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B9KLK4

- FTHS_RHOSK

UniProt

B9KLK4 - FTHS_RHOSK

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhodobacter sphaeroides (strain KD131 / KCTC 12085)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSPH557760:GH1P-2045-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:RSKD131_2019
OrganismiRhodobacter sphaeroides (strain KD131 / KCTC 12085)
Taxonomic identifieri557760 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000001597: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_1000185261Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557760.RSKD131_2019.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9KLK4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVQTDIEIA RAARKKPIQE IGAGLGIPAE ALIPYGHDKA KVGQGFIRGL
60 70 80 90 100
EGRPDGKLIL VTAINPTPAG EGKTTTTVGL GDGLNRIGKK AVICIREASL
110 120 130 140 150
GPNFGMKGGA AGGGRAQVVP MEDMNLHFTG DFHAITAAHN LLAAMIDNHI
160 170 180 190 200
YWGNALELDA RRITWRRVMD MNDRALRDTV VNLGGVANGF PRQTGFDITV
210 220 230 240 250
ASEVMAILCL ADDLEDLERR LGRIVVGYRR DKSPVYCRDL KAAGAMAVLL
260 270 280 290 300
KDAMQPNLVQ TIENNPAFVH GGPFANIAHG CNSVIATRTA LKLADYVVTE
310 320 330 340 350
AGFGADLGAE KFFDIKCRLA GLKPSAAVVV ATVRALKMNG GVAREDLGRE
360 370 380 390 400
DVAALRRGCA NLGRHIANVK GFGVPVVVAI NHFTTDTEAE IEAVRAYAAG
410 420 430 440 450
QGAEAFLCRH WAEGSAGIED LAQKVVELAE APSMFAPLYP DDMPLFEKME
460 470 480 490 500
TVARRIYHAH DVIADHVIRD QLRTWEEAGY GALPVCMAKT QYSFTTDAAI
510 520 530 540 550
RGAPEGHSIP IREVRLAAGA GFVVAICGEI RTMPGLPSQP AAELIHLDEE

GRIEGLF
Length:557
Mass (Da):59,588
Last modified:March 24, 2009 - v1
Checksum:i6C8A3F19157AFEF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001150 Genomic DNA. Translation: ACM01879.1.
RefSeqiWP_015921138.1. NC_011963.1.
YP_002526380.1. NC_011963.1.

Genome annotation databases

EnsemblBacteriaiACM01879; ACM01879; RSKD131_2019.
GeneIDi7358607.
KEGGirsk:RSKD131_2019.
PATRICi23183153. VBIRhoSph125910_3423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001150 Genomic DNA. Translation: ACM01879.1 .
RefSeqi WP_015921138.1. NC_011963.1.
YP_002526380.1. NC_011963.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557760.RSKD131_2019.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM01879 ; ACM01879 ; RSKD131_2019 .
GeneIDi 7358607.
KEGGi rsk:RSKD131_2019.
PATRICi 23183153. VBIRhoSph125910_3423.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RSPH557760:GH1P-2045-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rhodobacter sphaeroides KD131."
    Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K.
    J. Bacteriol. 191:1118-1119(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: KD131 / KCTC 12085.

Entry informationi

Entry nameiFTHS_RHOSK
AccessioniPrimary (citable) accession number: B9KLK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3