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B9KYR9

- PNP_THERP

UniProt

B9KYR9 - PNP_THERP

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi498 – 4981MagnesiumUniRule annotation
    Metal bindingi504 – 5041MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciTROS309801:GI0S-618-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:trd_0623
    OrganismiThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
    Taxonomic identifieri309801 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium
    ProteomesiUP000000447: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 790790Polyribonucleotide nucleotidyltransferasePRO_0000381924Add
    BLAST

    Proteomic databases

    PRIDEiB9KYR9.

    Interactioni

    Protein-protein interaction databases

    STRINGi309801.trd_0623.

    Structurei

    3D structure databases

    ProteinModelPortaliB9KYR9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini565 – 62460KHUniRule annotationAdd
    BLAST
    Domaini634 – 70269S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218327.
    KOiK00962.
    OMAiGTENTIC.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9KYR9-1 [UniParc]FASTAAdd to Basket

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    MPPIIHERSI EIAGRLLTIE TGRVAEQADG AVLVRYGETV VLTTVVGAKQ    50
    PVEGIDFFPL TVEYEEKMYA AGKIPGGFFR REGKPSEAAI LAARLTDRPI 100
    RPLFPKGYRN EVQVISTVLS ADQENEPDVL SIIGASAALT LSDIPWYGPV 150
    GAVRIGELDG ELVINPTSHQ LLESRMDIVV AGTADAILMV EGQANEISED 200
    RFIEAVVRAH QEIKRIVAVQ LELQAVAGKP KREFVPPQEN VELKQQIADY 250
    LGDRLREAVF NPDKTLRVQA TAALREEVIA HFVPNEPLAI GTPQSGLPTA 300
    KEVGDLFDSL VKELVRRTIL EQGERPDGRK PDEIREIWIQ VGLLPRPHGS 350
    ALFTRGQTQV LTVCTLGTKE EEQFLDSLGI EETKRYMHHY NFPPFSTGEI 400
    RRLRGPSRRD IGHGALAERA LLAVLPSEDE FPYTMRLVSE VLSSNGSTSM 450
    ASVCGSSLAL MDAGVPIRKP VAGVAMGLVT DQTTGRYTIL TDIQGIEDAL 500
    GDMDFKVAGT RDGITAIQMD IKVMGITPEI MRDALEQARR GRLFILDKMS 550
    EVIDAPRPEM SPYAPRILRI KIKPEQIGEV IGPGGRVIRA IQEQTGTKIS 600
    IEEDGTVFIS AANEDAARRA VREIERLTRV PEVGEIFYGR VVTIIPSGAF 650
    VEILPGKDGF LHISEIAPER VRSVEDVLKV GQEINVMVIG VRPDGKINLS 700
    RKALLEKEAA ERAATAQAPA DGRSHQPRAP QRPSGTAQPE RRPGPPTPRR 750
    PEQRGPSRPP RPQAQRSTPP PGQYRIGDRL KELLGEDEPN 790
    Length:790
    Mass (Da):86,688
    Last modified:March 24, 2009 - v1
    Checksum:i6295D2A0E06D767B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001275 Genomic DNA. Translation: ACM05386.1.
    RefSeqiWP_012642019.1. NC_011959.1.
    YP_002521861.1. NC_011959.1.

    Genome annotation databases

    EnsemblBacteriaiACM05386; ACM05386; trd_0623.
    GeneIDi7354872.
    KEGGitro:trd_0623.
    PATRICi23912454. VBITheRos91376_0604.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001275 Genomic DNA. Translation: ACM05386.1 .
    RefSeqi WP_012642019.1. NC_011959.1.
    YP_002521861.1. NC_011959.1.

    3D structure databases

    ProteinModelPortali B9KYR9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309801.trd_0623.

    Proteomic databases

    PRIDEi B9KYR9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM05386 ; ACM05386 ; trd_0623 .
    GeneIDi 7354872.
    KEGGi tro:trd_0623.
    PATRICi 23912454. VBITheRos91376_0604.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218327.
    KOi K00962.
    OMAi GTENTIC.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci TROS309801:GI0S-618-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum."
      Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A.
      PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27502 / DSM 5159 / P-2.

    Entry informationi

    Entry nameiPNP_THERP
    AccessioniPrimary (citable) accession number: B9KYR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3