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B9JV46

- SYL_AGRVS

UniProt

B9JV46 - SYL_AGRVS

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Agrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei635 – 6351ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAVIT311402:GH2Y-3303-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Avi_4381
    OrganismiAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4))
    Taxonomic identifieri311402 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium
    ProteomesiUP000001596: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 876876Leucine--tRNA ligasePRO_1000199171Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi311402.Avi_4381.

    Structurei

    3D structure databases

    ProteinModelPortaliB9JV46.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi632 – 6365"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiKGNPLES.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9JV46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTERYNPRD AEPRWQEKWS EAKIFETDNN DPREKYYVLE MFPYPSGRIH    50
    IGHVRNYAMG DVVARYKRAR GYNVLHPMGW DAFGMPAENA AMQNKVHPKD 100
    WTYQNIASMR AQLKSMGLSL DWSREFATCD VEYYQRQQYL FLDMMEKGLV 150
    YRKQSKVNWD PVDQTVLANE QVIDGRGWRS GALVEQRELT QWFFKITDFA 200
    QDLLDALDTL DHWPEKVRLM QKNWIGRSEG LAIRWEIAAG TGPQGFTDVQ 250
    VYTTRPDTLF GASFLAIAAD HPLAKALSET SSDIAAFCDE CRRAGTSLAA 300
    LETAEKKGLD TGIKVKHPLD PAWELPVYIA NFVLMDYGTG AIFACPSGDQ 350
    RDLDFARKYG LPVVPVVMPR DGDAASFTVG DTAYDGDGVM INSRFLDGLT 400
    TQEAFDVVAG KLTAAQLGNE PVAERRVNFR LRDWGVSRQR YWGCPIPVIH 450
    CDDCGVVPVP KQDLPVKLPD DVTFDVPGNP LDRHPTWRNV SCPCCGKAAR 500
    RETDTMDTFV DSSWYYTRFT APWEDKPTDP AVANHWLPVD QYIGGIEHAI 550
    LHLLYSRFFT RAMRETGHVA VSEPFKGLFT QGMVVHETYR LGSGANGQWV 600
    APADIRVEDV DGARRAFLLS SGEEVTIGSV EKMSKSKKNV IDPDDILGSY 650
    GADTARFFVL SDSPPDRDVI WSEAGIEGSH RFVQRLWRLV SEAADVLRTS 700
    ASTPAKDGAG RAVSQAAHKT LQAVGADLDK LAFNKAVARI YELLNTLAAP 750
    LTQVASGNAD TSFVAAVRNA TEILIQIIAP MMPHLAEECW AVLGHSGMVS 800
    QADWPVFHAE LVAENEVVMP VQINGKKKAE LTIGRDADQN AVSQAVLDLD 850
    AVKAALQGQT PKKIIVVPQR IVNIVV 876
    Length:876
    Mass (Da):97,494
    Last modified:March 24, 2009 - v1
    Checksum:iC5CD367D9EC31F3A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000633 Genomic DNA. Translation: ACM38184.1.
    RefSeqiYP_002551196.1. NC_011989.1.

    Genome annotation databases

    EnsemblBacteriaiACM38184; ACM38184; Avi_4381.
    GeneIDi7387955.
    KEGGiavi:Avi_4381.
    PATRICi20832232. VBIAgrVit37146_5753.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000633 Genomic DNA. Translation: ACM38184.1 .
    RefSeqi YP_002551196.1. NC_011989.1.

    3D structure databases

    ProteinModelPortali B9JV46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 311402.Avi_4381.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM38184 ; ACM38184 ; Avi_4381 .
    GeneIDi 7387955.
    KEGGi avi:Avi_4381.
    PATRICi 20832232. VBIAgrVit37146_5753.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi KGNPLES.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci AVIT311402:GH2Y-3303-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S4 / ATCC BAA-846.

    Entry informationi

    Entry nameiSYL_AGRVS
    AccessioniPrimary (citable) accession number: B9JV46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3