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B9KYR9

- PNP_THERP

UniProt

B9KYR9 - PNP_THERP

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, trd_0623
Organism
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi498 – 4981Magnesium By similarity
Metal bindingi504 – 5041Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciTROS309801:GI0S-618-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:trd_0623
OrganismiThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Taxonomic identifieri309801 [NCBI]
Taxonomic lineageiBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium
ProteomesiUP000000447: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 790790Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000381924Add
BLAST

Proteomic databases

PRIDEiB9KYR9.

Interactioni

Protein-protein interaction databases

STRINGi309801.trd_0623.

Structurei

3D structure databases

ProteinModelPortaliB9KYR9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini565 – 62460KHAdd
BLAST
Domaini634 – 70269S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiGTENTIC.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9KYR9-1 [UniParc]FASTAAdd to Basket

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MPPIIHERSI EIAGRLLTIE TGRVAEQADG AVLVRYGETV VLTTVVGAKQ    50
PVEGIDFFPL TVEYEEKMYA AGKIPGGFFR REGKPSEAAI LAARLTDRPI 100
RPLFPKGYRN EVQVISTVLS ADQENEPDVL SIIGASAALT LSDIPWYGPV 150
GAVRIGELDG ELVINPTSHQ LLESRMDIVV AGTADAILMV EGQANEISED 200
RFIEAVVRAH QEIKRIVAVQ LELQAVAGKP KREFVPPQEN VELKQQIADY 250
LGDRLREAVF NPDKTLRVQA TAALREEVIA HFVPNEPLAI GTPQSGLPTA 300
KEVGDLFDSL VKELVRRTIL EQGERPDGRK PDEIREIWIQ VGLLPRPHGS 350
ALFTRGQTQV LTVCTLGTKE EEQFLDSLGI EETKRYMHHY NFPPFSTGEI 400
RRLRGPSRRD IGHGALAERA LLAVLPSEDE FPYTMRLVSE VLSSNGSTSM 450
ASVCGSSLAL MDAGVPIRKP VAGVAMGLVT DQTTGRYTIL TDIQGIEDAL 500
GDMDFKVAGT RDGITAIQMD IKVMGITPEI MRDALEQARR GRLFILDKMS 550
EVIDAPRPEM SPYAPRILRI KIKPEQIGEV IGPGGRVIRA IQEQTGTKIS 600
IEEDGTVFIS AANEDAARRA VREIERLTRV PEVGEIFYGR VVTIIPSGAF 650
VEILPGKDGF LHISEIAPER VRSVEDVLKV GQEINVMVIG VRPDGKINLS 700
RKALLEKEAA ERAATAQAPA DGRSHQPRAP QRPSGTAQPE RRPGPPTPRR 750
PEQRGPSRPP RPQAQRSTPP PGQYRIGDRL KELLGEDEPN 790
Length:790
Mass (Da):86,688
Last modified:March 24, 2009 - v1
Checksum:i6295D2A0E06D767B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001275 Genomic DNA. Translation: ACM05386.1.
RefSeqiWP_012642019.1. NC_011959.1.
YP_002521861.1. NC_011959.1.

Genome annotation databases

EnsemblBacteriaiACM05386; ACM05386; trd_0623.
GeneIDi7354872.
KEGGitro:trd_0623.
PATRICi23912454. VBITheRos91376_0604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001275 Genomic DNA. Translation: ACM05386.1 .
RefSeqi WP_012642019.1. NC_011959.1.
YP_002521861.1. NC_011959.1.

3D structure databases

ProteinModelPortali B9KYR9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309801.trd_0623.

Proteomic databases

PRIDEi B9KYR9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM05386 ; ACM05386 ; trd_0623 .
GeneIDi 7354872.
KEGGi tro:trd_0623.
PATRICi 23912454. VBITheRos91376_0604.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi GTENTIC.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci TROS309801:GI0S-618-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum."
    Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A.
    PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27502 / DSM 5159 / P-2.

Entry informationi

Entry nameiPNP_THERP
AccessioniPrimary (citable) accession number: B9KYR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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