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Protein

NAD kinase

Gene

nadK

Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51Proton acceptorUniRule annotation1
Binding sitei56NADUniRule annotation1
Binding sitei130NADUniRule annotation1
Binding sitei149NADUniRule annotation1
Binding sitei184NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 52NADUniRule annotation2
Nucleotide bindingi119 – 120NADUniRule annotation2
Nucleotide bindingi160 – 165NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:CTN_0931
OrganismiThermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Taxonomic identifieri309803 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000000445 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001925271 – 258NAD kinaseAdd BLAST258

Proteomic databases

PRIDEiB9K824

Interactioni

Protein-protein interaction databases

STRINGi309803.CTN_0931

Structurei

3D structure databases

SMRiB9K824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

B9K824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAILYREE KEKEGVLLKE KLSREHEVVS FHEASASNVV DADLIVVVGG
60 70 80 90 100
DGTMLRAARK AADGTPLVGF KAGRLGFLTS YTLEEVDQFL EDLRKGNFRE
110 120 130 140 150
ELRWFIRVES DIGSHLALND ATLERDLSGK MVEIEVNVEH HSSMWFFADG
160 170 180 190 200
VVVASPTGST AYSLSIGGPI IFPECEVLEI SPIAPQFFLT RSVVIPSSFK
210 220 230 240 250
VTVECQREIN LLIDGTMVGK TRRVIVQKAE KYVKILRPIK YDYVAVIREK

LGYGRRIE
Length:258
Mass (Da):28,920
Last modified:March 24, 2009 - v1
Checksum:i982B7FB01B9634E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000916 Genomic DNA Translation: ACM23107.1
RefSeqiWP_015919424.1, NC_011978.1

Genome annotation databases

EnsemblBacteriaiACM23107; ACM23107; CTN_0931
KEGGitna:CTN_0931

Similar proteinsi

Entry informationi

Entry nameiNADK_THENN
AccessioniPrimary (citable) accession number: B9K824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health