UniProtKB - B9KMH8 (SYL_RHOSK)
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Protein
Leucine--tRNA ligase
Gene
leuS
Organism
Rhodobacter sphaeroides (strain KD131 / KCTC 12085)
Status
Functioni
Catalytic activityi
ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 622 | ATPUniRule annotation | 1 |
GO - Molecular functioni
- aminoacyl-tRNA editing activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- leucine-tRNA ligase activity Source: UniProtKB-EC
GO - Biological processi
- leucyl-tRNA aminoacylation Source: InterPro
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)Alternative name(s): Leucyl-tRNA synthetaseUniRule annotation Short name: LeuRSUniRule annotation |
Gene namesi | Name:leuSUniRule annotation Ordered Locus Names:RSKD131_2209 |
Organismi | Rhodobacter sphaeroides (strain KD131 / KCTC 12085) |
Taxonomic identifieri | 557760 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000199221 | 1 – 847 | Leucine--tRNA ligaseAdd BLAST | 847 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 41 – 51 | "HIGH" regionAdd BLAST | 11 | |
Motifi | 619 – 623 | "KMSKS" region | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000200747. |
KOi | K01869. |
OMAi | TFMVLAP. |
Family and domain databases
Gene3Di | 3.40.50.620. 2 hits. 3.90.740.10. 1 hit. |
HAMAPi | MF_00049_B. Leu_tRNA_synth_B. 1 hit. |
InterProi | View protein in InterPro IPR001412. aa-tRNA-synth_I_CS. IPR002300. aa-tRNA-synth_Ia. IPR002302. Leu-tRNA-ligase. IPR025709. Leu_tRNA-synth_edit. IPR013155. M/V/L/I-tRNA-synth_anticd-bd. IPR015413. Methionyl/Leucyl_tRNA_Synth. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_Ia_anticodon-bd. IPR009008. Val/Leu/Ile-tRNA-synth_edit. |
PANTHERi | PTHR43740. PTHR43740. 1 hit. |
Pfami | View protein in Pfam PF08264. Anticodon_1. 1 hit. PF00133. tRNA-synt_1. 2 hits. PF13603. tRNA-synt_1_2. 1 hit. PF09334. tRNA-synt_1g. 1 hit. |
PRINTSi | PR00985. TRNASYNTHLEU. |
SUPFAMi | SSF47323. SSF47323. 1 hit. SSF50677. SSF50677. 1 hit. |
TIGRFAMsi | TIGR00396. leuS_bact. 1 hit. |
PROSITEi | View protein in PROSITE PS00178. AA_TRNA_LIGASE_I. 1 hit. |
i Sequence
Sequence statusi: Complete.
B9KMH8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRYDPAATE SRWQAAWDAA GVFTARHDPA RPKYYVLEMF PYPSGRIHMG
60 70 80 90 100
HVRNYTMGDV VARQKAAAGF SVLHPMGWDA FGMPAENAAM ERGGHPKDWT
110 120 130 140 150
YGNIADMRAQ MKPLGLSIDW SREFATCDPE YYGQQQAMFI DMMEAGLVYR
160 170 180 190 200
KNAVVNWDPV DMTVLANEQV IDGKGWRSGA PVVRRELTQW FFRISDYAGE
210 220 230 240 250
LLEALDTLKD WPEKVRLMQA NWIGQSRGLQ FAFSTAGAPE GFDRLEVYTT
260 270 280 290 300
RPDTLMGASF AAISPDHPLA RHLERHDAEV AEFVAECRRV GTSEEALEKA
310 320 330 340 350
EKKGFDTGLR VRHPFDTAWE LPVYIANFIL MDYGTGAIFG CPAHDQRDFE
360 370 380 390 400
FATKYGLPIR PVFLPEGTEE TALAEAFVPM KSERVHYIRG FAGAEVQSGE
410 420 430 440 450
EGVAAAIDFC ESQGVGRGVT NYRLRDWGIS RQRYWGCPIP VIHCETCGVV
460 470 480 490 500
PEAKENLPVR LPDDVSFDVP GNPLDRHPTW RDCTCPKCGA KARRETDTMD
510 520 530 540 550
TFVDSSWYYA RFTAPRAATP TDAEEADYWM NVDQYIGGIE HAILHLLYSR
560 570 580 590 600
FFARAMQKTG HLPAKAIEPF NALFTQGMVT HEIYLTRDAA GRPVYHLPED
610 620 630 640 650
VTDGKLADGT PVEIIPSAKM SKSKKNVVDP MNIIRQFGAD TARWFVMSDS
660 670 680 690 700
PPERDVEWTA SGAEAASKHL HRVWRLADEI SRADGEANAE DGALDKATAR
710 720 730 740 750
AIAEVTQGVE GFAFNKAIAK LYEFTNTLSR SGAGAEAKKR AMRTMAQLMS
760 770 780 790 800
PMVPHLAEEV WAMLGGEGLV AQAAWPKADP ALLIDDTVTL PIQVNGKRRG
810 820 830 840
EITVPKEMAA SEVEKLVLAD EAVQRALGGA APKKLIVVPG RIVNVVI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001150 Genomic DNA. Translation: ACM02069.1. |
RefSeqi | WP_015921266.1. NC_011963.1. |
Genome annotation databases
EnsemblBacteriai | ACM02069; ACM02069; RSKD131_2209. |
KEGGi | rsk:RSKD131_2209. |
Similar proteinsi
Entry informationi
Entry namei | SYL_RHOSK | |
Accessioni | B9KMH8Primary (citable) accession number: B9KMH8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | March 24, 2009 | |
Last modified: | January 31, 2018 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |