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Protein

Endonuclease V

Gene

nfi

Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi43MagnesiumUniRule annotation1
Metal bindingi110MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciTNEA309803:G1GAR-795-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
Gene namesi
Name:nfiUniRule annotation
Ordered Locus Names:CTN_0800
OrganismiThermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Taxonomic identifieri309803 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000000445 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001485401 – 225Endonuclease VAdd BLAST225

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei80Interaction with target DNAUniRule annotation1

Protein-protein interaction databases

STRINGi309803.CTN_0800

Structurei

3D structure databases

ProteinModelPortaliB9K7P3
SMRiB9K7P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105Y7X Bacteria
COG1515 LUCA
HOGENOMiHOG000229135
KOiK05982
OMAiCKYRVPE
OrthoDBiPOG091H0CQB

Family and domain databases

CDDicd06559 Endonuclease_V, 1 hit
HAMAPiMF_00801 Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581 Endonuclease-V
PANTHERiPTHR28511 PTHR28511, 1 hit
PfamiView protein in Pfam
PF04493 Endonuclease_5, 1 hit

Sequencei

Sequence statusi: Complete.

B9K7P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYKKLHEWD LSPEEAMKIQ NVLREKILFK PFEGEPKYVA GVDLSFPKRE
60 70 80 90 100
EGLAVIVVME YPTFKIVELV SERGKVDFPY IPGLLAFREG PLFLKAWEKL
110 120 130 140 150
KTKPDVVVFD GQGIAHPRKL GIASHMGLFI EIPTIGVAKS RLYGTYREPE
160 170 180 190 200
NRRCSWSYLY DNEEIIGCVM RTREGSAPIF VSPGHLIDVE SSIRLVKSFT
210 220
LPGRRLPEPT RMAHIYTQRL KKGLF
Length:225
Mass (Da):25,812
Last modified:March 24, 2009 - v1
Checksum:iB5A6DE9F6C163D67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000916 Genomic DNA Translation: ACM22976.1
RefSeqiWP_015919293.1, NC_011978.1

Genome annotation databases

EnsemblBacteriaiACM22976; ACM22976; CTN_0800
KEGGitna:CTN_0800

Similar proteinsi

Entry informationi

Entry nameiNFI_THENN
AccessioniPrimary (citable) accession number: B9K7P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: March 28, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health