B9KNP8 (B9KNP8_RHOSK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histidinol dehydrogenase PIRNR PIRNR000099
Short name=HDH PIRNR PIRNR000099
EC=1.1.1.23 PIRNR PIRNR000099

Gene names

Ordered Locus Names:

RSKD131_0466

Organism

Rhodobacter sphaeroides (strain KD131 / KCTC 12085) [Complete proteome] [HAMAP]

Taxonomic identifier

557760 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. PIRNR PIRNR000099 SAAS SAAS001692
Catalytic activity	L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. PIRNR PIRNR000099 SAAS SAAS001692
Cofactor	Binds 1 zinc ion per subunit By similarity. SAAS SAAS001692
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. PIRNR PIRNR000099 SAAS SAAS001692
Sequence similarities	Belongs to the histidinol dehydrogenase family. PIRNR PIRNR000099 RuleBase RU004175

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis PIRNR PIRNR000099 SAAS SAAS001692
Ligand	Metal-binding SAAS SAAS001692 NAD PIRNR PIRNR000099 SAAS SAAS001692 Zinc SAAS SAAS001692
Molecular function	Oxidoreductase PIRNR PIRNR000099 SAAS SAAS001692
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	334	1	Proton acceptor By similarity PIRSR PIRSR000099-1
	Active site	335	1	Proton acceptor By similarity PIRSR PIRSR000099-1

Sequences

	Sequence		Length	Mass (Da)
	B9KNP8 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 51E091F6A1455CF9	FASTA	441	46,940
	10 20 30 40 50 60 MVQVNFQVLA ELDAAGRAAL LRRSETDLSM FLEKVGPILE AVRTEGDSAL VRFGRELDRA 70 80 90 100 110 120 EGLTREGLKV TEAEFDEAFG LVEPEIVEAI RFAIGNIRTF HEEQAPEPMW LKELRPGAFA 130 140 150 160 170 180 GDRFTPIRSV ALYVPRGKGS FPSVTMMTSV PAVVAQVPQI AIFTPPAPDG RVDAATLVAA 190 200 210 220 230 240 RLAGVETVYK VGGAQAVAAA AYGTETVTPA LKIVGPGSPW VVAAKRLLAG VIDPGLPAGP 250 260 270 280 290 300 SESIILADET VHGGLAALDL LIEAEHGPDS SAWLVTHSRQ VAEEALAALP GHWAAMTPQR 310 320 330 340 350 360 VDFSQAVLCG RAGGIVLTGS AEESHAFVND YAPEHLQILS EKPFEHLGRI TEAAEVLMGP 370 380 390 400 410 420 HTPITIANFC LGPNAVLPTS RGARTWGPLS VHDFLRRSSV GYVTAPAYPE LAEVAKRLAE 430 440 YEGFSSHANA VGPMRDAYLK R

References

[1]	"Complete genome sequence of Rhodobacter sphaeroides KD131." Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K. J. Bacteriol. 191:1118-1119(2009) [PubMed: 19028901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001150 Genomic DNA. Translation: ACM00326.1.
RefSeq	YP_002524827.1. NC_011963.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B9KNP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7358488.
GenomeReviews	Gene locus RSKD131_0466 in contig CP001150_GR.
KEGG	rsk:RSKD131_0466.
PATRIC	23180020. VBIRhoSph125910_1880.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	KIVGPGS.
ProtClustDB	PRK00877.
Family and domain databases
HAMAP	MF_01024. HisD. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR001692. Histidinol_DH_CS. IPR022695. Histidinol_DH_monofunct. IPR012131. Hstdl_DH. [Graphical view]
KO	K00013.
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000099. Histidinol_dh. 1 hit.
PRINTS	PR00083. HOLDHDRGNASE.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00069. HisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B9KNP8_RHOSK

Accession

Primary (citable) accession number: B9KNP8

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)