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B9KG97

- ASSY_CAMLR

UniProt

B9KG97 - ASSY_CAMLR

Protein

Argininosuccinate synthase

Gene

argG

Organism
Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei91 – 911CitrullineUniRule annotation
    Binding sitei96 – 961CitrullineUniRule annotation
    Binding sitei121 – 1211ATP; via amide nitrogenUniRule annotation
    Binding sitei123 – 1231AspartateUniRule annotation
    Binding sitei127 – 1271AspartateUniRule annotation
    Binding sitei127 – 1271CitrullineUniRule annotation
    Binding sitei128 – 1281AspartateUniRule annotation
    Binding sitei131 – 1311CitrullineUniRule annotation
    Binding sitei181 – 1811CitrullineUniRule annotation
    Binding sitei190 – 1901CitrullineUniRule annotation
    Binding sitei266 – 2661CitrullineUniRule annotation
    Binding sitei278 – 2781CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 199ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCLAR306263:GH7X-753-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Cla_0754
    OrganismiCampylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
    Taxonomic identifieri306263 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000007727: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Argininosuccinate synthasePRO_1000191887Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi306263.Cla_0754.

    Structurei

    3D structure databases

    ProteinModelPortaliB9KG97.
    SMRiB9KG97. Positions 7-396.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9KG97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKDIKKVVL AYSGGLDTSI ILKWLQDEYK SEVVTFTADI GQGEELEPAR    50
    KKALSLGVKE ENIFIKDLKD EFVKDYVFAM FRANAIYEGE YLLGTSIARP 100
    LIAKALVEIA NKTNADAISH GATGKGNDQV RFELGALALN PNLAIIAPWR 150
    EWDLNSREKL LAYAQKHGID IVKKADKSPY SMDANLLHIS YEGLVLEDPA 200
    AKPEADMWRW VRDLKQTPNE SEVIELEFSK GDLCAINGEK MSPAQLLAKL 250
    NELGAKHGIG RLDIVENRYV GMKSRGCYET PGGSILLKAH RAIESITLDR 300
    EAAHLKDELM PKYASLIYNG YWFSPERLML QALIDESQKH VNGKVKLELY 350
    KGNVMVIGRE SANDSLFSEA YCTFEEDSVY DQKDAAGFIK LNALRFIIAG 400
    KNGRKF 406
    Length:406
    Mass (Da):45,457
    Last modified:March 24, 2009 - v1
    Checksum:i654F8A1C2B6A40FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000932 Genomic DNA. Translation: ACM64082.1.
    RefSeqiYP_002575333.1. NC_012039.1.

    Genome annotation databases

    EnsemblBacteriaiACM64082; ACM64082; Cla_0754.
    GeneIDi7410088.
    KEGGicla:Cla_0754.
    PATRICi20061977. VBICamLar15090_0734.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000932 Genomic DNA. Translation: ACM64082.1 .
    RefSeqi YP_002575333.1. NC_012039.1.

    3D structure databases

    ProteinModelPortali B9KG97.
    SMRi B9KG97. Positions 7-396.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 306263.Cla_0754.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM64082 ; ACM64082 ; Cla_0754 .
    GeneIDi 7410088.
    KEGGi cla:Cla_0754.
    PATRICi 20061977. VBICamLar15090_0734.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci CLAR306263:GH7X-753-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence and analysis of the human pathogen Campylobacter lari."
      Miller W.G., Wang G., Binnewies T.T., Parker C.T.
      Foodborne Pathog. Dis. 5:371-386(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RM2100 / D67 / ATCC BAA-1060.

    Entry informationi

    Entry nameiASSY_CAMLR
    AccessioniPrimary (citable) accession number: B9KG97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3