leuS

Functionⁱ

Catalytic activityⁱ

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Binding siteⁱ	622 – 622	1	ATPUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00049

Enzyme and pathway databases

BioCycⁱ	RSPH557760:GH1P-2236-MONOMER.

BioCycⁱ

RSPH557760:GH1P-2236-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Leucine--tRNA ligaseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00049 (EC:6.1.1.4UniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00049 ) Alternative name(s): Leucyl-tRNA synthetaseUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00049 Short name: LeuRSUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00049
Gene namesⁱ	Name:leuSUniRule annotation Manual assertion according to rulesⁱ HAMAP-Rule:MF_00049 Ordered Locus Names:RSKD131_2209
Organismⁱ	Rhodobacter sphaeroides (strain KD131 / KCTC 12085)
Taxonomic identifierⁱ	557760 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter › Rhodobacter sphaeroides
Proteomesⁱ	UP000001597: Chromosome 1

Subcellular locationⁱ

Cytoplasm UniRule annotation

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 847	847	Leucine--tRNA ligase		PRO_1000199221	Add BLAST

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	557760.RSKD131_2209.

STRINGⁱ

557760.RSKD131_2209.

Family & Domainsⁱ

Motif

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Motifⁱ	41 – 51	11	"HIGH" region			Add BLAST
Motifⁱ	619 – 623	5	"KMSKS" region

Sequence similaritiesⁱ

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	COG0495.
HOGENOMⁱ	HOG000200747.
KOⁱ	K01869.
OMAⁱ	QSSWYFL.
OrthoDBⁱ	EOG63Z74X.

Family and domain databases

Gene3Dⁱ	1.10.730.10. 1 hit. 3.40.50.620. 3 hits. 3.90.740.10. 1 hit.
HAMAPⁱ	MF_00049_B. Leu_tRNA_synth_B.
InterProⁱ	IPR001412. aa-tRNA-synth_I_CS. IPR002300. aa-tRNA-synth_Ia. IPR002302. Leu-tRNA-ligase. IPR025709. Leu_tRNA-synth_edit. IPR013155. M/V/L/I-tRNA-synth_anticd-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. IPR009008. Val/Leu/Ile-tRNA-synth_edit. [Graphical view]
PANTHERⁱ	PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfamⁱ	PF08264. Anticodon_1. 1 hit. PF00133. tRNA-synt_1. 3 hits. PF13603. tRNA-synt_1_2. 1 hit. [Graphical view]
PRINTSⁱ	PR00985. TRNASYNTHLEU.
SUPFAMⁱ	SSF47323. SSF47323. 1 hit. SSF50677. SSF50677. 1 hit.
TIGRFAMsⁱ	TIGR00396. leuS_bact. 1 hit.
PROSITEⁱ	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

B9KMH8-1 [UniParc]FASTA Add to Basket

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        10         20         30         40         50
MSRYDPAATE SRWQAAWDAA GVFTARHDPA RPKYYVLEMF PYPSGRIHMG 
        60         70         80         90        100
HVRNYTMGDV VARQKAAAGF SVLHPMGWDA FGMPAENAAM ERGGHPKDWT 
       110        120        130        140        150
YGNIADMRAQ MKPLGLSIDW SREFATCDPE YYGQQQAMFI DMMEAGLVYR 
       160        170        180        190        200
KNAVVNWDPV DMTVLANEQV IDGKGWRSGA PVVRRELTQW FFRISDYAGE 
       210        220        230        240        250
LLEALDTLKD WPEKVRLMQA NWIGQSRGLQ FAFSTAGAPE GFDRLEVYTT 
       260        270        280        290        300
RPDTLMGASF AAISPDHPLA RHLERHDAEV AEFVAECRRV GTSEEALEKA 
       310        320        330        340        350
EKKGFDTGLR VRHPFDTAWE LPVYIANFIL MDYGTGAIFG CPAHDQRDFE 
       360        370        380        390        400
FATKYGLPIR PVFLPEGTEE TALAEAFVPM KSERVHYIRG FAGAEVQSGE 
       410        420        430        440        450
EGVAAAIDFC ESQGVGRGVT NYRLRDWGIS RQRYWGCPIP VIHCETCGVV 
       460        470        480        490        500
PEAKENLPVR LPDDVSFDVP GNPLDRHPTW RDCTCPKCGA KARRETDTMD 
       510        520        530        540        550
TFVDSSWYYA RFTAPRAATP TDAEEADYWM NVDQYIGGIE HAILHLLYSR 
       560        570        580        590        600
FFARAMQKTG HLPAKAIEPF NALFTQGMVT HEIYLTRDAA GRPVYHLPED 
       610        620        630        640        650
VTDGKLADGT PVEIIPSAKM SKSKKNVVDP MNIIRQFGAD TARWFVMSDS 
       660        670        680        690        700
PPERDVEWTA SGAEAASKHL HRVWRLADEI SRADGEANAE DGALDKATAR 
       710        720        730        740        750
AIAEVTQGVE GFAFNKAIAK LYEFTNTLSR SGAGAEAKKR AMRTMAQLMS 
       760        770        780        790        800
PMVPHLAEEV WAMLGGEGLV AQAAWPKADP ALLIDDTVTL PIQVNGKRRG 
       810        820        830        840 
EITVPKEMAA SEVEKLVLAD EAVQRALGGA APKKLIVVPG RIVNVVI

Length:847

Mass (Da):94,035

Last modified:March 24, 2009 - v1

Checksum:ⁱ342919F87D884627

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001150 Genomic DNA. Translation: ACM02069.1.
RefSeqⁱ	YP_002526570.1. NC_011963.1.

Genome annotation databases

EnsemblBacteriaⁱ	ACM02069; ACM02069; RSKD131_2209.
GeneIDⁱ	7358316.
KEGGⁱ	rsk:RSKD131_2209.
PATRICⁱ	23183539. VBIRhoSph125910_3615.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001150 Genomic DNA. Translation: ACM02069.1.
RefSeqⁱ	YP_002526570.1. NC_011963.1.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	557760.RSKD131_2209.

STRINGⁱ

557760.RSKD131_2209.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ACM02069; ACM02069; RSKD131_2209.
GeneIDⁱ	7358316.
KEGGⁱ	rsk:RSKD131_2209.
PATRICⁱ	23183539. VBIRhoSph125910_3615.

Phylogenomic databases

eggNOGⁱ	COG0495.
HOGENOMⁱ	HOG000200747.
KOⁱ	K01869.
OMAⁱ	QSSWYFL.
OrthoDBⁱ	EOG63Z74X.

Enzyme and pathway databases

BioCycⁱ	RSPH557760:GH1P-2236-MONOMER.

BioCycⁱ

RSPH557760:GH1P-2236-MONOMER.

Family and domain databases

Gene3Dⁱ	1.10.730.10. 1 hit. 3.40.50.620. 3 hits. 3.90.740.10. 1 hit.
HAMAPⁱ	MF_00049_B. Leu_tRNA_synth_B.
InterProⁱ	IPR001412. aa-tRNA-synth_I_CS. IPR002300. aa-tRNA-synth_Ia. IPR002302. Leu-tRNA-ligase. IPR025709. Leu_tRNA-synth_edit. IPR013155. M/V/L/I-tRNA-synth_anticd-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. IPR009008. Val/Leu/Ile-tRNA-synth_edit. [Graphical view]
PANTHERⁱ	PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfamⁱ	PF08264. Anticodon_1. 1 hit. PF00133. tRNA-synt_1. 3 hits. PF13603. tRNA-synt_1_2. 1 hit. [Graphical view]
PRINTSⁱ	PR00985. TRNASYNTHLEU.
SUPFAMⁱ	SSF47323. SSF47323. 1 hit. SSF50677. SSF50677. 1 hit.
TIGRFAMsⁱ	TIGR00396. leuS_bact. 1 hit.
PROSITEⁱ	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Publicationsⁱ

"Complete genome sequence of Rhodobacter sphaeroides KD131."
Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K.
J. Bacteriol. 191:1118-1119(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: KD131 / KCTC 12085.

Entry informationⁱ

Entry nameⁱ

SYL_RHOSK

Accessionⁱ

Primary (citable) accession number: B9KMH8

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

Documents

Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries
SIMILARITY comments
Index of protein domains and families

External Data

Dasty 3

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

Proteomes

UniRef

Supporting data

UniParc

Help

B9KMH8 - SYL_RHOSK

UniProt

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Leucine--tRNA ligase

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>Contains the literature citations that are the sources of data used to annotate the entry. Each reference is numbered and contains several subsections allowing a precise description of a given citation.</p><p><a href='../manual/publications_section' target='_top'>More...</a></p>Publicationsi

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

External Data

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Publicationsⁱ

Entry informationⁱ

Miscellaneousⁱ