B9KMR6 (PUR5_RHOSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase
EC=6.3.3.1

Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase

Gene names

Name:	purM
Ordered Locus Names:	RSKD131_0268

Organism

Rhodobacter sphaeroides (strain KD131 / KCTC 12085) [Complete proteome] [HAMAP]

Taxonomic identifier

557760 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter › Rhodobacter sphaeroides

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741		PRO_1000148292

Sequences

	Sequence		Length	Mass (Da)
	B9KMR6 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: AA6A098E78683C5A	FASTA	348	35,748
	10 20 30 40 50 60 MAEQQKGLTY ADAGVDIDAG NALVERIKPA AKRTARPGTV SGLGGFGALF DLKAAGYHDP 70 80 90 100 110 120 VLVAATDGVG TKLRIAIDTG EVDTIGIDLV AMCVNDLVCQ GAEPLFFLDY FATGKLEVAQ 130 140 150 160 170 180 AARIIEGIAE GCAASGCALI GGETAEMPGM YHKGDFDLAG FAVGAMERGA DLPQGVAEGD 190 200 210 220 230 240 VLLGLGSNGV HSNGYSFVRK VVELSGLGWD APAPFGGDSL GRALLAPTRL YVKQALAAVR 250 260 270 280 290 300 AGGVHALAHI TGGGLTENLP RVLPEGLGAR IDLSAWELPS VFRWLAETAS MAEPELLKTF 310 320 330 340 NCGIGMIVVV AADRADEIAA LLAAEGETVT RIGEVIAGEG VSYDGRLL

References

[1]	"Complete genome sequence of Rhodobacter sphaeroides KD131." Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K. J. Bacteriol. 191:1118-1119(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KD131 / KCTC 12085.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001150 Genomic DNA. Translation: ACM00128.1.
RefSeq	YP_002524629.1. NC_011963.1.
3D structure databases
ProteinModelPortal	B9KMR6.
ModBase	Search...
Protein-protein interaction databases
STRING	557760.RSKD131_0268.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACM00128; ACM00128; RSKD131_0268.
GeneID	7358835.
KEGG	rsk:RSKD131_0268.
PATRIC	23179636. VBIRhoSph125910_1690.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0150.
HOGENOM	HOG000229090.
KO	K01933.
OMA	PRVLPKH.
ProtClustDB	PRK05385.
Enzyme and pathway databases
BioCyc	RSPH557760:GH1P-267-MONOMER.
UniPathway	UPA00074; UER00129.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B.
InterPro	IPR010918. AIR_synth_C_dom. IPR000728. AIR_synth_N_dom. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
SUPFAM	SSF56042. AIR_synth_C. 1 hit. SSF55326. PurM_N-like. 1 hit.
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_RHOSK

Accession

Primary (citable) accession number: B9KMR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program