B9KFZ2 (KAD_CAMLR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

Name:	adk
Ordered Locus Names:	Cla_0648

Organism

Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060) [Complete proteome] [HAMAP]

Taxonomic identifier

306263 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP MF_00235
Subunit structure	Monomer By similarity. HAMAP MF_00235
Subcellular location	Cytoplasm By similarity HAMAP MF_00235.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP MF_00235
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 190	190	Adenylate kinase HAMAP MF_00235		PRO_1000191130
Regions
	Nucleotide binding	9 – 17	9	ATP By similarity
	Nucleotide binding	34 – 62	29	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9KFZ2 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 68A8AEB31EBB5939	FASTA	190	20,964
	10 20 30 40 50 60 MKQLFLIIGA PGSGKTTDAS IIANDNANIT HYSTGDLLRA EVASGSELGK TIDSFISKGN 70 80 90 100 110 120 LVPLEVVVNT IITALKNAPT NTILIDGYPR SVEQMLEFDK VLKNQSEVNL KGVIEVKVSE 130 140 150 160 170 180 EVARERVLGR ARGADDNEEV FNNRMKVYLE PLNEITNFYA KENIHHIING ERSIEAIVAD 190 MKNLINELLK

References

[1]

"The complete genome sequence and analysis of the human pathogen Campylobacter lari." Miller W.G., Wang G., Binnewies T.T., Parker C.T. Foodborne Pathog. Dis. 5:371-386(2008) [PubMed: 18713059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RM2100 / D67 / ATCC BAA-1060.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000932 Genomic DNA. Translation: ACM63977.1.
RefSeq	YP_002575228.1. NC_012039.1.
3D structure databases
ProteinModelPortal	B9KFZ2.
ModBase	Search...
Protein-protein interaction databases
STRING	B9KFZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7410714.
GenomeReviews	Gene locus Cla_0648 in contig CP000932_GR.
KEGG	cla:Cla_0648.
PATRIC	20061763. VBICamLar15090_0628.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EMQKYIL.
ProtClustDB	PRK00279.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk. [Tree]
InterPro	IPR000850. Adenylate_kin. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD_CAMLR

Accession

Primary (citable) accession number: B9KFZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program