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B9K8S7

- ASSY_THENN

UniProt

B9K8S7 - ASSY_THENN

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Protein
Argininosuccinate synthase
Gene
argG, CTN_1184
Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei85 – 851Citrulline By similarity
Binding sitei115 – 1151ATP; via amide nitrogen By similarity
Binding sitei117 – 1171Aspartate By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei121 – 1211Citrulline By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei178 – 1781Citrulline By similarity
Binding sitei187 – 1871Citrulline By similarity
Binding sitei268 – 2681Citrulline By similarity
Binding sitei280 – 2801Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 169ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTNEA309803:GJFG-1223-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:CTN_1184
OrganismiThermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Taxonomic identifieri309803 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000000445: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Argininosuccinate synthaseUniRule annotation
PRO_1000116294Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi309803.CTN_1184.

Structurei

3D structure databases

ProteinModelPortaliB9K8S7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9K8S7-1 [UniParc]FASTAAdd to Basket

« Hide

MKEKVVLAYS GGLDTSVILK WLCEKGFEVI AYVANVGQKD DFEAIKEKAL    50
KTGASKVYIE DLRREFVTDY IFTALLGNAL YEGRYLLGTA IARPLIAKRQ 100
VEIAEKEGAQ YVAHGATGKG NDQVRFELTY AALNPNLKVI SPWKDPEFLS 150
RFKGRTDLIN YAREKGIPVK VSKKRPYSED ENLMHISHEA GKLEDPMYIP 200
DEDVFTWTVS PKEAPDEETL LEIHFEKGVP VKVVNLKDGT EKTDPLELFE 250
YLNEIGAKNG VGRLDMVENR FIGIKSRGVY ETPGATILWI AHRDLEGITM 300
DKEVMHLRDM LAPKFSELIY NGFWFSPEME FLLAAFKKSQ ENVTGKVIVS 350
VYKGNVMPVA RYSPCSLYNP ELSSMDVEGG FDATDSKGFI NIHALRLKVY 400
RLTKKGYEK 409
Length:409
Mass (Da):46,234
Last modified:March 24, 2009 - v1
Checksum:i3A98E4F518E3B1D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000916 Genomic DNA. Translation: ACM23360.1.
RefSeqiWP_015919675.1. NC_011978.1.
YP_002534726.1. NC_011978.1.

Genome annotation databases

EnsemblBacteriaiACM23360; ACM23360; CTN_1184.
GeneIDi7379075.
KEGGitna:CTN_1184.
PATRICi23941172. VBITheNea118396_1172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000916 Genomic DNA. Translation: ACM23360.1 .
RefSeqi WP_015919675.1. NC_011978.1.
YP_002534726.1. NC_011978.1.

3D structure databases

ProteinModelPortali B9K8S7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309803.CTN_1184.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM23360 ; ACM23360 ; CTN_1184 .
GeneIDi 7379075.
KEGGi tna:CTN_1184.
PATRICi 23941172. VBITheNea118396_1172.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci TNEA309803:GJFG-1223-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the hyperthermophilic bacterium Thermotoga neapolitana."
    Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J., Kim J.J., Park K.J., Lee S.Y.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49049 / DSM 4359 / NS-E.

Entry informationi

Entry nameiASSY_THENN
AccessioniPrimary (citable) accession number: B9K8S7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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