeq	YP_002521916.1. NC_011959.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	309801.trd_0682.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACM06046; ACM06046; trd_0682.
GeneID	7356427.
KEGG	tro:trd_0682.
PATRIC	23912566. VBITheRos91376_0657.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0081.
HOGENOM	HOG000207015.
KO	K02863.
OMA	AKGRYVK.
ProtClustDB	CLSK2807634.
Family and domain databases
Gene3D	3.30.190.20. 2 hits. 3.40.50.790. 1 hit.
HAMAP	MF_01318_B. Ribosomal_L1_B.
InterPro	IPR005878. Ribosom_L1_bac-type. IPR002143. Ribosomal_L1. IPR016094. Ribosomal_L1_2-a/b-sand. IPR016095. Ribosomal_L1_3-a/b-sand. IPR023673. Ribosomal_L1_CS. IPR023674. Ribosomal_L1_SF. [Graphical view]
Pfam	PF00687. Ribosomal_L1. 1 hit. [Graphical view]
PIRSF	PIRSF002155. Ribosomal_L1. 1 hit.
SUPFAM	SSF56808. Ribosomal_L1. 1 hit.
TIGRFAMs	TIGR01169. rplA_bact. 1 hit.
PROSITE	PS01199. RIBOSOMAL_L1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL1_THERP

Accession

Primary (citable) accession number: B9KYX4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program