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B9KM22

- GCH4_RHOSK

UniProt

B9KM22 - GCH4_RHOSK

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Rhodobacter sphaeroides (strain KD131 / KCTC 12085)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei218 – 2181May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciRSPH557760:GH1P-160-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:RSKD131_0160
    OrganismiRhodobacter sphaeroides (strain KD131 / KCTC 12085)
    Taxonomic identifieri557760 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000001597: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359GTP cyclohydrolase FolE2PRO_1000185156Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557760.RSKD131_0160.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9KM22-1 [UniParc]FASTAAdd to Basket

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    MNILTPVAER LPSREEAEEA LAVLRRWATH TPASDVAALA PEAPALVYPE    50
    LSRSYPRAFT VDEAYKASLP DLQNGPASLI VGAKAVIQHV GISNFRLPIR 100
    YHTRDNGDLQ LETSVTGTVS LEAEKKGINM SRIMRSFYAH AEQAFSFEVI 150
    ERALEDYKRD LESFDARIQM RFSFPVKVPS LRSGLTGWQY YDIALELVDR 200
    GGVRKEIMHL DFVYSSTCPC SLELSEHARR ERGQLATPHS QRSVARISVE 250
    VRQGKCLWFE DLLDLVRSAV PTETQVMVKR EDEQAFAELN AANPIFVEDA 300
    ARSFCQALQS DPRIGDFRVV ASHQESLHSH DAVSVLTEGP TFAAESLDPR 350
    LFSSLYHVG 359
    Length:359
    Mass (Da):40,175
    Last modified:March 24, 2009 - v1
    Checksum:iA32253AD8B9FFB89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001150 Genomic DNA. Translation: ACM00020.1.
    RefSeqiYP_002524521.1. NC_011963.1.

    Genome annotation databases

    EnsemblBacteriaiACM00020; ACM00020; RSKD131_0160.
    GeneIDi7359811.
    KEGGirsk:RSKD131_0160.
    PATRICi23179409. VBIRhoSph125910_1580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001150 Genomic DNA. Translation: ACM00020.1 .
    RefSeqi YP_002524521.1. NC_011963.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557760.RSKD131_0160.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM00020 ; ACM00020 ; RSKD131_0160 .
    GeneIDi 7359811.
    KEGGi rsk:RSKD131_0160.
    PATRICi 23179409. VBIRhoSph125910_1580.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci RSPH557760:GH1P-160-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Rhodobacter sphaeroides KD131."
      Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K.
      J. Bacteriol. 191:1118-1119(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KD131 / KCTC 12085.

    Entry informationi

    Entry nameiGCH4_RHOSK
    AccessioniPrimary (citable) accession number: B9KM22
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3