B9JML7 (ACDH_AGRRK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]

Gene names

Ordered Locus Names:

Arad_7256

Organism

Agrobacterium radiobacter (strain K84 / ATCC BAA-868) [Complete proteome] [HAMAP]

Taxonomic identifier

311403 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Agrobacterium

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Acetaldehyde dehydrogenase HAMAP MF_01657		PRO_0000387615
Regions
	Nucleotide binding	15 – 18	4	NAD By similarity
	Nucleotide binding	164 – 172	9	NAD By similarity
Sites
	Binding site	289	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9JML7 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 8653544638EF526A	FASTA	313	33,460
	10 20 30 40 50 60 MERTMTPIKA AIIGSGNIGT DLMIKILRTG SGIEMGALVG VDPASDGLER ARRLGVFTTH 70 80 90 100 110 120 EGLDGLRRSP IYKDIGIVFD ATSAKAHERH AEQLRQDGKR AIDLTPAAVG PYIVPVVNLE 130 140 150 160 170 180 ENLNAVNVNM VTCGGQATIP IVAAVARVAP VPYAEIVASI ASRSAGPGTR ANIDEFTETT 190 200 210 220 230 240 ARAIEVVGGA RRGKAIIVLN PAEPPLIMRD TVYCLALTQD QDAVRRSIHD MIDRVRGYVP 250 260 270 280 290 300 GYRLKQEVQF EPLRDARAVG GEEDGPALKV SVFLEVEGAG HYLPSYAGNL DIMTSAALAV 310 AERFARTLIE ENA

References

[1]

"Genome sequences of three Agrobacterium biovars help elucidate the evolution of multichromosome genomes in bacteria." Slater S.C., Goldman B.S., Goodner B., Setubal J.C., Farrand S.K., Nester E.W., Burr T.J., Banta L., Dickerman A.W., Paulsen I., Otten L., Suen G., Welch R., Almeida N.F., Arnold F., Burton O.T., Du Z., Ewing A. , Godsy E., Heisel S., Houmiel K.L., Jhaveri J., Lu J., Miller N.M., Norton S., Chen Q., Phoolcharoen W., Ohlin V., Ondrusek D., Pride N., Stricklin S.L., Sun J., Wheeler C., Wilson L., Zhu H., Wood D.W. J. Bacteriol. 191:2501-2511(2009) [PubMed: 19251847] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K84 / ATCC BAA-868.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000629 Genomic DNA. Translation: ACM28798.1.
RefSeq	YP_002540393.1. NC_011983.1.
3D structure databases
ProteinModelPortal	B9JML7.
ModBase	Search...
Protein-protein interaction databases
STRING	B9JML7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7367247.
GenomeReviews	Gene locus Arad_7256 in contig CP000629_GR.
KEGG	ara:Arad_7256.
PATRIC	20796174. VBIAgrRad129173_0214.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HVKNDAF.
ProtClustDB	PRK08300.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K04073.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH_AGRRK

Accession

Primary (citable) accession number: B9JML7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 3, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program