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B9KIY0

- DUT_ANAMF

UniProt

B9KIY0 - DUT_ANAMF

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Protein
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene
dut, AMF_598
Organism
Anaplasma marginale (strain Florida)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801Substrate By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAMAR320483:GIWE-576-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:AMF_598
OrganismiAnaplasma marginale (strain Florida)
Taxonomic identifieri320483 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasma
ProteomesiUP000007307: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 147147Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation
PRO_1000119224Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi320483.AMF_598.

Structurei

3D structure databases

ProteinModelPortaliB9KIY0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 693Substrate binding By similarity
Regioni84 – 863Substrate binding By similarity

Sequence similaritiesi

Belongs to the dUTPase family.

Phylogenomic databases

eggNOGiCOG0756.
HOGENOMiHOG000028966.
KOiK01520.
OrthoDBiEOG689HXK.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00116. dUTPase_bact.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

B9KIY0-1 [UniParc]FASTAAdd to Basket

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MLKVKILRLA SGYGLPLPSY ATPKSAGLDL YAAVDSKLVV HPGGRCAVKT    50
GVALELPDGY EAQIRSRSGL AANFGICVLN APGTIDSDYR GEITVVLSNF 100
GSEDYVISRG DRVAQMVIAP VERVEWEEVN SITATSRGEG GFGSTGT 147
Length:147
Mass (Da):15,464
Last modified:March 24, 2009 - v1
Checksum:i661713874DE1CC9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001079 Genomic DNA. Translation: ACM49442.1.
RefSeqiWP_010270240.1. NC_012026.1.
YP_002563698.1. NC_012026.1.

Genome annotation databases

EnsemblBacteriaiACM49442; ACM49442; AMF_598.
GeneIDi7398040.
KEGGiamf:AMF_598.
PATRICi20945118. VBIAnaMar82315_0692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001079 Genomic DNA. Translation: ACM49442.1 .
RefSeqi WP_010270240.1. NC_012026.1.
YP_002563698.1. NC_012026.1.

3D structure databases

ProteinModelPortali B9KIY0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 320483.AMF_598.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM49442 ; ACM49442 ; AMF_598 .
GeneIDi 7398040.
KEGGi amf:AMF_598.
PATRICi 20945118. VBIAnaMar82315_0692.

Phylogenomic databases

eggNOGi COG0756.
HOGENOMi HOG000028966.
KOi K01520.
OrthoDBi EOG689HXK.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci AMAR320483:GIWE-576-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00116. dUTPase_bact.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Conservation in the face of diversity: multistrain analysis of an intracellular bacterium."
    Dark M.J., Herndon D.R., Kappmeyer L.S., Gonzales M.P., Nordeen E., Palmer G.H., Knowles D.P. Jr., Brayton K.A.
    BMC Genomics 10:16-16(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Florida.

Entry informationi

Entry nameiDUT_ANAMF
AccessioniPrimary (citable) accession number: B9KIY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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