Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malate dehydrogenase

Gene

mdh

Organism
Anaplasma marginale (strain Florida)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38NADUniRule annotation1
Binding sitei87SubstrateUniRule annotation1
Binding sitei93SubstrateUniRule annotation1
Binding sitei100NADUniRule annotation1
Binding sitei125SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Active sitei180Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 18NADUniRule annotation6
Nucleotide bindingi123 – 125NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:AMF_421
OrganismiAnaplasma marginale (strain Florida)
Taxonomic identifieri320483 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasma
Proteomesi
  • UP000007307 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001916381 – 317Malate dehydrogenaseAdd BLAST317

Interactioni

Protein-protein interaction databases

STRINGi320483.AMF_421.

Structurei

3D structure databases

ProteinModelPortaliB9KIH0.
SMRiB9KIH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiICIIANP.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B9KIH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSSRSAKVS LVGAGNIGGA LAHMLGASQV VKELVLVDVA GGMTEGKVLD
60 70 80 90 100
VGQALALLGS DVYITGGSDY AAIEHSDAVV VTAGIPRKEG MSREDLLNTN
110 120 130 140 150
AAVVRNIAEN IAKYSPGALV IVVTNPLDAM VWCMYKYSGL PANRVVGMAG
160 170 180 190 200
VLDSARFSFF LARHMNVSVS SVSAMVLGGH GDLMLPLLRY STVGGVPVES
210 220 230 240 250
LIESGRLNRG DIAAIVERTR KGGEEIVKLL KTGSAYCAPA ASCAHMLESY
260 270 280 290 300
VRDKRSIMPC SAYLDGQYGV RDLFVGVPVI IGEKGVEEVV EFPLTAEEQA
310
VFDQSVELIR GSVSAIS
Length:317
Mass (Da):33,320
Last modified:March 24, 2009 - v1
Checksum:i431DC91533609EC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001079 Genomic DNA. Translation: ACM49282.1.
RefSeqiWP_012658941.1. NZ_AFMS01000024.1.

Genome annotation databases

EnsemblBacteriaiACM49282; ACM49282; AMF_421.
GeneIDi7397962.
KEGGiamf:AMF_421.
PATRICifig|320483.3.peg.493.

Similar proteinsi

Entry informationi

Entry nameiMDH_ANAMF
AccessioniPrimary (citable) accession number: B9KIH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 25, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families