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B9K6R4

- GCSPB_THENN

UniProt

B9K6R4 - GCSPB_THENN

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTNEA309803:GJFG-483-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:CTN_0471
OrganismiThermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NS-E)
Taxonomic identifieri309803 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000000445: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000148001Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 2621N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiB9K6R4.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi309803.CTN_0471.

Structurei

3D structure databases

ProteinModelPortaliB9K6R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B9K6R4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIFDKSKRG RRAFTIPERD VPEYPLSERF SRRTPLKLPE VSEPDVVRHY
60 70 80 90 100
TELARKNYAV DVGIYPLGSC TMKYNPKLNE RTANLPGFRN VHPLQPEETL
110 120 130 140 150
QGCLQLMYEL KAMLCEITGM DDMTLQPAAG AHGELTGMLI VKKFFDDRKD
160 170 180 190 200
TKRKKVLVPD SAHGTNPASA SMVGFEVVEI KSKNGMVDVE DLRKHLDDEV
210 220 230 240 250
AAVMLTNPNT LGLFERDILK IAELTHNCGA LLYYDGANLN AIMGKVKPGD
260 270 280 290 300
MGFDIVHLNL HKTFSTPHGM GGPGSGPVGV KRHLVDFLPF PNVEKEGNLY
310 320 330 340 350
RLTVPKKTIG RVRSFFGNFP VLVKAYSYIL MMGRDGLEKV SEMAVLNANY
360 370 380 390 400
LKKKISRFLK VPYDGFCMHE FVASAEEVFK KTGVRTLDIA KRILDYGVHP
410 420 430 440 450
PTVYFPLIVP EALMIEPTET ESKETLDRYA EILEKVIKEA FENPDVLKNA
460 470 480
PHRTPVRRVN EVLASRKPVF RWRGKYEAGD RNQQGT
Length:486
Mass (Da):54,829
Last modified:March 24, 2009 - v1
Checksum:i5CE87EB29B2DD102
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000916 Genomic DNA. Translation: ACM22647.1.
RefSeqiWP_015918966.1. NC_011978.1.
YP_002534013.1. NC_011978.1.

Genome annotation databases

EnsemblBacteriaiACM22647; ACM22647; CTN_0471.
GeneIDi7378335.
KEGGitna:CTN_0471.
PATRICi23939699. VBITheNea118396_0464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000916 Genomic DNA. Translation: ACM22647.1 .
RefSeqi WP_015918966.1. NC_011978.1.
YP_002534013.1. NC_011978.1.

3D structure databases

ProteinModelPortali B9K6R4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 309803.CTN_0471.

Proteomic databases

PRIDEi B9K6R4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM22647 ; ACM22647 ; CTN_0471 .
GeneIDi 7378335.
KEGGi tna:CTN_0471.
PATRICi 23939699. VBITheNea118396_0464.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci TNEA309803:GJFG-483-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the hyperthermophilic bacterium Thermotoga neapolitana."
    Lim S.K., Kim J.S., Cha S.H., Park B.C., Lee D.S., Tae H.S., Kim S.-J., Kim J.J., Park K.J., Lee S.Y.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49049 / DSM 4359 / NS-E.

Entry informationi

Entry nameiGCSPB_THENN
AccessioniPrimary (citable) accession number: B9K6R4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3