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B9JWI2

- GCSP_AGRVS

UniProt

B9JWI2 - GCSP_AGRVS

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciAVIT311402:GH2Y-1688-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Avi_2252
    OrganismiAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
    Taxonomic identifieri311402 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium
    ProteomesiUP000001596: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_1000147961Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei704 – 7041N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiB9JWI2.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi311402.Avi_2252.

    Structurei

    3D structure databases

    ProteinModelPortaliB9JWI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9JWI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTPTEFQFT DYQPYDFANR RHIGPSPAEM DEMLKTVGYD SLDGLIAATV    50
    PASIRQSAPL VWGKAMSERE ALDKLRETAN KNKALTSLIG QGYYGTITPP 100
    VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNFQTMICD LTGLDVANAS 150
    LLDEATAAAE AMAMAERVAK SKAKAFFVDS NCHPQTIAVI QTRAEPLGWG 200
    VVVGNPFTDL NPGEVFGALF QYPGTHGHVS DFTPLINALH NAQAIAAVAA 250
    DPLALLLLKS PGEMGADIAI GSSQRFGVPV GYGGPHAAYM AVKDAIKRSM 300
    PGRLVGVSVD SRGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
    YAVFHGPQGL KAIAQQVHQK TVLLAKGLEK LGFTIEPETF FDTITLEVGH 400
    MQGLILRAAV AEGVNLRKVG TTKIGISLDE RTRPATLEAV WRAFGGNFAV 450
    GDFTPDYRLP TSLLRTSQYL THPIFHMNRA ESEMTRYIRR LSDRDLALDR 500
    AMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFAPADQALG YQEMIDDLSE 550
    KLCAVTGYDA ISMQPNSGAQ GEYAGLLTIR NYHLAKGDTH RTVCLIPTSA 600
    HGTNPASAQM AGMLVVPVKA LDNGDVDLAD FRTKAEQHST NLSCCMITYP 650
    STHGVFEETV REICEITHAH GGQVYLDGAN MNAMVGIARP GDIGSDVSHL 700
    NLHKTFCIPH GGGGPGMGPI GVKAHLTPYL PGHVETDGRP GAVSAAPYGS 750
    PSILPISWSY CLMMGGEGLT QATKVAILNA NYIAARLTGA YDVLYTSASG 800
    RVAHECIIDT RPLADSAGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
    TESETKAELD RFCTAMLAIR EEARAIEDGR MDKTNNPLKN APHTVEDLVG 900
    EWDRPYSRDQ ACYPPGAFRV DKYWSSVNRV DNVYGDRNLV CTCPPMSEYA 950
    EAAE 954
    Length:954
    Mass (Da):103,381
    Last modified:March 24, 2009 - v1
    Checksum:i956197CAE86B42D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000633 Genomic DNA. Translation: ACM36610.1.
    RefSeqiWP_015916031.1. NC_011989.1.
    YP_002549618.1. NC_011989.1.

    Genome annotation databases

    EnsemblBacteriaiACM36610; ACM36610; Avi_2252.
    GeneIDi7386347.
    KEGGiavi:Avi_2252.
    PATRICi20828720. VBIAgrVit37146_4020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000633 Genomic DNA. Translation: ACM36610.1 .
    RefSeqi WP_015916031.1. NC_011989.1.
    YP_002549618.1. NC_011989.1.

    3D structure databases

    ProteinModelPortali B9JWI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 311402.Avi_2252.

    Proteomic databases

    PRIDEi B9JWI2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM36610 ; ACM36610 ; Avi_2252 .
    GeneIDi 7386347.
    KEGGi avi:Avi_2252.
    PATRICi 20828720. VBIAgrVit37146_4020.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci AVIT311402:GH2Y-1688-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S4 / ATCC BAA-846.

    Entry informationi

    Entry nameiGCSP_AGRVS
    AccessioniPrimary (citable) accession number: B9JWI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3