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Protein

dCTP deaminase

Gene

dcd

Organism
Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei133Proton donor/acceptorUniRule annotation1
Binding sitei166dCTPUniRule annotation1
Binding sitei177dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 110dCTP bindingUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciTROS309801:G1GU8-509-MONOMER
UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:trd_0546
OrganismiThermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2)
Taxonomic identifieri309801 [NCBI]
Taxonomic lineageiBacteriaChloroflexiThermomicrobialesThermomicrobiaceaeThermomicrobium
Proteomesi
  • UP000000447 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001231591 – 197dCTP deaminaseAdd BLAST197

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi309801.trd_0546

Structurei

3D structure databases

ProteinModelPortaliB9KYK0
SMRiB9KYK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP Bacteria
COG0717 LUCA
HOGENOMiHOG000228601
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG091H021I

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

B9KYK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDRDIIA ALKSGRIKIT PEPDLETQLG ACSIDLHLGN TFMVFEHSRF
60 70 80 90 100
SYIDPRQPQS IGDAMRTIVV PDGEPFIMQA GDFALASTRE YIELADDLVG
110 120 130 140 150
RLEGRSSIAR LGITVHSTAA LFEPGWAGTA TMELSNLGRM AVALYPGMRI
160 170 180 190
CSFTFEQLSS PAMVPYRMKR GNKYAGQKDP KPSRLAEELS LEQLRGR
Length:197
Mass (Da):21,751
Last modified:March 24, 2009 - v1
Checksum:i411A20F9FBD01222
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001275 Genomic DNA Translation: ACM04845.1
RefSeqiWP_012641950.1, NC_011959.1

Genome annotation databases

EnsemblBacteriaiACM04845; ACM04845; trd_0546
KEGGitro:trd_0546

Similar proteinsi

Entry informationi

Entry nameiDCD_THERP
AccessioniPrimary (citable) accession number: B9KYK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: April 25, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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