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B9KIH0

- MDH_ANAMF

UniProt

B9KIH0 - MDH_ANAMF

Protein

Malate dehydrogenase

Gene

mdh

Organism
Anaplasma marginale (strain Florida)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381NADUniRule annotation
    Binding sitei87 – 871SubstrateUniRule annotation
    Binding sitei93 – 931SubstrateUniRule annotation
    Binding sitei100 – 1001NADUniRule annotation
    Binding sitei125 – 1251SubstrateUniRule annotation
    Binding sitei156 – 1561SubstrateUniRule annotation
    Active sitei180 – 1801Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 186NADUniRule annotation
    Nucleotide bindingi123 – 1253NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciAMAR320483:GIWE-409-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:AMF_421
    OrganismiAnaplasma marginale (strain Florida)
    Taxonomic identifieri320483 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasma
    ProteomesiUP000007307: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Malate dehydrogenasePRO_1000191638Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi320483.AMF_421.

    Structurei

    3D structure databases

    ProteinModelPortaliB9KIH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213794.
    KOiK00024.
    OrthoDBiEOG6091FG.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9KIH0-1 [UniParc]FASTAAdd to Basket

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    MRSSRSAKVS LVGAGNIGGA LAHMLGASQV VKELVLVDVA GGMTEGKVLD    50
    VGQALALLGS DVYITGGSDY AAIEHSDAVV VTAGIPRKEG MSREDLLNTN 100
    AAVVRNIAEN IAKYSPGALV IVVTNPLDAM VWCMYKYSGL PANRVVGMAG 150
    VLDSARFSFF LARHMNVSVS SVSAMVLGGH GDLMLPLLRY STVGGVPVES 200
    LIESGRLNRG DIAAIVERTR KGGEEIVKLL KTGSAYCAPA ASCAHMLESY 250
    VRDKRSIMPC SAYLDGQYGV RDLFVGVPVI IGEKGVEEVV EFPLTAEEQA 300
    VFDQSVELIR GSVSAIS 317
    Length:317
    Mass (Da):33,320
    Last modified:March 24, 2009 - v1
    Checksum:i431DC91533609EC4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001079 Genomic DNA. Translation: ACM49282.1.
    RefSeqiYP_002563538.1. NC_012026.1.

    Genome annotation databases

    EnsemblBacteriaiACM49282; ACM49282; AMF_421.
    GeneIDi7397962.
    KEGGiamf:AMF_421.
    PATRICi20944710. VBIAnaMar82315_0493.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001079 Genomic DNA. Translation: ACM49282.1 .
    RefSeqi YP_002563538.1. NC_012026.1.

    3D structure databases

    ProteinModelPortali B9KIH0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 320483.AMF_421.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM49282 ; ACM49282 ; AMF_421 .
    GeneIDi 7397962.
    KEGGi amf:AMF_421.
    PATRICi 20944710. VBIAnaMar82315_0493.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213794.
    KOi K00024.
    OrthoDBi EOG6091FG.

    Enzyme and pathway databases

    BioCyci AMAR320483:GIWE-409-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Conservation in the face of diversity: multistrain analysis of an intracellular bacterium."
      Dark M.J., Herndon D.R., Kappmeyer L.S., Gonzales M.P., Nordeen E., Palmer G.H., Knowles D.P. Jr., Brayton K.A.
      BMC Genomics 10:16-16(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Florida.

    Entry informationi

    Entry nameiMDH_ANAMF
    AccessioniPrimary (citable) accession number: B9KIH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3