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B9JTS9 (MDH_AGRVS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:Avi_4129
OrganismAgrobacterium vitis (strain S4 / ATCC BAA-846) (Rhizobium vitis (strain S4)) [Complete proteome] [HAMAP]
Taxonomic identifier311402 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacterium

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Malate dehydrogenase HAMAP-Rule MF_00487
PRO_1000191637

Regions

Nucleotide binding10 – 156NAD By similarity
Nucleotide binding119 – 1213NAD By similarity

Sites

Active site1761Proton acceptor By similarity
Binding site341NAD By similarity
Binding site831Substrate By similarity
Binding site891Substrate By similarity
Binding site961NAD By similarity
Binding site1211Substrate By similarity
Binding site1521Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B9JTS9 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 96B7E865462D6123

FASTA32033,510
        10         20         30         40         50         60 
MARNKIALIG SGMIGGTLAH LAGLKELGDI VLFDIADGVP QGKGLDIAQS SPVEGFNAKL 

        70         80         90        100        110        120 
TGSSDYAAIE GADVCIVTAG VPRKPGMSRD DLLGINLKVM EQVGAGIKKY APNAFVICIT 

       130        140        150        160        170        180 
NPLDAMVWAL QKFSGLPANK VVGMAGVLDS SRFRLFLAEE FNVSVQDVTA FVLGGHGDTM 

       190        200        210        220        230        240 
VPLARYSTVG GIPLTDLVKM GWVTAERLEE IIQRTRDGGA EIVGLLKTGS AFYAPAASAI 

       250        260        270        280        290        300 
EMAESYLKDK KRVLPCAAHL TGQYGVKDMY VGVPTVIGAG GVERVIEIEL NKDEEAAFQK 

       310        320 
SVGAVAGLCE ACINIAPALK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000633 Genomic DNA. Translation: ACM37987.1.
RefSeqYP_002550999.1. NC_011989.1.

3D structure databases

ProteinModelPortalB9JTS9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING311402.Avi_4129.

Proteomic databases

ProMEXB9JTS9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM37987; ACM37987; Avi_4129.
GeneID7388918.
KEGGavi:Avi_4129.
PATRIC20831806. VBIAgrVit37146_5542.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAYGQNDIC.
OrthoDBEOG6091FG.

Enzyme and pathway databases

BioCycAVIT311402:GH2Y-3104-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_AGRVS
AccessionPrimary (citable) accession number: B9JTS9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families