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B9K6R4 (GCSPB_THENN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Ordered Locus Names:CTN_0471
OrganismThermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E) [Complete proteome] [HAMAP]
Taxonomic identifier309803 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_1000148001

Amino acid modifications

Modified residue2621N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B9K6R4 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 5CE87EB29B2DD102

FASTA48654,829
        10         20         30         40         50         60 
MTIFDKSKRG RRAFTIPERD VPEYPLSERF SRRTPLKLPE VSEPDVVRHY TELARKNYAV 

        70         80         90        100        110        120 
DVGIYPLGSC TMKYNPKLNE RTANLPGFRN VHPLQPEETL QGCLQLMYEL KAMLCEITGM 

       130        140        150        160        170        180 
DDMTLQPAAG AHGELTGMLI VKKFFDDRKD TKRKKVLVPD SAHGTNPASA SMVGFEVVEI 

       190        200        210        220        230        240 
KSKNGMVDVE DLRKHLDDEV AAVMLTNPNT LGLFERDILK IAELTHNCGA LLYYDGANLN 

       250        260        270        280        290        300 
AIMGKVKPGD MGFDIVHLNL HKTFSTPHGM GGPGSGPVGV KRHLVDFLPF PNVEKEGNLY 

       310        320        330        340        350        360 
RLTVPKKTIG RVRSFFGNFP VLVKAYSYIL MMGRDGLEKV SEMAVLNANY LKKKISRFLK 

       370        380        390        400        410        420 
VPYDGFCMHE FVASAEEVFK KTGVRTLDIA KRILDYGVHP PTVYFPLIVP EALMIEPTET 

       430        440        450        460        470        480 
ESKETLDRYA EILEKVIKEA FENPDVLKNA PHRTPVRRVN EVLASRKPVF RWRGKYEAGD 


RNQQGT 

« Hide

References

[1]"The genome sequence of the hyperthermophilic bacterium Thermotoga neapolitana."
Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J., Kim J.J., Park K.J., Lee S.Y.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49049 / DSM 4359 / NS-E.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000916 Genomic DNA. Translation: ACM22647.1.
RefSeqYP_002534013.1. NC_011978.1.

3D structure databases

ProteinModelPortalB9K6R4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING309803.CTN_0471.

Proteomic databases

PRIDEB9K6R4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM22647; ACM22647; CTN_0471.
GeneID7378335.
KEGGtna:CTN_0471.
PATRIC23939699. VBITheNea118396_0464.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239368.
KOK00283.
OrthoDBEOG6HMXDX.
ProtClustDBPRK04366.

Enzyme and pathway databases

BioCycTNEA309803:GJFG-483-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_THENN
AccessionPrimary (citable) accession number: B9K6R4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families