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B9KNU3 (GCSP_RHOSK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:RSKD131_0511
OrganismRhodobacter sphaeroides (strain KD131 / KCTC 12085) [Complete proteome] [HAMAP]
Taxonomic identifier557760 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length956 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 956956Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000147969

Amino acid modifications

Modified residue6971N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B9KNU3 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 04DE9600138B50B3

FASTA956103,086
        10         20         30         40         50         60 
MSFTPTDYNA YDFANRRHIG PSPSEMEEML RVVGVSSLDQ LIEETVPASI RQETPLDWAP 

        70         80         90        100        110        120 
LAEHELLARM REVAAKNRVM TSLIGQGYYG TVTPPAIQRN ILENPAWYTA YTPYQPEIAQ 

       130        140        150        160        170        180 
GRLEALLNYQ TMVADLTGLP VANASLLDEA TAAAEAMTMA ERASKSKARA FFVDADCHPQ 

       190        200        210        220        230        240 
TISVIRTRAE PLGIEVIVGH PAQLVPEDVF GALFQYPGTY GLVRDFTRDI AALHEAKALA 

       250        260        270        280        290        300 
VVATDLLALC LLKEPGAMGA DIAIGSSQRF GVPMGYGGPH AAFMSCKDDL KRSMPGRLVG 

       310        320        330        340        350        360 
VSVDARGNKA YRLALQTREQ HIRREKATSN VCTAQALLAV MASFYAVFHG PRGLRAIAER 

       370        380        390        400        410        420 
VHLNTVRLAT ALKEAGARVS PEAFFDTITV EVGVGQAGIL AAARHRGINL RKVGRDRVGI 

       430        440        450        460        470        480 
SLDETTDAGV IARVLDAFGI HEPAPAKVGL GFPEPLLRET GYLSHPVFQM NRAESEMMRY 

       490        500        510        520        530        540 
MRRLSDRDLA LDRAMIPLGS CTMKLNAAAE MMPITWPEFG TLHPFAPADQ AAGYHEAIGD 

       550        560        570        580        590        600 
LAQRLCRITG YDAMSMQPNS GAQGEYAGLL TILAYHRARG DAERTICLIP VSAHGTNPAS 

       610        620        630        640        650        660 
AQMAGMKVVV VKSAPNGDVD LEDFRDKAAA AGDRLAACMI TYPSTHGVFE ETVREVCRIT 

       670        680        690        700        710        720 
HEHGGQVYID GANMNAMVGL VQPGAIGGDV SHLNLHKTFA IPHGGGGPGM GPIGVKAHLA 

       730        740        750        760        770        780 
PYLPGHPEVT GPLTGGHDEA ADEGPVSAAP YGSASILLIS WAYCLMMGGE GLTQATRVAI 

       790        800        810        820        830        840 
LNANYIAARL RGAYKVLFMG NRGRVAHECI LDTRPFAEAG VTVDDIAKRL IDNGFHAPTM 

       850        860        870        880        890        900 
SWPVPGTLMV EPTESETKAE IDRFVAALLA IREEIRAVEE GEIAAADSPL RHAPHTVEDL 

       910        920        930        940        950 
VADWDRKYPR EQGCFPPGSF RVDKYWPPVG RVDNAWGDRN LVCTCPPVES YSIAAQ 

« Hide

References

[1]"Complete genome sequence of Rhodobacter sphaeroides KD131."
Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K.
J. Bacteriol. 191:1118-1119(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KD131 / KCTC 12085.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001150 Genomic DNA. Translation: ACM00371.1.
RefSeqYP_002524872.1. NC_011963.1.

3D structure databases

ProteinModelPortalB9KNU3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING557760.RSKD131_0511.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM00371; ACM00371; RSKD131_0511.
GeneID7358533.
KEGGrsk:RSKD131_0511.
PATRIC23180110. VBIRhoSph125910_1924.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycRSPH557760:GH1P-517-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_RHOSK
AccessionPrimary (citable) accession number: B9KNU3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families