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B9JZN5 (FTHS_AGRVS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Avi_3272
OrganismAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4)) [Complete proteome] [HAMAP]
Taxonomic identifier311402 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000185242

Regions

Nucleotide binding64 – 718ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B9JZN5 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: D56E7BD0AA301A7C

FASTA55559,093
        10         20         30         40         50         60 
MSDIEIARAA SKLAITQIGE RLGISPGDLQ PYGHDKAKIS ASFLHSLEDR KDGKLILVTA 

        70         80         90        100        110        120 
INPTPAGEGK TTTTVGLVDG LNRIGAKAMV CVREPSLGPC FGVKGGAAGG GRAQVVPMED 

       130        140        150        160        170        180 
INLHFTGDFH AITSAHNLLA AMIDNHIYWG NEQDLDTRRI AWRRVVDMND RALREMVGAL 

       190        200        210        220        230        240 
GGVRNGFPRE TGFDITVASE VMAILCLARD LADLEERLGQ IVIGYRRDKT PVHARDIKAH 

       250        260        270        280        290        300 
QAMTVLLKEA MQPNLVQTLE NNPALVHGGP FANIAHGCNS VVATRAALKL ADYVVTEAGF 

       310        320        330        340        350        360 
GADLGAEKFF DIKCRKAGLR PAAAVIVATV RALKMNGGVA KTELGHEDVA ALVRGAVNLG 

       370        380        390        400        410        420 
RHVENVRGFG VPVIVAINHF LSDTPAEIAA LQDYAASIGV EAVLCRHWAE GGAGIEELAR 

       430        440        450        460        470        480 
KVAAMADSGI ADFQPLYPDD MPLFAKIETV AKRIYRAGSV TADRAVIDQL SQFEAMGYGD 

       490        500        510        520        530        540 
LPVCIAKTQY SFSTDPSLLG APDGHEVHVR DVRLSAGAGF VVAITGDIMT MPGLPRKPAA 

       550 
ETIRLDDDGL VEGLF 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000633 Genomic DNA. Translation: ACM37345.1.
RefSeqYP_002550356.1. NC_011989.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING311402.Avi_3272.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM37345; ACM37345; Avi_3272.
GeneID7387442.
KEGGavi:Avi_3272.
PATRIC20830388. VBIAgrVit37146_4844.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycAVIT311402:GH2Y-2444-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_AGRVS
AccessionPrimary (citable) accession number: B9JZN5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways