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B9JZN5

- FTHS_AGRVS

UniProt

B9JZN5 - FTHS_AGRVS

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVIT311402:GH2Y-2444-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Avi_3272
OrganismiAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Taxonomic identifieri311402 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium
ProteomesiUP000001596: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_1000185242Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi311402.Avi_3272.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9JZN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDIEIARAA SKLAITQIGE RLGISPGDLQ PYGHDKAKIS ASFLHSLEDR
60 70 80 90 100
KDGKLILVTA INPTPAGEGK TTTTVGLVDG LNRIGAKAMV CVREPSLGPC
110 120 130 140 150
FGVKGGAAGG GRAQVVPMED INLHFTGDFH AITSAHNLLA AMIDNHIYWG
160 170 180 190 200
NEQDLDTRRI AWRRVVDMND RALREMVGAL GGVRNGFPRE TGFDITVASE
210 220 230 240 250
VMAILCLARD LADLEERLGQ IVIGYRRDKT PVHARDIKAH QAMTVLLKEA
260 270 280 290 300
MQPNLVQTLE NNPALVHGGP FANIAHGCNS VVATRAALKL ADYVVTEAGF
310 320 330 340 350
GADLGAEKFF DIKCRKAGLR PAAAVIVATV RALKMNGGVA KTELGHEDVA
360 370 380 390 400
ALVRGAVNLG RHVENVRGFG VPVIVAINHF LSDTPAEIAA LQDYAASIGV
410 420 430 440 450
EAVLCRHWAE GGAGIEELAR KVAAMADSGI ADFQPLYPDD MPLFAKIETV
460 470 480 490 500
AKRIYRAGSV TADRAVIDQL SQFEAMGYGD LPVCIAKTQY SFSTDPSLLG
510 520 530 540 550
APDGHEVHVR DVRLSAGAGF VVAITGDIMT MPGLPRKPAA ETIRLDDDGL

VEGLF
Length:555
Mass (Da):59,093
Last modified:March 24, 2009 - v1
Checksum:iD56E7BD0AA301A7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000633 Genomic DNA. Translation: ACM37345.1.
RefSeqiYP_002550356.1. NC_011989.1.

Genome annotation databases

EnsemblBacteriaiACM37345; ACM37345; Avi_3272.
GeneIDi7387442.
KEGGiavi:Avi_3272.
PATRICi20830388. VBIAgrVit37146_4844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000633 Genomic DNA. Translation: ACM37345.1 .
RefSeqi YP_002550356.1. NC_011989.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 311402.Avi_3272.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM37345 ; ACM37345 ; Avi_3272 .
GeneIDi 7387442.
KEGGi avi:Avi_3272.
PATRICi 20830388. VBIAgrVit37146_4844.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci AVIT311402:GH2Y-2444-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S4 / ATCC BAA-846.

Entry informationi

Entry nameiFTHS_AGRVS
AccessioniPrimary (citable) accession number: B9JZN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: November 26, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3