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B9K7J6

- OGG1_THENN

UniProt

B9K7J6 - OGG1_THENN

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Protein

Probable N-glycosylase/DNA lyase

Gene

ogg

Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites).UniRule annotation

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291UniRule annotation

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: UniProtKB-HAMAP
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: UniProtKB-HAMAP

GO - Biological processi

  1. base-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciTNEA309803:GJFG-780-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-glycosylase/DNA lyaseUniRule annotation
Including the following 2 domains:
8-oxoguanine DNA glycosylaseUniRule annotation (EC:3.2.2.-UniRule annotation)
DNA-(apurinic or apyrimidinic site) lyaseUniRule annotation (EC:4.2.99.18UniRule annotation)
Short name:
AP lyaseUniRule annotation
Gene namesi
Name:oggUniRule annotation
Ordered Locus Names:CTN_0753
OrganismiThermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Taxonomic identifieri309803 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000000445: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Probable N-glycosylase/DNA lyasePRO_1000191874Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi309803.CTN_0753.

Structurei

3D structure databases

ProteinModelPortaliB9K7J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type-2 OGG1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1059.
HOGENOMiHOG000224507.
KOiK03653.
OrthoDBiEOG68SW1J.

Family and domain databases

HAMAPiMF_00241. Ogg.
InterProiIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamiPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFiPIRSF005954. Thrmst_ogg. 1 hit.
SMARTiSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMiSSF48150. SSF48150. 1 hit.

Sequencei

Sequence statusi: Complete.

B9K7J6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEELLKELER IREEAKPLVE QRFEEFKRLG EEGTEEDLFC ELSFCVLTAN
60 70 80 90 100
WSAEGGIRAQ KEIGKGFVHL PLEELAEKLR EVGHRYPQKR AEFIVENRKL
110 120 130 140 150
LGKLKNLVKG DPFQSREFLV RNAKGIGWKE ASHFLRNTGV EDLAILDKHV
160 170 180 190 200
LRLMKRHGLI QEIPKGWSKK RYLYVEEILR KVAEAFGESP GKFDLYLWYL

VKGKVDK
Length:207
Mass (Da):24,210
Last modified:March 24, 2009 - v1
Checksum:iDB4F7E3EF71C6204
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000916 Genomic DNA. Translation: ACM22929.1.
RefSeqiYP_002534295.1. NC_011978.1.

Genome annotation databases

EnsemblBacteriaiACM22929; ACM22929; CTN_0753.
GeneIDi7378778.
KEGGitna:CTN_0753.
PATRICi23940271. VBITheNea118396_0736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000916 Genomic DNA. Translation: ACM22929.1 .
RefSeqi YP_002534295.1. NC_011978.1.

3D structure databases

ProteinModelPortali B9K7J6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309803.CTN_0753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM22929 ; ACM22929 ; CTN_0753 .
GeneIDi 7378778.
KEGGi tna:CTN_0753.
PATRICi 23940271. VBITheNea118396_0736.

Phylogenomic databases

eggNOGi COG1059.
HOGENOMi HOG000224507.
KOi K03653.
OrthoDBi EOG68SW1J.

Enzyme and pathway databases

BioCyci TNEA309803:GJFG-780-MONOMER.

Family and domain databases

HAMAPi MF_00241. Ogg.
InterProi IPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view ]
Pfami PF00730. HhH-GPD. 1 hit.
[Graphical view ]
PIRSFi PIRSF005954. Thrmst_ogg. 1 hit.
SMARTi SM00478. ENDO3c. 1 hit.
[Graphical view ]
SUPFAMi SSF48150. SSF48150. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the hyperthermophilic bacterium Thermotoga neapolitana."
    Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J., Kim J.J., Park K.J., Lee S.Y.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49049 / DSM 4359 / NS-E.

Entry informationi

Entry nameiOGG1_THENN
AccessioniPrimary (citable) accession number: B9K7J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 1, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3