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UniProtKB - B9KMH8 (SYL_RHOSK)

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Rhodobacter sphaeroides (strain KD131 / KCTC 12085)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei622ATPUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RSKD131_2209
OrganismiRhodobacter sphaeroides (strain KD131 / KCTC 12085)
Taxonomic identifieri557760 [NCBI]
Taxonomic lineageiBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter ›
Proteomesi
  • UP000001597 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001992211 – 847Leucine--tRNA ligaseAdd BLAST847

Structurei

3D structure databases

SMRiB9KMH8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 51"HIGH" regionAdd BLAST11
Motifi619 – 623"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200747.
KOiK01869.
OMAiTFMVLAP.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

B9KMH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRYDPAATE SRWQAAWDAA GVFTARHDPA RPKYYVLEMF PYPSGRIHMG 
        60         70         80         90        100
HVRNYTMGDV VARQKAAAGF SVLHPMGWDA FGMPAENAAM ERGGHPKDWT 
       110        120        130        140        150
YGNIADMRAQ MKPLGLSIDW SREFATCDPE YYGQQQAMFI DMMEAGLVYR 
       160        170        180        190        200
KNAVVNWDPV DMTVLANEQV IDGKGWRSGA PVVRRELTQW FFRISDYAGE 
       210        220        230        240        250
LLEALDTLKD WPEKVRLMQA NWIGQSRGLQ FAFSTAGAPE GFDRLEVYTT 
       260        270        280        290        300
RPDTLMGASF AAISPDHPLA RHLERHDAEV AEFVAECRRV GTSEEALEKA 
       310        320        330        340        350
EKKGFDTGLR VRHPFDTAWE LPVYIANFIL MDYGTGAIFG CPAHDQRDFE 
       360        370        380        390        400
FATKYGLPIR PVFLPEGTEE TALAEAFVPM KSERVHYIRG FAGAEVQSGE 
       410        420        430        440        450
EGVAAAIDFC ESQGVGRGVT NYRLRDWGIS RQRYWGCPIP VIHCETCGVV 
       460        470        480        490        500
PEAKENLPVR LPDDVSFDVP GNPLDRHPTW RDCTCPKCGA KARRETDTMD 
       510        520        530        540        550
TFVDSSWYYA RFTAPRAATP TDAEEADYWM NVDQYIGGIE HAILHLLYSR 
       560        570        580        590        600
FFARAMQKTG HLPAKAIEPF NALFTQGMVT HEIYLTRDAA GRPVYHLPED 
       610        620        630        640        650
VTDGKLADGT PVEIIPSAKM SKSKKNVVDP MNIIRQFGAD TARWFVMSDS 
       660        670        680        690        700
PPERDVEWTA SGAEAASKHL HRVWRLADEI SRADGEANAE DGALDKATAR 
       710        720        730        740        750
AIAEVTQGVE GFAFNKAIAK LYEFTNTLSR SGAGAEAKKR AMRTMAQLMS 
       760        770        780        790        800
PMVPHLAEEV WAMLGGEGLV AQAAWPKADP ALLIDDTVTL PIQVNGKRRG 
       810        820        830        840 
EITVPKEMAA SEVEKLVLAD EAVQRALGGA APKKLIVVPG RIVNVVI
Length:847
Mass (Da):94,035
Last modified:March 24, 2009 - v1
Checksum:i342919F87D884627
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001150 Genomic DNA. Translation: ACM02069.1.
RefSeqiWP_015921266.1. NC_011963.1.

Genome annotation databases

EnsemblBacteriaiACM02069; ACM02069; RSKD131_2209.
KEGGirsk:RSKD131_2209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001150 Genomic DNA. Translation: ACM02069.1.
RefSeqiWP_015921266.1. NC_011963.1.

3D structure databases

SMRiB9KMH8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM02069; ACM02069; RSKD131_2209.
KEGGirsk:RSKD131_2209.

Phylogenomic databases

HOGENOMiHOG000200747.
KOiK01869.
OMAiTFMVLAP.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
PANTHERiPTHR43740. PTHR43740. 1 hit.
PfamiView protein in Pfam
PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSYL_RHOSK
AccessioniPrimary (citable) accession number: B9KMH8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: June 7, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.