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B9KR57 (B9KR57_RHOSK) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:RSKD131_0924
OrganismRhodobacter sphaeroides (strain KD131 / KCTC 12085) [Complete proteome] [HAMAP]
Taxonomic identifier557760 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region246 – 2505ACP-binding By similarity HAMAP MF_01815

Sites

Active site1091 By similarity HAMAP MF_01815
Active site2451 By similarity HAMAP MF_01815
Active site2751 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B9KR57 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: B2327C512D7AFCB6

FASTA31833,648
        10         20         30         40         50         60 
MVRGVGHYLP DRVVPNSELE AIVETTDEWI RTRSGIERRH FAAEGQTTSD LAARAARAAL 

        70         80         90        100        110        120 
EDAGLQPDDI DTLIVATSTA DLTFPSAATM VQAALGMTRG FAFDVQAVCA GFVYALANAD 

       130        140        150        160        170        180 
ALIRSGQAQR VLVIGAETFS RLMDWNDRAT CVLFGDGAGA VVLEGTESAG TSADRGILAT 

       190        200        210        220        230        240 
DLHSDGRFKD LLYVDGGSST GTTGHLRMQG REVFRHAVEK LAETAHTALE KAGLGAGDVD 

       250        260        270        280        290        300 
WIVPHQANLR IISATAQRMQ VPMDRVILTV QDHGNTSAAS IPLALSVGKA RGQIKEGDLL 

       310 
VTEAIGGGLA WGSVVLRW

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References

[1]"Complete genome sequence of Rhodobacter sphaeroides KD131."
Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K.
J. Bacteriol. 191:1118-1119(2009) [PubMed: 19028901] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001150 Genomic DNA. Translation: ACM00784.1.
RefSeqYP_002525285.1. NC_011963.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB9KR57.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7360657.
GenomeReviewsGene locus RSKD131_0924 in contig CP001150_GR.
KEGGrsk:RSKD131_0924.
PATRIC23180946. VBIRhoSph125910_2338.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMADAYIRGG.
ProtClustDBCLSK933877.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB9KR57_RHOSK
AccessionPrimary (citable) accession number: B9KR57
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info