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B9KCS8

- SYL_CAMLR

UniProt

B9KCS8 - SYL_CAMLR

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei582 – 5821ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCLAR306263:GH7X-1043-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Cla_1045
OrganismiCampylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Taxonomic identifieri306263 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000007727: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 809809Leucine--tRNA ligasePRO_1000199186Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi306263.Cla_1045.

Structurei

3D structure databases

ProteinModelPortaliB9KCS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionAdd
BLAST
Motifi579 – 5835"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9KCS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYEAGKIEK KWQKIWQEKE YFEPKDDFSL PKKYILSMFP YPSGRIHMGH
60 70 80 90 100
VRNYSIGDAM ARYYRKKGFN VLHPIGFDSF GMPAENAAIK HGIHPKKWTY
110 120 130 140 150
ENIDYMQNEL ASLGFSFSKK RMLATSDPLY TKFEQEFFIK MYEKGLIYTK
160 170 180 190 200
EAEVNWCEND KTVLANEQVE DGKCWRCGHE VIRKKMPGYY VKITAYADEL
210 220 230 240 250
LQDLKKLEGK WPSQVLTMQE NWIGKSTGLS FDFDIEENNK ISAKKINVFT
260 270 280 290 300
TRAETIYGVS YIALAPDHEI VNELIDKKLL DQDVIAKIQN IQNQTPRQRQ
310 320 330 340 350
AAPKEGYFLN LYVIHPLSKE KIPLWVANFV LSDYGSGAVM SVPAHDERDY
360 370 380 390 400
EFAKTYNLAI KKVIYKDEND AQCYTLKEGV LTSSGEFDQL ECNDAREKIS
410 420 430 440 450
LKIESLGIGK KVTNFKIRDW GVSRQRYWGA PIPMIKCDSC GIVPQKIENL
460 470 480 490 500
PITLPEDVVI NGEGNPLDKH ETWKECICPK CGKKAQKESD TLDTFFESSW
510 520 530 540 550
YFARFASDDK TWQEKAVDEK SVNYWMNVDE YIGGIEHAIL HLLYARFFQK
560 570 580 590 600
ALRDLGYLKD DEPFNRLLTQ GMVTKDGAKM SKSKGNVVDP DYIIEKYGAD
610 620 630 640 650
SARLFILFAA PPAKELEWND SALEGAFKFI NRLYEKAMSL ECGKLQEIDH
660 670 680 690 700
QSLNKEEKYA RLKVYEALKK SFEVYEESFA FNTLIAACME ALNALNAINH
710 720 730 740 750
KEVSKEAFYI ILNILEPIIP HVCFELSEYL FKCENFKVLK IKDEVFIKDS
760 770 780 790 800
FNIAISVNGK KRAQIEINSE AKEDEILALA KENVAKWLEG KTIVKEIYID

KKLVNLVVK
Length:809
Mass (Da):93,357
Last modified:March 24, 2009 - v1
Checksum:iAE1DA80F77FDCD12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000932 Genomic DNA. Translation: ACM64367.1.
RefSeqiWP_012661750.1. NC_012039.1.
YP_002575618.1. NC_012039.1.

Genome annotation databases

EnsemblBacteriaiACM64367; ACM64367; Cla_1045.
GeneIDi7410779.
KEGGicla:Cla_1045.
PATRICi20062569. VBICamLar15090_1029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000932 Genomic DNA. Translation: ACM64367.1 .
RefSeqi WP_012661750.1. NC_012039.1.
YP_002575618.1. NC_012039.1.

3D structure databases

ProteinModelPortali B9KCS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 306263.Cla_1045.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM64367 ; ACM64367 ; Cla_1045 .
GeneIDi 7410779.
KEGGi cla:Cla_1045.
PATRICi 20062569. VBICamLar15090_1029.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CLAR306263:GH7X-1043-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence and analysis of the human pathogen Campylobacter lari."
    Miller W.G., Wang G., Binnewies T.T., Parker C.T.
    Foodborne Pathog. Dis. 5:371-386(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM2100 / D67 / ATCC BAA-1060.

Entry informationi

Entry nameiSYL_CAMLR
AccessioniPrimary (citable) accession number: B9KCS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3