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B9KD25 (B9KD25_CAMLR) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length858 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. HAMAP-Rule MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP-Rule MF_01897 SAAS SAAS005743

Subunit structure

Heterotetramer, composed of two GyrA and two GyrB chains. Within the heterotetramer, GyrA contains the active site tyrosine that forms a covalent intermediate with the DNA, while GyrB contributes the cofactor binding sites and catalyzes ATP hydrolysis By similarity. HAMAP-Rule MF_01897

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP-Rule MF_01897

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1251O-(5'-phospho-DNA)-tyrosine intermediate By similarity HAMAP-Rule MF_01897

Sequences

Sequence LengthMass (Da)Tools
B9KD25 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 0F04E3914269E959

FASTA85896,239
        10         20         30         40         50         60 
MENIFTKDSD IENIDIESSI KSSYLDYSMS VIIGRALPDA RDGLKPVHRR ILYAMNDLGV 

        70         80         90        100        110        120 
GSRSAYKKSA RIVGDVIGKY HPHGDVAVYD ALVRMAQDFS MRYPSVDGQG NFGSIDGDGA 

       130        140        150        160        170        180 
AAMRYTEARM TILAEELLRD IDKDTVDFVP NYDDSMSEPD VLPARVPNLL LNGSSGIAVG 

       190        200        210        220        230        240 
MATNIPPHSL NELIDGLLYL IDNKESSLEE IMQFIKGPDF PTGGIIYGKK GIIEAYRTGR 

       250        260        270        280        290        300 
GRVKVRAKTH IEKRANKDII VIDELPYQTN KARLIEQIAD LAKEKQIEGI AEVRDESDRE 

       310        320        330        340        350        360 
GIRVVIELKR DAMSEIVLNN LFKSTTMEST FGVIMLAIHN KEPKVFSLIE LLKLFLNHRK 

       370        380        390        400        410        420 
TVIIRRTIFE LQKARARAHI LEGLKIALDN IDEVIALIKN SPDNPTAKNL LMQKFGLSEL 

       430        440        450        460        470        480 
QSNAILDMKL GRLTGLEREK IDNELKELLA EIERLDEILK SEALLENLIK DELKEIRSKF 

       490        500        510        520        530        540 
DVPRITQIED DYDDIDIEDL IPNENMVVTI THRGYIKRVP SKQYEKQKRG GKGKVAVTTY 

       550        560        570        580        590        600 
DDDFIENFFT ANTHDTLMFV TDRGQLYWLK VYKIPEGSRT AKGKAVVNLI NLQADEKIMA 

       610        620        630        640        650        660 
IIPTTDFDES KSLCFFTKNG IVKRTNLSEY QNIRSVGVKA INLDENDELV TAIIVARDEN 

       670        680        690        700        710        720 
EMSNQALEDE ENLENEVLEN NEELENVAVG KMLFAVTKKG MCIKFPLAKV REIGRVSRGV 

       730        740        750        760        770        780 
TAIKFKEKND ELVGAVVIEN DAQEILSVSA KGIGKRTDAG EYRLQSRGGK GVICMKLNAK 

       790        800        810        820        830        840 
TKDLISVVIV DESMDLMALT TSGKMIRVDM QSIRKAGRNT SGVIVVNVEN DEVVSIAKCP 

       850 
KEEDEELDTE TNIDLNLE

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References

[1]"The complete genome sequence and analysis of the human pathogen Campylobacter lari."
Miller W.G., Wang G., Binnewies T.T., Parker C.T.
Foodborne Pathog. Dis. 5:371-386(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RM2100 / D67 / ATCC BAA-1060.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000932 Genomic DNA. Translation: ACM64464.1.
RefSeqYP_002575715.1. NC_012039.1.

3D structure databases

ProteinModelPortalB9KD25.
SMRB9KD25. Positions 33-488.
ModBaseSearch...

Protein-protein interaction databases

STRING306263.Cla_1142.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM64464; ACM64464; Cla_1142.
GeneID7410876.
KEGGcla:Cla_1142.
PATRIC20062767. VBICamLar15090_1128.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0188.
HOGENOMHOG000076278.
KOK02469.
OMAIAQEDVV.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycCLAR306263:GH7X-1140-MONOMER.

Family and domain databases

Gene3D3.30.1360.40. 1 hit.
3.90.199.10. 2 hits.
HAMAPMF_01897. GyrA.
InterProIPR024946. Arg_repress_C-like.
IPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013760. Topo_IIA_like_dom.
[Graphical view]
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. gyrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB9KD25_CAMLR
AccessionPrimary (citable) accession number: B9KD25
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 29, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info