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B9JXY6

- MASZ_AGRVS

UniProt

B9JXY6 - MASZ_AGRVS

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Protein

Malate synthase G

Gene

glcB

Organism
Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161Acetyl-CoA; via carbonyl oxygenUniRule annotation
Binding sitei274 – 2741Acetyl-CoAUniRule annotation
Binding sitei311 – 3111Acetyl-CoAUniRule annotation
Active sitei338 – 3381Proton acceptorUniRule annotation
Binding sitei338 – 3381GlyoxylateUniRule annotation
Metal bindingi430 – 4301MagnesiumUniRule annotation
Binding sitei430 – 4301GlyoxylateUniRule annotation
Metal bindingi458 – 4581MagnesiumUniRule annotation
Binding sitei539 – 5391Acetyl-CoA; via carbonyl oxygenUniRule annotation
Active sitei629 – 6291Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciAVIT311402:GH2Y-48-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase GUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Name:glcBUniRule annotation
Ordered Locus Names:Avi_0057
OrganismiAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Taxonomic identifieri311402 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium
ProteomesiUP000001596: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 726726Malate synthase GPRO_1000147423Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei615 – 6151Cysteine sulfenic acid (-SOH)UniRule annotation

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi311402.Avi_0057.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni123 – 1242Acetyl-CoA bindingUniRule annotation
Regioni455 – 4584Glyoxylate bindingUniRule annotation

Sequence similaritiesi

Belongs to the malate synthase family. GlcB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiSQFIENE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

B9JXY6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARVEQFGLA IEQDLYDFLV SEALPGTGVE PEAFFQHFSS LVHELAPKNR
60 70 80 90 100
ALLAKRDAFQ AQLDNWYKQN GAPSDLAAYE AFLRDIGYLL PEGPDFSVTT
110 120 130 140 150
SNVDAEIASI AGPQLVVPVM NARYALNAAN ARWGSLYDAL YGTDAISEAD
160 170 180 190 200
GAEKGRGYNP KRGEKVIAWA RAFLDQSVPL AGGRWADVAG LALTDGYLDV
210 220 230 240 250
TLASGDKTGL MDPSQLAGTF SEDGSVTSYL LRRNGLHVEI CIDAKGAIGA
260 270 280 290 300
ADKANINDIR MESAITAIMD CEDSVAAVDA EDKILAYSNW LGLMKGDLEE
310 320 330 340 350
VVTKGDHVFT RTLNPDLEFT DPQGKPFTVA SRSLMLIRNV GHLMTNPAIL
360 370 380 390 400
DRDGAEVPEG IMDAMVTAVI ALHDIGPNGR RKNSRRGSMY VVKPKMHGPE
410 420 430 440 450
EVAFAVEIFT RVEQALGMEP NTIKMGIMDE ERRTTVNLKE CIRAAKDRVV
460 470 480 490 500
FINTGFLDRT GDEIHTSMEA GPMIRKGDMK QAAWIAAYEN WNVDIGLQCG
510 520 530 540 550
LSGHAQIGKG MWAMPDLMAA MLEQKIAHPK AGANTAWVPS PTAATLHATH
560 570 580 590 600
YHQVDVAGVQ AGLKSRTRAK LSDILSVPVA SRPNWTPEEI QRELDNNAQG
610 620 630 640 650
ILGYVVRWID QGIGCSKVPD INNVGLMEDR ATLRISAQHM ANWLHHGVVT
660 670 680 690 700
EAQVIETLKR MAAIVDQQNA GDSAYRPMAA DFDTSIAFQA ALDLVLKGRE
710 720
QPNGYTEPVL HRRRLELKAT AIPAKV
Length:726
Mass (Da):79,097
Last modified:March 24, 2009 - v1
Checksum:i57D86651BD96E7EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000633 Genomic DNA. Translation: ACM35016.1.
RefSeqiWP_012654546.1. NC_011989.1.
YP_002548020.1. NC_011989.1.

Genome annotation databases

EnsemblBacteriaiACM35016; ACM35016; Avi_0057.
GeneIDi7389052.
KEGGiavi:Avi_0057.
PATRICi20825166. VBIAgrVit37146_2273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000633 Genomic DNA. Translation: ACM35016.1 .
RefSeqi WP_012654546.1. NC_011989.1.
YP_002548020.1. NC_011989.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 311402.Avi_0057.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM35016 ; ACM35016 ; Avi_0057 .
GeneIDi 7389052.
KEGGi avi:Avi_0057.
PATRICi 20825166. VBIAgrVit37146_2273.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi SQFIENE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci AVIT311402:GH2Y-48-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S4 / ATCC BAA-846.

Entry informationi

Entry nameiMASZ_AGRVS
AccessioniPrimary (citable) accession number: B9JXY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3