B9K9S2 (HIS4_THENN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
EC=5.3.1.16

Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene names

Name:	hisA
Ordered Locus Names:	CTN_1529

Organism

Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E) [Complete proteome] [HAMAP]

Taxonomic identifier

309803 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Thermotogae › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › Thermotoga neapolitana

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_01014
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP-Rule MF_01014
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the HisA/HisF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP-Rule MF_01014		PRO_1000148989
Sites
	Active site	8	1	Proton acceptor By similarity
	Active site	127	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9K9S2 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: B041251A345BA9BF	FASTA	248	27,952
	10 20 30 40 50 60 MLVIPAIDLY RKKVVRMVKG KKENTIFYEK DPIELVEKLV EEGFSLIHVV DLSRAIEESD 70 80 90 100 110 120 ENLPVLEKLS SYADHIQIGG GIRILEYAKK LLGMGFRRQI VSSKVLEDPS FLKKLKEIGV 130 140 150 160 170 180 NPVFSLDTRE GKVAFKGWLD EKDIDPVFLV NRLKEFGLEE IVHTEIEKDG TLKEHDFSLT 190 200 210 220 230 240 ERIALETGVK VIAAGGISSE RSLEEALEVH RRTNGLLKGV IVGRAFLEGT LTVEVMKRYA CQENNSVS

References

[1]

"The genome sequence of the hyperthermophilic bacterium Thermotoga neapolitana." Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J., Kim J.J., Park K.J., Lee S.Y. Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49049 / DSM 4359 / NS-E.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000916 Genomic DNA. Translation: ACM23705.1.
RefSeq	YP_002535071.1. NC_011978.1.
3D structure databases
ProteinModelPortal	B9K9S2.
ModBase	Search...
Protein-protein interaction databases
STRING	309803.CTN_1529.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACM23705; ACM23705; CTN_1529.
GeneID	7378157.
KEGG	tna:CTN_1529.
PATRIC	23941883. VBITheNea118396_1520.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0106.
HOGENOM	HOG000224614.
KO	K01814.
ProtClustDB	PRK14114.
Enzyme and pathway databases
UniPathway	UPA00031; UER00009.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_01014. HisA.
InterPro	IPR013785. Aldolase_TIM. IPR006062. His_biosynth. IPR023016. Isoase_HisA. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00977. His_biosynth. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HIS4_THENN

Accession

Primary (citable) accession number: B9K9S2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program