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B9KCS8

- SYL_CAMLR

UniProt

B9KCS8 - SYL_CAMLR

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Protein
Leucine--tRNA ligase
Gene
leuS, Cla_1045
Organism
Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei582 – 5821ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCLAR306263:GH7X-1043-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Cla_1045
OrganismiCampylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Taxonomic identifieri306263 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000007727: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 809809Leucine--tRNA ligaseUniRule annotation
PRO_1000199186Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi306263.Cla_1045.

Structurei

3D structure databases

ProteinModelPortaliB9KCS8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionUniRule annotation
Add
BLAST
Motifi579 – 5835"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9KCS8-1 [UniParc]FASTAAdd to Basket

« Hide

MAYEAGKIEK KWQKIWQEKE YFEPKDDFSL PKKYILSMFP YPSGRIHMGH    50
VRNYSIGDAM ARYYRKKGFN VLHPIGFDSF GMPAENAAIK HGIHPKKWTY 100
ENIDYMQNEL ASLGFSFSKK RMLATSDPLY TKFEQEFFIK MYEKGLIYTK 150
EAEVNWCEND KTVLANEQVE DGKCWRCGHE VIRKKMPGYY VKITAYADEL 200
LQDLKKLEGK WPSQVLTMQE NWIGKSTGLS FDFDIEENNK ISAKKINVFT 250
TRAETIYGVS YIALAPDHEI VNELIDKKLL DQDVIAKIQN IQNQTPRQRQ 300
AAPKEGYFLN LYVIHPLSKE KIPLWVANFV LSDYGSGAVM SVPAHDERDY 350
EFAKTYNLAI KKVIYKDEND AQCYTLKEGV LTSSGEFDQL ECNDAREKIS 400
LKIESLGIGK KVTNFKIRDW GVSRQRYWGA PIPMIKCDSC GIVPQKIENL 450
PITLPEDVVI NGEGNPLDKH ETWKECICPK CGKKAQKESD TLDTFFESSW 500
YFARFASDDK TWQEKAVDEK SVNYWMNVDE YIGGIEHAIL HLLYARFFQK 550
ALRDLGYLKD DEPFNRLLTQ GMVTKDGAKM SKSKGNVVDP DYIIEKYGAD 600
SARLFILFAA PPAKELEWND SALEGAFKFI NRLYEKAMSL ECGKLQEIDH 650
QSLNKEEKYA RLKVYEALKK SFEVYEESFA FNTLIAACME ALNALNAINH 700
KEVSKEAFYI ILNILEPIIP HVCFELSEYL FKCENFKVLK IKDEVFIKDS 750
FNIAISVNGK KRAQIEINSE AKEDEILALA KENVAKWLEG KTIVKEIYID 800
KKLVNLVVK 809
Length:809
Mass (Da):93,357
Last modified:March 24, 2009 - v1
Checksum:iAE1DA80F77FDCD12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000932 Genomic DNA. Translation: ACM64367.1.
RefSeqiYP_002575618.1. NC_012039.1.

Genome annotation databases

EnsemblBacteriaiACM64367; ACM64367; Cla_1045.
GeneIDi7410779.
KEGGicla:Cla_1045.
PATRICi20062569. VBICamLar15090_1029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000932 Genomic DNA. Translation: ACM64367.1 .
RefSeqi YP_002575618.1. NC_012039.1.

3D structure databases

ProteinModelPortali B9KCS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 306263.Cla_1045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM64367 ; ACM64367 ; Cla_1045 .
GeneIDi 7410779.
KEGGi cla:Cla_1045.
PATRICi 20062569. VBICamLar15090_1029.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CLAR306263:GH7X-1043-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence and analysis of the human pathogen Campylobacter lari."
    Miller W.G., Wang G., Binnewies T.T., Parker C.T.
    Foodborne Pathog. Dis. 5:371-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM2100 / D67 / ATCC BAA-1060.

Entry informationi

Entry nameiSYL_CAMLR
AccessioniPrimary (citable) accession number: B9KCS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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