B9KTD9 (IOLG_RHOSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	RSKD131_3457

Organism

Rhodobacter sphaeroides (strain KD131 / KCTC 12085) [Complete proteome] [HAMAP]

Taxonomic identifier

557760 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter › Rhodobacter sphaeroides

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP-Rule MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP-Rule MF_01671
Subunit structure	Homotetramer By similarity. HAMAP-Rule MF_01671
Sequence similarities	Belongs to the Gfo/Idh/MocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Inositol 2-dehydrogenase HAMAP-Rule MF_01671		PRO_1000187320

Sequences

	Sequence		Length	Mass (Da)
	B9KTD9 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 7995F14670D96FF7	FASTA	334	36,099
	10 20 30 40 50 60 MTLRIGIIGT GAIGTDHARR INRVLSGAEV TAVTDVNRDN AEACVAGVAP GAQILGSAEE 70 80 90 100 110 120 VIAASDAVLV CSWGAAHEAQ VLAAIAAGKP CFCEKPLATE AYGARRIVEA EEAMGRRLVQ 130 140 150 160 170 180 VGFMRRYDRG YVALKETVRT RLGPPLMIHA AHRNPTVPGR YRTPMAIHDT LIHEIDVLRW 190 200 210 220 230 240 LLDDEYVSAQ VIFPRATRHT HAGLRDPQIV LLETAKGVRI DVEIFVNCRY GYDIQCEVVG 250 260 270 280 290 300 EEGTARLPEP TAIPTRLGAV FGQPILMDWK DRFIDSYDVE LQDFLKAAAQ GTAAGPSAWD 310 320 330 GYVAAITADV CAQAQERPGA ILPVTLPARP ALYA

References

[1]	"Complete genome sequence of Rhodobacter sphaeroides KD131." Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K. J. Bacteriol. 191:1118-1119(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KD131 / KCTC 12085.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001151 Genomic DNA. Translation: ACM03317.1.
RefSeq	YP_002520390.1. NC_011958.1.
3D structure databases
ProteinModelPortal	B9KTD9.
ModBase	Search...
Protein-protein interaction databases
STRING	557760.RSKD131_3457.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACM03317; ACM03317; RSKD131_3457.
GeneID	7353453.
KEGG	rsk:RSKD131_3457.
PATRIC	23176913. VBIRhoSph125910_0350.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HOG000227439.
KO	K00010.
OMA	YDVELQD.
ProtClustDB	CLSK800746.
Enzyme and pathway databases
BioCyc	RSPH557760:GH1P-3509-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_01671. IolG.
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_RHOSK

Accession

Primary (citable) accession number: B9KTD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	May 29, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program