ID   B9KXM0_THERP            Unreviewed;       693 AA.
AC   B9KXM0;
DT   24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   24-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=DNA polymerase III, epsilon subunit {ECO:0000313|EMBL:ACM05471.1};
GN   OrderedLocusNames=trd_0207 {ECO:0000313|EMBL:ACM05471.1};
OS   Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2).
OC   Bacteria; Thermomicrobiota; Thermomicrobia; Thermomicrobiales;
OC   Thermomicrobiaceae; Thermomicrobium.
OX   NCBI_TaxID=309801 {ECO:0000313|EMBL:ACM05471.1, ECO:0000313|Proteomes:UP000000447};
RN   [1] {ECO:0000313|EMBL:ACM05471.1, ECO:0000313|Proteomes:UP000000447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27502 / DSM 5159 / P-2
RC   {ECO:0000313|Proteomes:UP000000447};
RX   PubMed=19148287; DOI=10.1371/journal.pone.0004207;
RA   Wu D., Raymond J., Wu M., Chatterji S., Ren Q., Graham J.E., Bryant D.A.,
RA   Robb F., Colman A., Tallon L.J., Badger J.H., Madupu R., Ward N.L.,
RA   Eisen J.A.;
RT   "Complete genome sequence of the aerobic CO-oxidizing thermophile
RT   Thermomicrobium roseum.";
RL   PLoS ONE 4:E4207-E4207(2009).
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DR   EMBL; CP001275; ACM05471.1; -; Genomic_DNA.
DR   AlphaFoldDB; B9KXM0; -.
DR   STRING; 309801.trd_0207; -.
DR   KEGG; tro:trd_0207; -.
DR   eggNOG; COG0322; Bacteria.
DR   eggNOG; COG0847; Bacteria.
DR   HOGENOM; CLU_397351_0_0_0; -.
DR   OrthoDB; 9804933at2; -.
DR   Proteomes; UP000000447; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProt.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   CDD; cd06127; DEDDh; 1.
DR   CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR   Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006054; DnaQ.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   NCBIfam; TIGR00573; dnaq; 1.
DR   PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR   PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   Pfam; PF02151; UVR; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR   SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
PE   4: Predicted;
FT   DOMAIN          291..370
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000259|PROSITE:PS50164"
FT   DOMAIN          482..517
FT                   /note="UVR"
FT                   /evidence="ECO:0000259|PROSITE:PS50151"
FT   REGION          644..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        645..672
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   693 AA;  77438 MW;  E8D4DB9040100EE8 CRC64;
     MSDQPVEPAY DRLRSRARQL LLARGGIASE EQLIEGLFGS LGNRRLWAPF LAQLLETDAE
     IVRRPDGTWA LRRRPLVPSR GWPRSFVALD VETTGLRPAR HRIIEIGAVR YEDGCCVERF
     SVLVNPHRRL PVYIVRLTGI RDEDLLTAPS FVDVAAAFRV FLGESTVIGY NVGFDLDFLN
     AELRRIGQGP LPNPALDVLP LARALLTANG RYDLDAICRS IGLARGTRHR ALPDAEATAV
     LYLHLVERAE QVGYRSPSDL QPAATRRTIV VEPVARGRAV LDQRLLADTP ELPGVYLMRD
     ALGRVLYVGK ARNLRQRVRS YFSQPLGYTR KMDGLLESVA EIETVVTGSE LEALLLESQF
     VQRYKPPYNT QLRNHEAYPY VKVELGRPWP RLMLARQRDD DDAVYVGPFR STAAARSVVE
     LLHQLLPLRT CHRSFRDARS YGRPCLQLTL GRCIGPCTGC VTPDEYRALV DCALRYLSGE
     TSVVVERAQQ LLADAVERLD FERAARLRDL LRRSEELVFS HRLVRQTISG RPCVIVTPCP
     ETGDRAFLLI VAGRLWARVV ADPREHDAAV AARLGAAWER AQQAAPWTLD QDSLDAAVII
     ARWLSEHAED PTVFFLEHPV DWLALVRNGR SLPASAFAVH APVDDENGTT KRTRGADSER
     GTQCEGTPGK HRRARPSLHA LRSMADPHSG GAR
//