Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B9KL69

- THIM_RHOSK

UniProt

B9KL69 - THIM_RHOSK

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Rhodobacter sphaeroides (strain KD131 / KCTC 12085)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431Substrate; via amide nitrogenUniRule annotation
    Binding sitei118 – 1181ATPUniRule annotation
    Binding sitei164 – 1641ATPUniRule annotation
    Binding sitei191 – 1911Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSPH557760:GH1P-2032-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:RSKD131_2006
    OrganismiRhodobacter sphaeroides (strain KD131 / KCTC 12085)
    Taxonomic identifieri557760 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000001597: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Hydroxyethylthiazole kinasePRO_1000198128Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557760.RSKD131_2006.

    Structurei

    3D structure databases

    ProteinModelPortaliB9KL69.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiNACTQLA.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9KL69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGCGTYLDT MRREAPLVQC ITNFVAMNVV ANVLLAAGAS PAMVHDAEES    50
    GEFAAIAQAL TINMGTPSPR WVEGMEAAAR GATAAGRPWV LDPVAVGATA 100
    FRRGLGARLL ALKPTVIRGN ASEILALAGA ETRGKGADSA DPVAAAEAAA 150
    QRLAESSGAV VAVTGPVDFV TDGRRGIRCA NGHPLMPRVT ALGCSLTGIV 200
    GAFAAIRPPF EATAAALAFF GLAGEEAAKT ATGPGSFQVA FLDALHALSP 250
    EALDRGARLE AA 262
    Length:262
    Mass (Da):26,475
    Last modified:March 24, 2009 - v1
    Checksum:iA600BB8F64E01896
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001150 Genomic DNA. Translation: ACM01866.1.
    RefSeqiYP_002526367.1. NC_011963.1.

    Genome annotation databases

    EnsemblBacteriaiACM01866; ACM01866; RSKD131_2006.
    GeneIDi7358594.
    KEGGirsk:RSKD131_2006.
    PATRICi23183125. VBIRhoSph125910_3409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001150 Genomic DNA. Translation: ACM01866.1 .
    RefSeqi YP_002526367.1. NC_011963.1.

    3D structure databases

    ProteinModelPortali B9KL69.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557760.RSKD131_2006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM01866 ; ACM01866 ; RSKD131_2006 .
    GeneIDi 7358594.
    KEGGi rsk:RSKD131_2006.
    PATRICi 23183125. VBIRhoSph125910_3409.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi NACTQLA.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci RSPH557760:GH1P-2032-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Rhodobacter sphaeroides KD131."
      Lim S.-K., Kim S.J., Cha S.H., Oh Y.-K., Rhee H.-J., Kim M.-S., Lee J.K.
      J. Bacteriol. 191:1118-1119(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KD131 / KCTC 12085.

    Entry informationi

    Entry nameiTHIM_RHOSK
    AccessioniPrimary (citable) accession number: B9KL69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3