B9KYK0 (DCD_THERP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	trd_0546

Organism

Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) [Complete proteome] [HAMAP]

Taxonomic identifier

309801 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Chloroflexi › Thermomicrobia › Thermomicrobiales › Thermomicrobiaceae › Thermomicrobium › Thermomicrobium roseum

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP-Rule MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP-Rule MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dUMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine ribonucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	dCTP deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Deoxycytidine triphosphate deaminase HAMAP-Rule MF_00146		PRO_1000123159

Sequences

	Sequence		Length	Mass (Da)
	B9KYK0 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 411A20F9FBD01222	FASTA	197	21,751
	10 20 30 40 50 60 MILSDRDIIA ALKSGRIKIT PEPDLETQLG ACSIDLHLGN TFMVFEHSRF SYIDPRQPQS 70 80 90 100 110 120 IGDAMRTIVV PDGEPFIMQA GDFALASTRE YIELADDLVG RLEGRSSIAR LGITVHSTAA 130 140 150 160 170 180 LFEPGWAGTA TMELSNLGRM AVALYPGMRI CSFTFEQLSS PAMVPYRMKR GNKYAGQKDP 190 KPSRLAEELS LEQLRGR

References

[1]

"Complete genome sequence of the aerobic CO-oxidizing thermophile Thermomicrobium roseum." Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A., Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L., Eisen J.A. PLoS ONE 4:E4207-E4207(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27502 / DSM 5159 / P-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001275 Genomic DNA. Translation: ACM04845.1.
RefSeq	YP_002521792.1. NC_011959.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	309801.trd_0546.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACM04845; ACM04845; trd_0546.
GeneID	7355896.
KEGG	tro:trd_0546.
PATRIC	23912304. VBITheRos91376_0534.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0717.
HOGENOM	HOG000228601.
KO	K01494.
OMA	RQDAKYK.
ProtClustDB	CLSK2807580.
Enzyme and pathway databases
UniPathway	UPA00610; UER00665.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase.
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. dCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_THERP

Accession

Primary (citable) accession number: B9KYK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program