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B9JWI2

- GCSP_AGRVS

UniProt

B9JWI2 - GCSP_AGRVS

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, Avi_2252
Organism
Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciAVIT311402:GH2Y-1688-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Avi_2252
OrganismiAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Taxonomic identifieri311402 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium
ProteomesiUP000001596: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_1000147961Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei704 – 7041N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiB9JWI2.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi311402.Avi_2252.

Structurei

3D structure databases

ProteinModelPortaliB9JWI2.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B9JWI2-1 [UniParc]FASTAAdd to Basket

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MTTPTEFQFT DYQPYDFANR RHIGPSPAEM DEMLKTVGYD SLDGLIAATV    50
PASIRQSAPL VWGKAMSERE ALDKLRETAN KNKALTSLIG QGYYGTITPP 100
VIQRNILENP AWYTAYTPYQ PEISQGRLEA LLNFQTMICD LTGLDVANAS 150
LLDEATAAAE AMAMAERVAK SKAKAFFVDS NCHPQTIAVI QTRAEPLGWG 200
VVVGNPFTDL NPGEVFGALF QYPGTHGHVS DFTPLINALH NAQAIAAVAA 250
DPLALLLLKS PGEMGADIAI GSSQRFGVPV GYGGPHAAYM AVKDAIKRSM 300
PGRLVGVSVD SRGNRAYRLS LQTREQHIRR EKATSNICTA QVLLAVMASM 350
YAVFHGPQGL KAIAQQVHQK TVLLAKGLEK LGFTIEPETF FDTITLEVGH 400
MQGLILRAAV AEGVNLRKVG TTKIGISLDE RTRPATLEAV WRAFGGNFAV 450
GDFTPDYRLP TSLLRTSQYL THPIFHMNRA ESEMTRYIRR LSDRDLALDR 500
AMIPLGSCTM KLNATAEMLP ITWPEFSDIH PFAPADQALG YQEMIDDLSE 550
KLCAVTGYDA ISMQPNSGAQ GEYAGLLTIR NYHLAKGDTH RTVCLIPTSA 600
HGTNPASAQM AGMLVVPVKA LDNGDVDLAD FRTKAEQHST NLSCCMITYP 650
STHGVFEETV REICEITHAH GGQVYLDGAN MNAMVGIARP GDIGSDVSHL 700
NLHKTFCIPH GGGGPGMGPI GVKAHLTPYL PGHVETDGRP GAVSAAPYGS 750
PSILPISWSY CLMMGGEGLT QATKVAILNA NYIAARLTGA YDVLYTSASG 800
RVAHECIIDT RPLADSAGVT VDDVAKRLID CGFHAPTMSW PVAGTLMIEP 850
TESETKAELD RFCTAMLAIR EEARAIEDGR MDKTNNPLKN APHTVEDLVG 900
EWDRPYSRDQ ACYPPGAFRV DKYWSSVNRV DNVYGDRNLV CTCPPMSEYA 950
EAAE 954
Length:954
Mass (Da):103,381
Last modified:March 24, 2009 - v1
Checksum:i956197CAE86B42D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000633 Genomic DNA. Translation: ACM36610.1.
RefSeqiWP_015916031.1. NC_011989.1.
YP_002549618.1. NC_011989.1.

Genome annotation databases

EnsemblBacteriaiACM36610; ACM36610; Avi_2252.
GeneIDi7386347.
KEGGiavi:Avi_2252.
PATRICi20828720. VBIAgrVit37146_4020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000633 Genomic DNA. Translation: ACM36610.1 .
RefSeqi WP_015916031.1. NC_011989.1.
YP_002549618.1. NC_011989.1.

3D structure databases

ProteinModelPortali B9JWI2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 311402.Avi_2252.

Proteomic databases

PRIDEi B9JWI2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM36610 ; ACM36610 ; Avi_2252 .
GeneIDi 7386347.
KEGGi avi:Avi_2252.
PATRICi 20828720. VBIAgrVit37146_4020.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci AVIT311402:GH2Y-1688-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S4 / ATCC BAA-846.

Entry informationi

Entry nameiGCSP_AGRVS
AccessioniPrimary (citable) accession number: B9JWI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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