B9KE25 (PYRE_CAMLR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Orotate phosphoribosyltransferase
Short name=OPRT
Short name=OPRTase
EC=2.4.2.10

Gene names

Name:	pyrE
Ordered Locus Names:	Cla_1509

Organism

Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060) [Complete proteome] [HAMAP]

Taxonomic identifier

306263 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208
Catalytic activity	Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208
Cofactor	Magnesium By similarity. HAMAP MF_01208
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208
Subunit structure	Homodimer By similarity. HAMAP MF_01208
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Magnesium
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	orotate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	Orotate phosphoribosyltransferase HAMAP MF_01208		PRO_1000164676
Regions
	Region	113 – 121	9	5-phosphoribose 1-diphosphate binding By similarity
Sites
	Binding site	117	1	Orotate By similarity
	Binding site	145	1	Orotate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9KE25 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 2520F84918174E90	FASTA	202	22,079
	10 20 30 40 50 60 MNLEQIYKDC GAYLQGHFLL SSGKHSEFYL QSAKVLEDPK LAGKLCDELA KIIASYDIKF 70 80 90 100 110 120 DSICSPALGG ILAGYELARA CNKRFIFTER VEGVMNLRRG FEVKKGEKFI VCEDIITTGG 130 140 150 160 170 180 SALESAKIIE SLGGEVVGFA ALANRGFCAV KNLNNPRKEN AKLPENLPLF ALGNFEFEIY 190 200 EANVCPLCEK GTKAIKPGSR GN

References

[1]

"The complete genome sequence and analysis of the human pathogen Campylobacter lari." Miller W.G., Wang G., Binnewies T.T., Parker C.T. Foodborne Pathog. Dis. 5:371-386(2008) [PubMed: 18713059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RM2100 / D67 / ATCC BAA-1060.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000932 Genomic DNA. Translation: ACM64813.1.
RefSeq	YP_002576065.1. NC_012039.1.
3D structure databases
ProteinModelPortal	B9KE25.
ModBase	Search...
Protein-protein interaction databases
STRING	B9KE25.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7411255.
GenomeReviews	Gene locus Cla_1509 in contig CP000932_GR.
KEGG	cla:Cla_1509.
PATRIC	20063515. VBICamLar15090_1489.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FYLQSAK.
ProtClustDB	PRK00455.
Family and domain databases
HAMAP	MF_01208. PyrE. [Tree]
InterPro	IPR023031. Orotate_PribosylTferase. IPR006273. Orotate_PRibTrfase_thermus-typ. IPR000836. PRibTrfase. [Graphical view]
KO	K00762.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
TIGRFAMs	TIGR01367. PyrE_Therm. 1 hit.
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRE_CAMLR

Accession

Primary (citable) accession number: B9KE25

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program