Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciTNEA309803:GJFG-780-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:CTN_0753
OrganismiThermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Taxonomic identifieri309803 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000000445 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Probable N-glycosylase/DNA lyasePRO_1000191874Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi309803.CTN_0753.

Structurei

3D structure databases

ProteinModelPortaliB9K7J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
KOiK03653.
OMAiELCFCIL.
OrthoDBiEOG68SW1J.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

B9K7J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELLKELER IREEAKPLVE QRFEEFKRLG EEGTEEDLFC ELSFCVLTAN
60 70 80 90 100
WSAEGGIRAQ KEIGKGFVHL PLEELAEKLR EVGHRYPQKR AEFIVENRKL
110 120 130 140 150
LGKLKNLVKG DPFQSREFLV RNAKGIGWKE ASHFLRNTGV EDLAILDKHV
160 170 180 190 200
LRLMKRHGLI QEIPKGWSKK RYLYVEEILR KVAEAFGESP GKFDLYLWYL

VKGKVDK
Length:207
Mass (Da):24,210
Last modified:March 24, 2009 - v1
Checksum:iDB4F7E3EF71C6204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000916 Genomic DNA. Translation: ACM22929.1.
RefSeqiWP_004082367.1. NC_011978.1.

Genome annotation databases

EnsemblBacteriaiACM22929; ACM22929; CTN_0753.
KEGGitna:CTN_0753.
PATRICi23940271. VBITheNea118396_0736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000916 Genomic DNA. Translation: ACM22929.1.
RefSeqiWP_004082367.1. NC_011978.1.

3D structure databases

ProteinModelPortaliB9K7J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi309803.CTN_0753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM22929; ACM22929; CTN_0753.
KEGGitna:CTN_0753.
PATRICi23940271. VBITheNea118396_0736.

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
KOiK03653.
OMAiELCFCIL.
OrthoDBiEOG68SW1J.

Enzyme and pathway databases

BioCyciTNEA309803:GJFG-780-MONOMER.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the hyperthermophilic bacterium Thermotoga neapolitana."
    Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J., Kim J.J., Park K.J., Lee S.Y.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49049 / DSM 4359 / NS-E.

Entry informationi

Entry nameiOGG1_THENN
AccessioniPrimary (citable) accession number: B9K7J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: July 22, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.