B9KPH4 (HIS8_RHOSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	RSKD131_0607

Organism

Rhodobacter sphaeroides (strain KD131 / KCTC 12085) [Complete proteome] [HAMAP]

Taxonomic identifier

557760 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_1000149111
Amino acid modifications
	Modified residue	219	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9KPH4 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 911DF7E157DCFAAD	FASTA	361	39,179
	10 20 30 40 50 60 MSDAIRPQPG ILDIALYEGG KSHVAGIQNA LKLSSNENPF GPSPKAKEAF LRSVHTLHRY 70 80 90 100 110 120 PSTDHAGLRH AIAEVHGLDP ARVICGVGSD EIITFLCQAY AGPHTDVVFT EHGFLMYRIS 130 140 150 160 170 180 ALAVGANPVE VPERERTTDV DAILAACTPH TRLVFLANPN NPTGTMIGQA DLARLAAGLP 190 200 210 220 230 240 AQAILVLDGA YAEYVPGYDA GLALIEERGN VVMTRTFSKI YGLGGLRVGW GYGPKSIIDV 250 260 270 280 290 300 LNRIRGPFNL STTQLETAEA AVRDQDHVAR CRADNARWRI WLAEALAEIG VPSDTSMANF 310 320 330 340 350 360 ILARFSDTEE AEACDLHLQT QGLIVRRVAG YKLPHCLRIT IGDEASCRRV AHAIGQFKRM R

References

[1]	"Complete genome sequence of Rhodobacter sphaeroides KD131." Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K. J. Bacteriol. 191:1118-1119(2009) [PubMed: 19028901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KD131 / KCTC 12085.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001150 Genomic DNA. Translation: ACM00467.1.
RefSeq	YP_002524968.1. NC_011963.1.
3D structure databases
ProteinModelPortal	B9KPH4.
ModBase	Search...
Protein-protein interaction databases
STRING	B9KPH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7357833.
GenomeReviews	Gene locus RSKD131_0607 in contig CP001150_GR.
KEGG	rsk:RSKD131_0607.
PATRIC	23180302. VBIRhoSph125910_2020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	YPSTDHA.
ProtClustDB	PRK02731.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_RHOSK

Accession

Primary (citable) accession number: B9KPH4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program