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B9K115 (LLDD_AGRVS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase [cytochrome]

EC=1.1.2.3
Gene names
Name:lldD
Ordered Locus Names:Avi_5439
OrganismAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4)) [Complete proteome] [HAMAP]
Taxonomic identifier311402 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H+. HAMAP-Rule MF_01559

Cofactor

FMN By similarity. HAMAP-Rule MF_01559

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

Ontologies

Keywords
   LigandFlavoprotein
FMN
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlactate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionFMN binding

Inferred from electronic annotation. Source: InterPro

L-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379L-lactate dehydrogenase [cytochrome] HAMAP-Rule MF_01559
PRO_0000383412

Regions

Domain1 – 379379FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

Sequences

Sequence LengthMass (Da)Tools
B9K115 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: B883A68B231322A2

FASTA37941,207
        10         20         30         40         50         60 
MIISSSTDYR EAARRRLPPF LFHYIDGGAY SEHTMRRNID DLADLALRQR VLKSVGTVDI 

        70         80         90        100        110        120 
STTLFDEELA MPVVLAPVGL TGMYARRGEV QAARAAEKKG IPLTLSTVSV CPIEEVQAAS 

       130        140        150        160        170        180 
NRPIWFQLYV LRDRGFMKNA LERAWAAGIR KLVFTVDMPV PGARYRDAHS GMSGPNASLR 

       190        200        210        220        230        240 
RIIQAVMHPT WAIDVGLLGK PHDLGNVSAY RQQKTNLADY VGWLGENFDP SIGWKDLEWI 

       250        260        270        280        290        300 
RDFWKGPMII KGILDPEDAK DAVRFGADGI IVSNHGGRQL DGVLSSARAL PAIAAAVKGD 

       310        320        330        340        350        360 
LTILADSGIR SGLDVVRMIA QGADGVLIGR AFVYALAAAG QAGVENLLDL FAKEMRVAMT 

       370 
LTGARSIAEI SPDSLVRGL 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000634 Genomic DNA. Translation: ACM38563.1.
RefSeqYP_002547279.1. NC_011988.1.

3D structure databases

ProteinModelPortalB9K115.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING311402.Avi_5439.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM38563; ACM38563; Avi_5439.
GeneID7381535.
KEGGavi:Avi_5439.
PATRIC20823591. VBIAgrVit37146_1499.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1304.
HOGENOMHOG000217464.
KOK00101.
OMAVAKEVNN.
OrthoDBEOG6HMXBG.
ProtClustDBCLSK2475528.

Enzyme and pathway databases

BioCycAVIT311402:GH2Y-3677-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01559. L_lact_dehydr.
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
IPR020920. L-lactate_DHase_cyt.
[Graphical view]
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLLDD_AGRVS
AccessionPrimary (citable) accession number: B9K115
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families