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B9KP36

- PUR9_RHOSK

UniProt

B9KP36 - PUR9_RHOSK

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Rhodobacter sphaeroides (strain KD131 / KCTC 12085)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciRSPH557760:GH1P-2530-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:RSKD131_2498
OrganismiRhodobacter sphaeroides (strain KD131 / KCTC 12085)
Taxonomic identifieri557760 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000001597: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHPRO_1000122969Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557760.RSKD131_2498.

Structurei

3D structure databases

ProteinModelPortaliB9KP36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B9KP36-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNLVPVGRA LLSVSDKSGL LDLARALADL EVELISTGGT AAALRAAGLK
60 70 80 90 100
VRDVAEVTGF PEMMDGRVKT LHPMVHGGLL ALRDDDEHLV AMAAHGIEPI
110 120 130 140 150
DLLVVNLYPF EAAVARGASY DDCIENIDIG GPAMIRAAAK NHRFVNVVTD
160 170 180 190 200
TADYKALLDE LRAHDGATRL SFRQKLALTA YARTAAYDTA VSTWMAGALK
210 220 230 240 250
AEAPRRRSFA GTLAQTMRYG ENPHQKAAFY TDGSARPGVA TAKQWQGKEL
260 270 280 290 300
SYNNINDTDA AFELVAEFDP AEGPACVIVK HANPCGVARG ATLAEAYARA
310 320 330 340 350
FDCDRVSAFG GIIALNQPLD AATAEKITEI FTEVVIAPGA DEEARAIFAA
360 370 380 390 400
KKNLRLLTTE ALPDPLAPGL AFKQVAGGFL VQDRDAGHVD ALDLKVVTKR
410 420 430 440 450
APSDAELADL LFAWTVAKHV KSNAIVYVKD GATVGVGAGQ MSRVDSTRIA
460 470 480 490 500
ARKSQDMAQA LGLAQPLTQG SVVASDAFFP FADGLLAAAE AGATAIIQPG
510 520
GSMRDDEVIA AADEAGLAMV FTGQRHFRH
Length:529
Mass (Da):55,829
Last modified:March 24, 2009 - v1
Checksum:i085069F91C150C9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001150 Genomic DNA. Translation: ACM02358.1.
RefSeqiYP_002526859.1. NC_011963.1.

Genome annotation databases

EnsemblBacteriaiACM02358; ACM02358; RSKD131_2498.
GeneIDi7359196.
KEGGirsk:RSKD131_2498.
PATRICi23184126. VBIRhoSph125910_3904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001150 Genomic DNA. Translation: ACM02358.1 .
RefSeqi YP_002526859.1. NC_011963.1.

3D structure databases

ProteinModelPortali B9KP36.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557760.RSKD131_2498.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM02358 ; ACM02358 ; RSKD131_2498 .
GeneIDi 7359196.
KEGGi rsk:RSKD131_2498.
PATRICi 23184126. VBIRhoSph125910_3904.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci RSPH557760:GH1P-2530-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rhodobacter sphaeroides KD131."
    Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K.
    J. Bacteriol. 191:1118-1119(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KD131 / KCTC 12085.

Entry informationi

Entry nameiPUR9_RHOSK
AccessioniPrimary (citable) accession number: B9KP36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 1, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3