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B9K8S7

- ASSY_THENN

UniProt

B9K8S7 - ASSY_THENN

Protein

Argininosuccinate synthase

Gene

argG

Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei85 – 851CitrullineUniRule annotation
    Binding sitei115 – 1151ATP; via amide nitrogenUniRule annotation
    Binding sitei117 – 1171AspartateUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei121 – 1211CitrullineUniRule annotation
    Binding sitei122 – 1221AspartateUniRule annotation
    Binding sitei125 – 1251CitrullineUniRule annotation
    Binding sitei178 – 1781CitrullineUniRule annotation
    Binding sitei187 – 1871CitrullineUniRule annotation
    Binding sitei268 – 2681CitrullineUniRule annotation
    Binding sitei280 – 2801CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 169ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTNEA309803:GJFG-1223-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:CTN_1184
    OrganismiThermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
    Taxonomic identifieri309803 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000000445: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Argininosuccinate synthasePRO_1000116294Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi309803.CTN_1184.

    Structurei

    3D structure databases

    ProteinModelPortaliB9K8S7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9K8S7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKEKVVLAYS GGLDTSVILK WLCEKGFEVI AYVANVGQKD DFEAIKEKAL    50
    KTGASKVYIE DLRREFVTDY IFTALLGNAL YEGRYLLGTA IARPLIAKRQ 100
    VEIAEKEGAQ YVAHGATGKG NDQVRFELTY AALNPNLKVI SPWKDPEFLS 150
    RFKGRTDLIN YAREKGIPVK VSKKRPYSED ENLMHISHEA GKLEDPMYIP 200
    DEDVFTWTVS PKEAPDEETL LEIHFEKGVP VKVVNLKDGT EKTDPLELFE 250
    YLNEIGAKNG VGRLDMVENR FIGIKSRGVY ETPGATILWI AHRDLEGITM 300
    DKEVMHLRDM LAPKFSELIY NGFWFSPEME FLLAAFKKSQ ENVTGKVIVS 350
    VYKGNVMPVA RYSPCSLYNP ELSSMDVEGG FDATDSKGFI NIHALRLKVY 400
    RLTKKGYEK 409
    Length:409
    Mass (Da):46,234
    Last modified:March 24, 2009 - v1
    Checksum:i3A98E4F518E3B1D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000916 Genomic DNA. Translation: ACM23360.1.
    RefSeqiWP_015919675.1. NC_011978.1.
    YP_002534726.1. NC_011978.1.

    Genome annotation databases

    EnsemblBacteriaiACM23360; ACM23360; CTN_1184.
    GeneIDi7379075.
    KEGGitna:CTN_1184.
    PATRICi23941172. VBITheNea118396_1172.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000916 Genomic DNA. Translation: ACM23360.1 .
    RefSeqi WP_015919675.1. NC_011978.1.
    YP_002534726.1. NC_011978.1.

    3D structure databases

    ProteinModelPortali B9K8S7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 309803.CTN_1184.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM23360 ; ACM23360 ; CTN_1184 .
    GeneIDi 7379075.
    KEGGi tna:CTN_1184.
    PATRICi 23941172. VBITheNea118396_1172.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci TNEA309803:GJFG-1223-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the hyperthermophilic bacterium Thermotoga neapolitana."
      Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J., Kim J.J., Park K.J., Lee S.Y.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49049 / DSM 4359 / NS-E.

    Entry informationi

    Entry nameiASSY_THENN
    AccessioniPrimary (citable) accession number: B9K8S7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3