Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B9KDZ8 (GCH1_CAMLR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:Cla_1481
OrganismCampylobacter lari (strain RM2100 / D67 / ATCC BAA-1060) [Complete proteome] [HAMAP]
Taxonomic identifier306263 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity. HAMAP-Rule MF_00223

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000124912

Sites

Metal binding751Zinc By similarity
Metal binding781Zinc By similarity
Metal binding1461Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
B9KDZ8 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: D51A14B027E1E51E

FASTA19021,775
        10         20         30         40         50         60 
MQEKFEQSVK NMLEIIGENP QREGLLKTPT RVFKAFEFLN SGYKQDPKQI LNDALFESSN 

        70         80         90        100        110        120 
NEMVLVRDIE FYSLCEHHLL PFFGRVHVAY IPDKKVVGLS KIPRLVEVFA RRLQIQEQLT 

       130        140        150        160        170        180 
EQIAEALMEH VGAKGVGVVI EARHMCVEMR GVQKANSTTS TSALRGSFLK SEKTRKEFFT 

       190 
LINSAKQVRF 

« Hide

References

[1]"The complete genome sequence and analysis of the human pathogen Campylobacter lari."
Miller W.G., Wang G., Binnewies T.T., Parker C.T.
Foodborne Pathog. Dis. 5:371-386(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RM2100 / D67 / ATCC BAA-1060.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000932 Genomic DNA. Translation: ACM64786.1.
RefSeqYP_002576038.1. NC_012039.1.

3D structure databases

ProteinModelPortalB9KDZ8.
SMRB9KDZ8. Positions 2-183.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING306263.Cla_1481.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM64786; ACM64786; Cla_1481.
GeneID7411227.
KEGGcla:Cla_1481.
PATRIC20063459. VBICamLar15090_1462.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMARKPGAVT.
OrthoDBEOG6XHC8G.
ProtClustDBPRK09347.

Enzyme and pathway databases

BioCycCLAR306263:GH7X-1479-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_CAMLR
AccessionPrimary (citable) accession number: B9KDZ8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways