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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei635 – 6351ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVIT311402:GH2Y-3303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Avi_4381
OrganismiAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Taxonomic identifieri311402 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium
ProteomesiUP000001596 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 876876Leucine--tRNA ligasePRO_1000199171Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi311402.Avi_4381.

Structurei

3D structure databases

ProteinModelPortaliB9JV46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi632 – 6365"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiREKNDWE.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9JV46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTERYNPRD AEPRWQEKWS EAKIFETDNN DPREKYYVLE MFPYPSGRIH
60 70 80 90 100
IGHVRNYAMG DVVARYKRAR GYNVLHPMGW DAFGMPAENA AMQNKVHPKD
110 120 130 140 150
WTYQNIASMR AQLKSMGLSL DWSREFATCD VEYYQRQQYL FLDMMEKGLV
160 170 180 190 200
YRKQSKVNWD PVDQTVLANE QVIDGRGWRS GALVEQRELT QWFFKITDFA
210 220 230 240 250
QDLLDALDTL DHWPEKVRLM QKNWIGRSEG LAIRWEIAAG TGPQGFTDVQ
260 270 280 290 300
VYTTRPDTLF GASFLAIAAD HPLAKALSET SSDIAAFCDE CRRAGTSLAA
310 320 330 340 350
LETAEKKGLD TGIKVKHPLD PAWELPVYIA NFVLMDYGTG AIFACPSGDQ
360 370 380 390 400
RDLDFARKYG LPVVPVVMPR DGDAASFTVG DTAYDGDGVM INSRFLDGLT
410 420 430 440 450
TQEAFDVVAG KLTAAQLGNE PVAERRVNFR LRDWGVSRQR YWGCPIPVIH
460 470 480 490 500
CDDCGVVPVP KQDLPVKLPD DVTFDVPGNP LDRHPTWRNV SCPCCGKAAR
510 520 530 540 550
RETDTMDTFV DSSWYYTRFT APWEDKPTDP AVANHWLPVD QYIGGIEHAI
560 570 580 590 600
LHLLYSRFFT RAMRETGHVA VSEPFKGLFT QGMVVHETYR LGSGANGQWV
610 620 630 640 650
APADIRVEDV DGARRAFLLS SGEEVTIGSV EKMSKSKKNV IDPDDILGSY
660 670 680 690 700
GADTARFFVL SDSPPDRDVI WSEAGIEGSH RFVQRLWRLV SEAADVLRTS
710 720 730 740 750
ASTPAKDGAG RAVSQAAHKT LQAVGADLDK LAFNKAVARI YELLNTLAAP
760 770 780 790 800
LTQVASGNAD TSFVAAVRNA TEILIQIIAP MMPHLAEECW AVLGHSGMVS
810 820 830 840 850
QADWPVFHAE LVAENEVVMP VQINGKKKAE LTIGRDADQN AVSQAVLDLD
860 870
AVKAALQGQT PKKIIVVPQR IVNIVV
Length:876
Mass (Da):97,494
Last modified:March 24, 2009 - v1
Checksum:iC5CD367D9EC31F3A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000633 Genomic DNA. Translation: ACM38184.1.
RefSeqiWP_015917594.1. NC_011989.1.
YP_002551196.1. NC_011989.1.

Genome annotation databases

EnsemblBacteriaiACM38184; ACM38184; Avi_4381.
KEGGiavi:Avi_4381.
PATRICi20832232. VBIAgrVit37146_5753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000633 Genomic DNA. Translation: ACM38184.1.
RefSeqiWP_015917594.1. NC_011989.1.
YP_002551196.1. NC_011989.1.

3D structure databases

ProteinModelPortaliB9JV46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi311402.Avi_4381.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM38184; ACM38184; Avi_4381.
KEGGiavi:Avi_4381.
PATRICi20832232. VBIAgrVit37146_5753.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiREKNDWE.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciAVIT311402:GH2Y-3303-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S4 / ATCC BAA-846.

Entry informationi

Entry nameiSYL_AGRVS
AccessioniPrimary (citable) accession number: B9JV46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: April 29, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.