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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei71Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciCLAR306263:G1GB2-126-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:Cla_0126
OrganismiCampylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Taxonomic identifieri306263 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
Proteomesi
  • UP000007727 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001997741 – 229Uracil-DNA glycosylaseAdd BLAST229

Proteomic databases

PRIDEiB9KEK7

Interactioni

Protein-protein interaction databases

STRINGi306263.Cla_0126

Structurei

3D structure databases

ProteinModelPortaliB9KEK7
SMRiB9KEK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S Bacteria
COG0692 LUCA
HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF
OrthoDBiPOG091H03VL

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

B9KEK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDICLEKIKI EQTWKEFLKD EFLKPYFLEI KTHYINALNE GKTIYPPANL
60 70 80 90 100
IFNAFNLAPL QDLKIILLGQ DPYHNPHQAM GLSFSVPMGV KIPPSLLNIY
110 120 130 140 150
KELQNDLNIP MAKHGDLSKW AKQGVLLLNS ILSVEANKPA SHAHFGWQKF
160 170 180 190 200
TDAVISKLSD EKEGLVFLLW GNYAKNKKVL INPQKHFILE AAHPSPLARN
210 220
AFLGCKHFSK SNEILLKLGK SPIDWNLNL
Length:229
Mass (Da):26,020
Last modified:March 24, 2009 - v1
Checksum:iD9F609D093DE0CC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000932 Genomic DNA Translation: ACM63492.1
RefSeqiWP_012660877.1, NC_012039.1

Genome annotation databases

EnsemblBacteriaiACM63492; ACM63492; Cla_0126
GeneIDi7411358
KEGGicla:Cla_0126
PATRICifig|306263.5.peg.126

Similar proteinsi

Entry informationi

Entry nameiUNG_CAMLR
AccessioniPrimary (citable) accession number: B9KEK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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