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B9KED6

- DAPF_CAMLR

UniProt

B9KED6 - DAPF_CAMLR

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Protein
Diaminopimelate epimerase
Gene
dapF, Cla_0054
Organism
Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Substrate By similarity
Binding sitei42 – 421Substrate By similarity
Binding sitei60 – 601Substrate By similarity
Active sitei69 – 691Proton donor/acceptor By similarity
Sitei138 – 1381Important for catalytic activity By similarity
Binding sitei164 – 1641Substrate By similarity
Sitei182 – 1821Important for catalytic activity By similarity
Active sitei192 – 1921Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciCLAR306263:GH7X-54-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:Cla_0054
OrganismiCampylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Taxonomic identifieri306263 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000007727: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Diaminopimelate epimeraseUniRule annotation
PRO_1000124405Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi69 ↔ 192UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi306263.Cla_0054.

Structurei

3D structure databases

ProteinModelPortaliB9KED6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 713Substrate binding By similarity
Regioni182 – 1832Substrate binding By similarity
Regioni193 – 1942Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiINTGSPH.
OrthoDBiEOG6ND0M5.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9KED6-1 [UniParc]FASTAAdd to Basket

« Hide

MKFYKYCASG NDFVIFADSE KKDRSELAKI LCNRYEGIGA DGLIVIVPHD    50
RYDFEWEFYN CDGSKANMCG NGSRAAAHFA HHHLKKSQYL NFLTGAGLIK 100
SFVDDDIVEI KLSGIKDIKE AFEYKDRIWQ GCNTGVPHIV TFVDDLSEFD 150
INLCKEVRKK YNANVNFAKV EDDEFIRVRT YERGVEDETL ACGTGMGACF 200
YLAYLNQKVK DDILIKPKSN ESLYFRLEEE QIFFRGKVKC CFEADYNFT 249
Length:249
Mass (Da):28,688
Last modified:March 24, 2009 - v1
Checksum:i3DD123F7A4E7280F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000932 Genomic DNA. Translation: ACM63421.1.
RefSeqiYP_002574672.1. NC_012039.1.

Genome annotation databases

EnsemblBacteriaiACM63421; ACM63421; Cla_0054.
GeneIDi7410615.
KEGGicla:Cla_0054.
PATRICi20060549. VBICamLar15090_0054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000932 Genomic DNA. Translation: ACM63421.1 .
RefSeqi YP_002574672.1. NC_012039.1.

3D structure databases

ProteinModelPortali B9KED6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 306263.Cla_0054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM63421 ; ACM63421 ; Cla_0054 .
GeneIDi 7410615.
KEGGi cla:Cla_0054.
PATRICi 20060549. VBICamLar15090_0054.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi INTGSPH.
OrthoDBi EOG6ND0M5.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci CLAR306263:GH7X-54-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence and analysis of the human pathogen Campylobacter lari."
    Miller W.G., Wang G., Binnewies T.T., Parker C.T.
    Foodborne Pathog. Dis. 5:371-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM2100 / D67 / ATCC BAA-1060.

Entry informationi

Entry nameiDAPF_CAMLR
AccessioniPrimary (citable) accession number: B9KED6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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