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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Anaplasma marginale (strain Florida)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:AMF_1006
OrganismiAnaplasma marginale (strain Florida)
Taxonomic identifieri320483 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeAnaplasma
Proteomesi
  • UP000007307 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002006561 – 397Exodeoxyribonuclease 7 large subunitAdd BLAST397

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Protein-protein interaction databases

STRINGi320483.AMF_1006.

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
KOiK03601.
OMAiHEIDWVI.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

B9KHB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRSCSTEM IPEFTVTEIT DLVRQVMHDT FYCIKIRGEI SGLSRPSSGH
60 70 80 90 100
VYLSLKDDNS VISAVCWHGT RLDVQFENGL EVICTGHIST YQSRYQLVIE
110 120 130 140 150
GMVLAGQGKL AAMLEERRKK LEKEGLFDQA RKKPLPLLPL KIGVITSPTG
160 170 180 190 200
AVIRDILNRV KHRFPSHIIV WPVQVQGSQA SAMVVQAILG FNNLEEPPDV
210 220 230 240 250
IIVARGGGSI EDLWPFNDEE LARTAAASKI PIVSAIGHET DFTIIDYAAD
260 270 280 290 300
VRAPTPTAAV EIVLPERQQL VSDIAHKLSK IRSAVRNVLG AKEHRLLQLY
310 320 330 340 350
GVLTETKHKI SEVGRSALAH QEKIEFLFKV ALLKKQQYLD NLIGRIDRYN
360 370 380 390
KEHIISVGYA VIYDNTGQHV SSANAVAPDD TIVIEWKDGK RRAAILT
Length:397
Mass (Da):44,109
Last modified:March 24, 2009 - v1
Checksum:i8D1E13A4E52AC2C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001079 Genomic DNA. Translation: ACM49822.1.

Genome annotation databases

EnsemblBacteriaiACM49822; ACM49822; AMF_1006.
KEGGiamf:AMF_1006.
PATRICi20946052. VBIAnaMar82315_1149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001079 Genomic DNA. Translation: ACM49822.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi320483.AMF_1006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM49822; ACM49822; AMF_1006.
KEGGiamf:AMF_1006.
PATRICi20946052. VBIAnaMar82315_1149.

Phylogenomic databases

eggNOGiENOG4105DVS. Bacteria.
COG1570. LUCA.
HOGENOMiHOG000229265.
KOiK03601.
OMAiHEIDWVI.
OrthoDBiPOG091H02EK.

Family and domain databases

CDDicd04489. ExoVII_LU_OBF. 1 hit.
HAMAPiMF_00378. Exonuc_7_L. 1 hit.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEX7L_ANAMF
AccessioniPrimary (citable) accession number: B9KHB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: November 2, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.