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B9JZN5

- FTHS_AGRVS

UniProt

B9JZN5 - FTHS_AGRVS

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAVIT311402:GH2Y-2444-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Avi_3272
    OrganismiAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
    Taxonomic identifieri311402 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium
    ProteomesiUP000001596: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_1000185242Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi311402.Avi_3272.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9JZN5-1 [UniParc]FASTAAdd to Basket

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    MSDIEIARAA SKLAITQIGE RLGISPGDLQ PYGHDKAKIS ASFLHSLEDR    50
    KDGKLILVTA INPTPAGEGK TTTTVGLVDG LNRIGAKAMV CVREPSLGPC 100
    FGVKGGAAGG GRAQVVPMED INLHFTGDFH AITSAHNLLA AMIDNHIYWG 150
    NEQDLDTRRI AWRRVVDMND RALREMVGAL GGVRNGFPRE TGFDITVASE 200
    VMAILCLARD LADLEERLGQ IVIGYRRDKT PVHARDIKAH QAMTVLLKEA 250
    MQPNLVQTLE NNPALVHGGP FANIAHGCNS VVATRAALKL ADYVVTEAGF 300
    GADLGAEKFF DIKCRKAGLR PAAAVIVATV RALKMNGGVA KTELGHEDVA 350
    ALVRGAVNLG RHVENVRGFG VPVIVAINHF LSDTPAEIAA LQDYAASIGV 400
    EAVLCRHWAE GGAGIEELAR KVAAMADSGI ADFQPLYPDD MPLFAKIETV 450
    AKRIYRAGSV TADRAVIDQL SQFEAMGYGD LPVCIAKTQY SFSTDPSLLG 500
    APDGHEVHVR DVRLSAGAGF VVAITGDIMT MPGLPRKPAA ETIRLDDDGL 550
    VEGLF 555
    Length:555
    Mass (Da):59,093
    Last modified:March 24, 2009 - v1
    Checksum:iD56E7BD0AA301A7C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000633 Genomic DNA. Translation: ACM37345.1.
    RefSeqiYP_002550356.1. NC_011989.1.

    Genome annotation databases

    EnsemblBacteriaiACM37345; ACM37345; Avi_3272.
    GeneIDi7387442.
    KEGGiavi:Avi_3272.
    PATRICi20830388. VBIAgrVit37146_4844.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000633 Genomic DNA. Translation: ACM37345.1 .
    RefSeqi YP_002550356.1. NC_011989.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 311402.Avi_3272.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM37345 ; ACM37345 ; Avi_3272 .
    GeneIDi 7387442.
    KEGGi avi:Avi_3272.
    PATRICi 20830388. VBIAgrVit37146_4844.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci AVIT311402:GH2Y-2444-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S4 / ATCC BAA-846.

    Entry informationi

    Entry nameiFTHS_AGRVS
    AccessioniPrimary (citable) accession number: B9JZN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3