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B9JML7

- ACDH_AGRRK

UniProt

B9JML7 - ACDH_AGRRK

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Protein

Acetaldehyde dehydrogenase

Gene

Arad_7256

Organism
Agrobacterium radiobacter (strain K84 / ATCC BAA-868)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331Acyl-thioester intermediateUniRule annotation
Binding sitei289 – 2891NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 184NADUniRule annotation
Nucleotide bindingi164 – 1729NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARAD311403:GHU8-4062-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:Arad_7256
OrganismiAgrobacterium radiobacter (strain K84 / ATCC BAA-868)
Taxonomic identifieri311403 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupAgrobacteriumAgrobacterium tumefaciens complex
ProteomesiUP000001600: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Acetaldehyde dehydrogenasePRO_0000387615Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi311403.Arad_7256.

Structurei

3D structure databases

ProteinModelPortaliB9JML7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiYNDENSA.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B9JML7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERTMTPIKA AIIGSGNIGT DLMIKILRTG SGIEMGALVG VDPASDGLER
60 70 80 90 100
ARRLGVFTTH EGLDGLRRSP IYKDIGIVFD ATSAKAHERH AEQLRQDGKR
110 120 130 140 150
AIDLTPAAVG PYIVPVVNLE ENLNAVNVNM VTCGGQATIP IVAAVARVAP
160 170 180 190 200
VPYAEIVASI ASRSAGPGTR ANIDEFTETT ARAIEVVGGA RRGKAIIVLN
210 220 230 240 250
PAEPPLIMRD TVYCLALTQD QDAVRRSIHD MIDRVRGYVP GYRLKQEVQF
260 270 280 290 300
EPLRDARAVG GEEDGPALKV SVFLEVEGAG HYLPSYAGNL DIMTSAALAV
310
AERFARTLIE ENA
Length:313
Mass (Da):33,460
Last modified:March 24, 2009 - v1
Checksum:i8653544638EF526A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000629 Genomic DNA. Translation: ACM28798.1.
RefSeqiYP_002540393.1. NC_011983.1.

Genome annotation databases

EnsemblBacteriaiACM28798; ACM28798; Arad_7256.
GeneIDi7367247.
KEGGiara:Arad_7256.
PATRICi20796174. VBIAgrRad129173_0214.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000629 Genomic DNA. Translation: ACM28798.1 .
RefSeqi YP_002540393.1. NC_011983.1.

3D structure databases

ProteinModelPortali B9JML7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 311403.Arad_7256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM28798 ; ACM28798 ; Arad_7256 .
GeneIDi 7367247.
KEGGi ara:Arad_7256.
PATRICi 20796174. VBIAgrRad129173_0214.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi YNDENSA.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci ARAD311403:GHU8-4062-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K84 / ATCC BAA-868.

Entry informationi

Entry nameiACDH_AGRRK
AccessioniPrimary (citable) accession number: B9JML7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 24, 2009
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3