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B9JWI2 (GCSP_AGRVS) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Avi_2252
OrganismAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4)) [Complete proteome] [HAMAP]
Taxonomic identifier311402 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000147961

Amino acid modifications

Modified residue7041N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B9JWI2 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 956197CAE86B42D8

FASTA954103,381
        10         20         30         40         50         60 
MTTPTEFQFT DYQPYDFANR RHIGPSPAEM DEMLKTVGYD SLDGLIAATV PASIRQSAPL 

        70         80         90        100        110        120 
VWGKAMSERE ALDKLRETAN KNKALTSLIG QGYYGTITPP VIQRNILENP AWYTAYTPYQ 

       130        140        150        160        170        180 
PEISQGRLEA LLNFQTMICD LTGLDVANAS LLDEATAAAE AMAMAERVAK SKAKAFFVDS 

       190        200        210        220        230        240 
NCHPQTIAVI QTRAEPLGWG VVVGNPFTDL NPGEVFGALF QYPGTHGHVS DFTPLINALH 

       250        260        270        280        290        300 
NAQAIAAVAA DPLALLLLKS PGEMGADIAI GSSQRFGVPV GYGGPHAAYM AVKDAIKRSM 

       310        320        330        340        350        360 
PGRLVGVSVD SRGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM YAVFHGPQGL 

       370        380        390        400        410        420 
KAIAQQVHQK TVLLAKGLEK LGFTIEPETF FDTITLEVGH MQGLILRAAV AEGVNLRKVG 

       430        440        450        460        470        480 
TTKIGISLDE RTRPATLEAV WRAFGGNFAV GDFTPDYRLP TSLLRTSQYL THPIFHMNRA 

       490        500        510        520        530        540 
ESEMTRYIRR LSDRDLALDR AMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFAPADQALG 

       550        560        570        580        590        600 
YQEMIDDLSE KLCAVTGYDA ISMQPNSGAQ GEYAGLLTIR NYHLAKGDTH RTVCLIPTSA 

       610        620        630        640        650        660 
HGTNPASAQM AGMLVVPVKA LDNGDVDLAD FRTKAEQHST NLSCCMITYP STHGVFEETV 

       670        680        690        700        710        720 
REICEITHAH GGQVYLDGAN MNAMVGIARP GDIGSDVSHL NLHKTFCIPH GGGGPGMGPI 

       730        740        750        760        770        780 
GVKAHLTPYL PGHVETDGRP GAVSAAPYGS PSILPISWSY CLMMGGEGLT QATKVAILNA 

       790        800        810        820        830        840 
NYIAARLTGA YDVLYTSASG RVAHECIIDT RPLADSAGVT VDDVAKRLID CGFHAPTMSW 

       850        860        870        880        890        900 
PVAGTLMIEP TESETKAELD RFCTAMLAIR EEARAIEDGR MDKTNNPLKN APHTVEDLVG 

       910        920        930        940        950 
EWDRPYSRDQ ACYPPGAFRV DKYWSSVNRV DNVYGDRNLV CTCPPMSEYA EAAE 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000633 Genomic DNA. Translation: ACM36610.1.
RefSeqYP_002549618.1. NC_011989.1.

3D structure databases

ProteinModelPortalB9JWI2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING311402.Avi_2252.

Proteomic databases

PRIDEB9JWI2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM36610; ACM36610; Avi_2252.
GeneID7386347.
KEGGavi:Avi_2252.
PATRIC20828720. VBIAgrVit37146_4020.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycAVIT311402:GH2Y-1688-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_AGRVS
AccessionPrimary (citable) accession number: B9JWI2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families