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B9KFP1

- PYRF_CAMLR

UniProt

B9KFP1 - PYRF_CAMLR

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 81SubstrateUniRule annotation
    Binding sitei30 – 301SubstrateUniRule annotation
    Active sitei60 – 601Proton donorUniRule annotation
    Binding sitei117 – 1171SubstrateUniRule annotation
    Binding sitei177 – 1771SubstrateUniRule annotation
    Binding sitei186 – 1861SubstrateUniRule annotation
    Binding sitei206 – 2061Substrate; via amide nitrogenUniRule annotation
    Binding sitei207 – 2071SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciCLAR306263:GH7X-541-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:Cla_0542
    OrganismiCampylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
    Taxonomic identifieri306263 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000007727: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Orotidine 5'-phosphate decarboxylasePRO_1000164564Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi306263.Cla_0542.

    Structurei

    3D structure databases

    ProteinModelPortaliB9KFP1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni58 – 6710Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226071.
    KOiK01591.
    OMAiHAKEPRE.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9KFP1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLCVAFDVA SYDECINLAK ELKGLDLWVK IGLRSYLRDG VKLLEAIKKV    50
    DNFKIFLDLK LYDIPNTMAD ACEELAKLDV NMFNIHASAG KSAMCMIMER 100
    LNALSKRPLV LAVSALTSFD EQEFFSVYKQ DIKQAVKDFS KISYESGLDG 150
    MVCSVYESLL IKENTSANFI TLTPGIRPFK ENSDDQKRVA DIQCAKDNLS 200
    DFIVVGRPIY KAKEPRRICE NILEHLK 227
    Length:227
    Mass (Da):25,708
    Last modified:March 24, 2009 - v1
    Checksum:i662681AE53A49D4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000932 Genomic DNA. Translation: ACM63876.1.
    RefSeqiWP_012661259.1. NC_012039.1.
    YP_002575127.1. NC_012039.1.

    Genome annotation databases

    EnsemblBacteriaiACM63876; ACM63876; Cla_0542.
    GeneIDi7411102.
    KEGGicla:Cla_0542.
    PATRICi20061547. VBICamLar15090_0525.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000932 Genomic DNA. Translation: ACM63876.1 .
    RefSeqi WP_012661259.1. NC_012039.1.
    YP_002575127.1. NC_012039.1.

    3D structure databases

    ProteinModelPortali B9KFP1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 306263.Cla_0542.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM63876 ; ACM63876 ; Cla_0542 .
    GeneIDi 7411102.
    KEGGi cla:Cla_0542.
    PATRICi 20061547. VBICamLar15090_0525.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226071.
    KOi K01591.
    OMAi HAKEPRE.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci CLAR306263:GH7X-541-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence and analysis of the human pathogen Campylobacter lari."
      Miller W.G., Wang G., Binnewies T.T., Parker C.T.
      Foodborne Pathog. Dis. 5:371-386(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RM2100 / D67 / ATCC BAA-1060.

    Entry informationi

    Entry nameiPYRF_CAMLR
    AccessioniPrimary (citable) accession number: B9KFP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3