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B9KCS8

- SYL_CAMLR

UniProt

B9KCS8 - SYL_CAMLR

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Campylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei582 – 5821ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCLAR306263:GH7X-1043-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Cla_1045
    OrganismiCampylobacter lari (strain RM2100 / D67 / ATCC BAA-1060)
    Taxonomic identifieri306263 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
    ProteomesiUP000007727: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 809809Leucine--tRNA ligasePRO_1000199186Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi306263.Cla_1045.

    Structurei

    3D structure databases

    ProteinModelPortaliB9KCS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi579 – 5835"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9KCS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYEAGKIEK KWQKIWQEKE YFEPKDDFSL PKKYILSMFP YPSGRIHMGH    50
    VRNYSIGDAM ARYYRKKGFN VLHPIGFDSF GMPAENAAIK HGIHPKKWTY 100
    ENIDYMQNEL ASLGFSFSKK RMLATSDPLY TKFEQEFFIK MYEKGLIYTK 150
    EAEVNWCEND KTVLANEQVE DGKCWRCGHE VIRKKMPGYY VKITAYADEL 200
    LQDLKKLEGK WPSQVLTMQE NWIGKSTGLS FDFDIEENNK ISAKKINVFT 250
    TRAETIYGVS YIALAPDHEI VNELIDKKLL DQDVIAKIQN IQNQTPRQRQ 300
    AAPKEGYFLN LYVIHPLSKE KIPLWVANFV LSDYGSGAVM SVPAHDERDY 350
    EFAKTYNLAI KKVIYKDEND AQCYTLKEGV LTSSGEFDQL ECNDAREKIS 400
    LKIESLGIGK KVTNFKIRDW GVSRQRYWGA PIPMIKCDSC GIVPQKIENL 450
    PITLPEDVVI NGEGNPLDKH ETWKECICPK CGKKAQKESD TLDTFFESSW 500
    YFARFASDDK TWQEKAVDEK SVNYWMNVDE YIGGIEHAIL HLLYARFFQK 550
    ALRDLGYLKD DEPFNRLLTQ GMVTKDGAKM SKSKGNVVDP DYIIEKYGAD 600
    SARLFILFAA PPAKELEWND SALEGAFKFI NRLYEKAMSL ECGKLQEIDH 650
    QSLNKEEKYA RLKVYEALKK SFEVYEESFA FNTLIAACME ALNALNAINH 700
    KEVSKEAFYI ILNILEPIIP HVCFELSEYL FKCENFKVLK IKDEVFIKDS 750
    FNIAISVNGK KRAQIEINSE AKEDEILALA KENVAKWLEG KTIVKEIYID 800
    KKLVNLVVK 809
    Length:809
    Mass (Da):93,357
    Last modified:March 24, 2009 - v1
    Checksum:iAE1DA80F77FDCD12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000932 Genomic DNA. Translation: ACM64367.1.
    RefSeqiYP_002575618.1. NC_012039.1.

    Genome annotation databases

    EnsemblBacteriaiACM64367; ACM64367; Cla_1045.
    GeneIDi7410779.
    KEGGicla:Cla_1045.
    PATRICi20062569. VBICamLar15090_1029.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000932 Genomic DNA. Translation: ACM64367.1 .
    RefSeqi YP_002575618.1. NC_012039.1.

    3D structure databases

    ProteinModelPortali B9KCS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 306263.Cla_1045.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM64367 ; ACM64367 ; Cla_1045 .
    GeneIDi 7410779.
    KEGGi cla:Cla_1045.
    PATRICi 20062569. VBICamLar15090_1029.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CLAR306263:GH7X-1043-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence and analysis of the human pathogen Campylobacter lari."
      Miller W.G., Wang G., Binnewies T.T., Parker C.T.
      Foodborne Pathog. Dis. 5:371-386(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RM2100 / D67 / ATCC BAA-1060.

    Entry informationi

    Entry nameiSYL_CAMLR
    AccessioniPrimary (citable) accession number: B9KCS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3